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Chemical Name: L-Glutathione (Reduced)
Synonyms: GSH, γ-L-Glutamyl-L-cysteinylglycine
CAS Number: 70-18-8
Molecular Formula: C10H17N3O6S
Molecular Weight: 307.32 g/mol
Product Code: Commonly referenced as Glutathione Reduced Powder or similar nomenclature
Recommended Use: Used in pharmaceuticals, nutraceuticals, laboratory research, personal care formula development, and food processing
Supplier: Company information should specify location, emergency phone, and technical contact. Emergency numbers often include CHEMTREC or local equivalents for chemical safety guidance
Relevant Identified Uses: Ingredient in antioxidant formulations, laboratory analytical work, or as a raw material in various industrial applications
Classification: Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008
Label Elements: No symbol or signal word required
Hazard Statement: Not considered hazardous under standard regulatory frameworks
Precautionary Statement: Practice good hygiene and use recommended protective measures to minimize exposure, especially as dust may irritate eyes, nose or throat in sensitive individuals
Physical Hazards: Can form dust that may irritate the respiratory system; otherwise not flammable, explosive, or reactive under normal conditions
Health Hazards: May provoke minor irritation to the skin, eyes or respiratory tract for some individuals
Environmental Hazards: Low risk to the environment in small quantities, due to rapid biodegradability
Component: L-Glutathione (Reduced)
Concentration: Typically 98% or higher
Chemical Family: Tripeptide, Sulfhydryl compound
Impurities: Trace levels of water, hydrolyzed amino acids, or manufacturing residues
Additives: Usually absent; product is often supplied as a pure crystalline or powdered form
EC Number: 200-725-4
General Advice: Move affected person away from source of exposure. Follow good industrial hygiene practice
Inhalation: Remove individual to fresh air. Keep at rest, seek medical advice if symptoms persist or if exposure was significant
Skin Contact: Wash immediately with water and mild soap. Remove contaminated clothing and consult medical help in case of persistent irritation
Eye Contact: Flush with water for at least 15 minutes, opening eyelids to ensure thorough rinsing, and seek medical attention if irritation continues
Ingestion: Rinse mouth. Drink water to dilute. Seek medical advice if feeling unwell; support vital functions if needed
Key Symptoms: Irritation, redness, coughing or shortness of breath if inhaled as dust, mild nausea or gastric upset if accidentally swallowed
Suitable Extinguishing Media: Carbon dioxide, dry chemical, foam, or water spray
Special Hazards Arising from the Substance: Decomposition could produce sulfur oxides or other irritating gases at elevated temperatures
Advice for Firefighters: Wear self-contained breathing apparatus and full protective gear. Avoid inhaling decomposition products
Additional Precautions: Remove containers from fire area if it can be done safely, prevent water runoff from entering drains or waterways as a precaution
Personal Precautions: Use respiratory protection to avoid breathing in dust. Wear gloves, eye protection and suitable laboratory attire
Environmental Precautions: Prevent further leakage or spillage; avoid allowing product to enter drains, sewers, or waterways
Methods for Clean-Up: Sweep up or vacuum with equipment fitted with HEPA filtration, minimize dust creation. Dispose of collected material according to waste regulations
Reference to Other Sections: See “Exposure Controls and Personal Protection” for relevant safety equipment, and “Disposal Considerations” for waste handling guidance
Safe Handling Advice: Handle in a well-ventilated area to prevent inhalation of dust. Avoid contact with eyes, skin, and clothing
Hygiene Practices: Wash hands after handling, before eating, drinking, or using the restroom
Conditions for Safe Storage: Store in tightly closed containers placed in a cool, dry, well-ventilated place
Incompatibilities: Avoid exposure to strong oxidizers, heat sources, or direct sunlight, as these may degrade the product
Packaging Materials: Use materials that protect against moisture and contamination, such as sealed plastic or glass containers with desiccants if necessary
Occupational Exposure Limits: No established thresholds for L-Glutathione (Reduced); general dust limits apply
Engineering Controls: Work in areas with adequate ventilation, such as a laboratory fume hood, and use local exhaust to collect dust
Respiratory Protection: Use a NIOSH- or EN-approved dust mask or respirator if dust forms in significant concentrations
Skin Protection: Wear suitable chemical-resistant gloves (nitrile, neoprene, or similar)
Eye Protection: Use safety goggles or face shield to prevent eye contact
General Protective Measures: Wear lab coat or apron; remove and wash contaminated clothing before reuse
Appearance: White to off-white crystalline powder
Odor: Slight, characteristic or nearly odorless
Odor Threshold: Not established
pH (1% Solution): 3.0–6.0
Melting Point: 192–195°C (decomposition)
Boiling Point: Not applicable (decomposes prior to boiling)
Solubility: Soluble in water; very low solubility in most organic solvents
Vapor Pressure: Not applicable
Vapor Density: Not applicable
Relative Density: Approximately 1.35-1.40 g/cm³
Partition Coefficient (Log Kow): Not determined
Flash Point: Not flammable
Evaporation Rate: Not applicable
Autoignition Temperature: Not self-igniting
Decomposition Temperature: Above 192°C
Viscosity: Not applicable (solid material)
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: No hazardous reactivity under normal conditions
Hazardous Reactions: None known when used as directed
Conditions to Avoid: Heat, light, moisture, incompatible substances (such as strong oxidizers)
Incompatible Materials: Powerful oxidizing agents, acids, bases may cause degradation
Hazardous Decomposition Products: Thermal decomposition may release sulfur oxides, nitrogen oxides, or carbon oxides
Acute Toxicity: Low toxicity in animal studies; oral LD50 in rats estimated to exceed 5,000 mg/kg
Skin Corrosion / Irritation: Not expected to cause skin irritation in most users
Serious Eye Damage / Irritation: Direct contact may cause minor irritation
Respiratory or Skin Sensitization: Not classified as a sensitizer based on available research
Chronic Toxicity: No evidence for long-term health risks in normal use
Carcinogenicity / Mutagenicity / Reproductive Toxicity: No evidence found for carcinogenic, mutagenic or reproductive risks with L-Glutathione (Reduced)
Symptoms of Exposure: Inhalation of dust may cause transient coughing or mild respiratory irritation; ingestion or skin exposure causes little to no symptoms in healthy individuals
Eco-Toxicity: No evidence of toxicity to aquatic organisms at typical concentrations
Persistence and Degradability: Readily biodegradable, breaks down naturally in the environment
Bioaccumulative Potential: Unlikely to bioaccumulate due to rapid metabolism
Mobility in Soil: High solubility in water increases mobility, though product breaks down on contact with microbes
Other Adverse Effects: Minimal risk to the environment from small accidental discharges, as breakdown products are amino acids and peptides found naturally in biology
Disposal Methods: Dispose of in accordance with local, regional, national and international regulations
Waste Treatment Recommendations: Dilute solutions can be flushed to the sewer system with large amounts of water, after confirming compliance with local environmental guidance; solid residues should go to a chemical waste facility
Contaminated Packaging: Rinse and recycle or dispose following approved procedures
Environmental Precautions: Avoid uncontrolled releases; limit product entry into soil, waterways, or storm drains
UN Number: Not regulated
Proper Shipping Name: Not classified as a dangerous good under IMO, IATA, DOT, ADR
Transport Hazard Class: None
Packing Group: Not applicable
Special Precautions: Protect containers from damage and moisture during transport
Environmental Hazards: No special concerns for transportation safety
Regulatory Status: Not classified as hazardous under GHS, REACH, OSHA, WHMIS, or equivalent international frameworks
Inventory Listings: Registered or exempt in major chemical inventories (TSCA, EINECS, DSL)
Label Requirements: No hazard labeling needed, though safety data should accompany shipment
Restrictions: No specific use or handling restrictions identified in available legislation
SARA Title III (Sections 311/312): Not subject
California Proposition 65: Not listed as a chemical known to cause cancer or reproductive risk
Other Standards: Meets purity and safety standards set by food or pharmaceutical ingredient regulations in various regions as appropriate for the intended use
