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L-Aspartic Acid β-Hydroxamate holds a special place in the long tale of amino acid derivatives. Chemists started working with aspartic acid back in the late 1800s. Once folks realized its central role in biochemistry, everyone wanted to see what could be done by tweaking its structure. Through trial and error, researchers began attaching new groups to the aspartic acid backbone, searching for ways to nudge its chemistry into uncharted territory. The β-hydroxamate variant popped up out of necessity, bridging efforts in both medical biochemistry and industrial synthesis. This molecule stands as an example of how incremental curiosity and reproducible research drive chemistry’s steady progress.
L-Aspartic Acid β-Hydroxamate offers a distinctive edge in the world of amino acid derivatives, thanks to its unique hydroxamate moiety. This compound draws attention among both lab workers and industry researchers for its versatility. Having the base structure of aspartic acid means it still shares some basic nutritional and metabolic lines with other amino acids. Adding a β-hydroxamate group moves the compound out of ordinary metabolism, making it more of a research tool and specialty reagent than standard fare.
No point in dancing around it: properties matter to anyone working with chemistry at the bench. L-Aspartic Acid β-Hydroxamate tends to appear as a white to off-white powder, with a slightly acidic tinge to its taste. Solubility plays a big role here — it dissolves comfortably in water, which helps during preparation and analysis in most biological systems. Melting point usually falls below 200°C, so thermal decomposition can become a concern during any heat-intensive processing. This compound’s stability under normal storage conditions suits routine use; still, moisture and light exposure can slowly degrade it, so most people stash it in well-sealed containers away from direct sunlight and humidity. Chemically, the molecule brings both the amine and carboxylic acid groups from aspartic acid, plus a hydroxamate side chain that sparks unique interactions with metal ions and enzymes.
Specs matter, both for safety and performance. Reputable suppliers anchor their listings to purity levels, often measured by HPLC or similar analytic techniques, with purity above 98% being standard in most research settings. Clear labeling spells out not just the IUPAC name, but alternatives like L-aspartic acid β-hydroxamic acid or (S)-2-aminosuccinic acid β-hydroxamate, cutting down on confusion. Labels must provide details about storage instructions, batch numbers, and expiry dates to support full traceability in both academic and industrial contexts. It’s not just a matter of pretty packaging—without clarity at this level, even the best scientists risk irreproducible results or waste.
Synthesizing L-Aspartic Acid β-Hydroxamate pulls from textbook peptide chemistry, but requires thoughtful planning. Chemists often react L-aspartic acid or its esters with hydroxylamine under acidic or basic conditions to attach the β-hydroxamate group. The process calls for precise pH adjustment and temperature control to prevent unwanted side reactions. Purification usually follows, depending on the initial method, via crystallization, filtration, or chromatography to chase away by-products. What happens on paper rarely matches the mess of a real bench: scales block up, pH drifts, and not every batch comes out clean. Documentation of every step — including failed runs — remains crucial, as reproducibility is the only way progress survives beyond a single lab team or publication.
Chemists love seeing how far a new molecule can stretch. The β-hydroxamate group interacts strongly with transition metal ions, serving as a ligand in coordination chemistry and a tool for probing metalloenzymes. Under mild conditions, it can undergo further acylation or cyclization, opening routes to specialty peptides or modified heterocycles. L-Aspartic Acid β-Hydroxamate readily participates in condensation reactions. In many labs, researchers experiment with esterification or amidation, searching for analogues with new solubility profiles or bioactivity. Tethering fluorescent tags or isotopic markers through the hydroxamate site pushes the compound into the world of chemical biology. These sorts of modifications turn a simple derivative into a Swiss army knife for bench science.
That old saying about names and roses fits here. Knowledge of synonyms matters, since a missed ID in the literature search leads to missed opportunities. This molecule pops up under several monikers: L-aspartic acid β-hydroxamate, L-aspartic acid beta-hydroxamic acid, and occasionally as (S)-2-aminosuccinic acid β-hydroxamate. In some older research papers, the abbreviation L-Asp-β-OHAm floats around. Anyone sifting through chemical databases quickly learns that a synonym overlooked is a paper unread, a patent missed, and a connection lost. Naming conventions sometimes vary by supplier, adding a further layer of confusion for those buying across borders or working in multiple languages.
L-Aspartic Acid β-Hydroxamate carries a moderate safety profile, rooted partly in its divergence from natural amino acid metabolism. Routine precautions like gloves, lab coats, and proper ventilation do the trick for daily use in most labs. Inhalation or skin contact should be avoided, as you would with any synthetic organic compound, since long-term effects haven’t always been rigorously studied. Spills clean up with standard absorbents, and disposal in line with local chemical safety guidelines prevents environmental buildup. Training remains key — even experienced hands get complacent, and mistakes pile up fastest when routine breeds indifference. Material safety data sheets aren’t just a bureaucratic checkbox; real accidents have started from skipping steps or mislabeling waste containers.
This compound’s reach stretches far beyond classic biochemistry. In my own stint handling peptide synthesis, the β-hydroxamate group came into play as a building block for enzyme inhibitors and sophisticated metal ion chelators. Medical researchers use it to construct tailored molecules for cancer therapy studies, chasing compounds that selectively block abnormal cell pathways. Its chelating capacity attracts industrial chemists looking to trap heavy metals or tweak reaction selectivity. Ecologists and biochemists see L-Aspartic Acid β-Hydroxamate as a tool for tracking nutrient cycles or probing microbial enzyme activity. As research trends evolve, the compound’s role keeps broadening, finding new applications in diagnostics, enzyme assay development, and functional material synthesis.
L-Aspartic Acid β-Hydroxamate exemplifies bench innovation meeting real-world need. Labs worldwide investigate its potential as an enzyme inhibitor, given the unique way it fits into active sites and stalls critical reactions. Research groups working on neurodegeneration look for protective agents that mimic or block certain metabolic intermediates, and this molecule pops up in their candidate lists. Collaborations between industry and academia look for ways this derivative can improve specialty polymers or surface treatments. Graduate students and postdocs experiment with its chemistry, trying to create new analogues tailored for imaging, drug targeting, or biosensor work. Funding agencies value its flexibility, as the same fundamental structure can blend into a dozen different project proposals, each with technical merit and social impact.
No modern conversation about a specialty chemical can ignore toxicity. Researchers have run animal and cell culture studies to gauge acute and chronic exposure effects. Most toxicity data point toward mild irritation if mishandled, but gaps still exist, especially with long-term or high-dose exposure. Individual metabolism, genetics, and even gut microbiome differences influence how this molecule behaves in a living system. No one should treat the toxicity profile as fixed — every new application brings fresh risk profiles that should trigger fresh investigation. Regulatory authorities review most available data as part of chemical registration, but the onus stays on manufacturers and scientists to push for more comprehensive safety reviews, especially as novel applications expand into environmental or medical spaces.
I’ve seen too many specialty compounds fade from relevance after a few headline papers. L-Aspartic Acid β-Hydroxamate seems poised to buck the trend due to its unusual chemical handle and ongoing demand from biomedical researchers. The field of targeted therapeutics, especially drugs that home in on stubborn enzyme targets, keeps circling back to unusual derivatives like this one. Industrial chemists look for new chelators that break down more readily and leave less environmental impact. Advances in organic synthesis, automated peptide assembly, and high-throughput screening promise new derivatives and analogues that put L-Aspartic Acid β-Hydroxamate right at the center of tomorrow’s innovations. Any progress depends on honest communication between researchers, careful supply chain management, and a willingness to revisit safety and environmental concerns at every step.
L-Aspartic Acid β-Hydroxamate may sound like something out of a college chemistry test, but this compound has carved out a spot for itself in science and medicine. It’s not one of those common names people run into every day, yet its impact reaches into some important corners of research and treatment.
Ask folks involved with enzyme research and you’ll hear L-Aspartic Acid β-Hydroxamate brought up as a potent inhibitor of certain enzymes called amidases and aspartyl proteases. Scientists use it to block asparaginase activity, which can play a role in cell metabolism. By getting in the way of asparaginase, researchers learn more about how cells process amino acids, and how breaking this cycle might slow certain cancers’ growth. Take acute lymphoblastic leukemia, for example. Doctors press for compounds that can suppress the food supply of cancer cells without causing too much harm to healthy ones. This is no small feat—the research dollars invested here show that the payoff matters to real people facing tough diagnoses.
It’s often a long road from the lab bench to a doctor’s office. Early-stage cancer trials explore many options, and only a few move forward. L-Aspartic Acid β-Hydroxamate sometimes steps in as an experimental control, meaning it helps prove how new drug candidates work. Nobody expects it to cure diseases directly, but its value in teasing out what works and what doesn’t is real. In my own brush with research—grinding out long nights in a university lab, tracking cell growth—I saw how control agents like this one sharpen findings. Without them, results blur, and people start chasing false hopes.
New treatments often spark a flood of ethical debates around safety and access. Many inhibitors stall in development because early studies surface concerns about toxicity, or because they can’t target cancerous cells cleanly enough. L-Aspartic Acid β-Hydroxamate, like so many experimental compounds, raises questions scientists must address: How much is too much? Who gets access to promising, but risky, new approaches? Lower-income patients and those in small communities sometimes watch breakthroughs pass them by. As someone whose own relatives struggled to get timely treatment, the gaps in the system feel far from abstract. Decisions made in clinical testing ripple outward to families sitting in waiting rooms everywhere.
Unlocking the potential of compounds like L-Aspartic Acid β-Hydroxamate depends on real teamwork. Research hospitals, pharmaceutical companies, and regulatory agencies win more ground working together. Open data sharing, patient advocacy, and government funding can all help move discoveries toward lives outside the lab. Ordinary people play a role too; volunteering for studies or pushing for fair drug access matters as much as anything happening in a test tube.
There’s no shortcut to the next big medical breakthrough. Compounds like L-Aspartic Acid β-Hydroxamate might never make headlines or splash across fundraising posters. Still, they often serve as stepping stones—generating information, shaping the next trial, fueling the hope that tough problems can one day have answers. Those small advances add up, one test at a time, to help real people lead longer, healthier lives.
L-Aspartic Acid β-Hydroxamate brings together two significant pieces—a natural amino acid backbone and a key functional twist. L-Aspartic acid itself looks simple: a four-carbon chain with two carboxyl groups (COOH), an amino group (NH2) on the α-carbon, and a hydrogen, all arranged in a specific three-dimensional way. This setup isn’t just textbook chemistry; it plays out in real protein chains, hooks into enzymes, and impacts countless metabolic pathways.
Building a hydroxamate from L-Aspartic acid means swapping the carboxylic acid at the β-position. Instead of the regular –COOH group on the side chain, chemists swap in a β-hydroxamate group, which looks like –CONHOH. This small shift punches above its weight because hydroxamate groups do more than just sit there. They grab onto metals—iron, in particular—with a tight embrace. Many bacteria and fungi use natural hydroxamates as part of their search for iron in tough environments. Pharmaceutical chemists borrow this trait, adding hydroxamates to molecules to block certain enzymes or sneak drugs past the body’s natural defenses.
Picture the backbone as four carbon atoms in a line. On the α-carbon sits the amino group (NH2), classic of every amino acid. The carboxyl group closer to the center (the α-carboxyl group) stays the same. The magic happens at the β-carbon, where the carboxyl side chain turns into a β-hydroxamate: –CH2–CONHOH. The shape isn’t just two-dimensional; the L-configuration means it fits perfectly with biological systems designed for the left-handed form of amino acids. This detail matters. Just a flip to the D- configuration changes how enzymes and proteins respond.
As someone who has spent time in a biochemistry lab, swapping a carboxyl for a hydroxamate has always ended up being more than theory. The switch changes how the molecule can chelate, or grab, metal ions. L-Aspartic Acid β-Hydroxamate isn’t just a skeleton for lab chemistry. It steps up as a starting point for anti-cancer research, protecting cells from damage by scavenging metals or blocking harmful enzymes. These changes also pop up in new antibiotics, where that metal-binding power disrupts bacteria’s iron scavenging.
Several studies point to the use of L-Aspartic Acid β-Hydroxamate derivatives for targeting metalloproteases, the enzymes that break down proteins and play a role in spreading cancer. The National Center for Biotechnology Information outlines how these molecules use the bidentate nature of the hydroxamate group to tightly bind the metal atom right in the heart of an enzyme’s active site. That’s how the molecule throws a wrench in the works, stalling the enzyme and dialing back the disease process.
Designing these molecules has challenges. Adding a hydroxamate group ramps up metal chelation but can also trigger off-target effects. Researchers need to keep an eye on specificity, so the molecule locks onto the right target without grabbing every available metal ion in the body. Structurally tweaking the side chains or shielding the molecule with protective groups are two main strategies. This way, chemists fine-tune binding power and lessen unwanted side effects.
The story of L-Aspartic Acid β-Hydroxamate offers a clear example of the impact a single swap can make in medicinal chemistry. The moment scientists dig into how these groups interact—at an atomic level—they stand a much better chance of designing safer, targeted medicines. A molecule that starts with a common backbone, tweaked in just the right spot, becomes more than a laboratory curiosity. It moves closer to use in hospitals and clinics, shaping real outcomes for patients.
L-Aspartic Acid β-Hydroxamate isn’t a new molecule for researchers and lab techs who spend plenty of time around chemical storage facilities. Each compound has quirks, tolerances, and vulnerabilities. From my own benchwork days, the golden rule stuck with me: respect the material, know its limits, and storage mishaps rarely happen. Missing that step once can set off bigger headaches than most want to handle, especially with specialty compounds involved in biological and pharmaceutical research.
This compound doesn’t handle moisture well. Water, even from humid air, encourages breakdown, sometimes leaving you with degraded material instead of a precise research tool. Noticing caked powders or off-colored samples before, I had to ditch samples that sat near slightly-open containers—costly waste from simple errors. L-Aspartic Acid β-Hydroxamate isn’t special for wanting dry conditions, but its purity and effectiveness drop fast if the powder absorbs moisture. Drying agents like silica gel packs help, but they only work if containers actually close tight. Glass bottles with screw caps work way better than flimsy plastic vials, especially for longer storage.
Temperature control ranks just as important. For most specialized amino acid derivatives, room temperature storage stays risky for any duration beyond a week or two. Science supports this: heat gives molecules extra energy, making them react or degrade faster. On one project, I slipped and let stock solution sit next to a heating vent. Not only did I lose the batch, but traces of breakdown products ended up interfering with the next set of tests. L-Aspartic Acid β-Hydroxamate shows the same sensitivity—colder storage conditions keep it shelf-stable. Most chemical suppliers recommend a range between 2°C and 8°C, or a standard refrigerator. Not every lab fridge runs consistently cool, so I check with an independent thermometer to be sure. Freezing rarely benefits this chemical since ice can fracture containers or cause condensation, inviting more trouble when thawing.
Forgetting about light can seem harmless, but plenty of researchers—including me—find faded, discolored compounds after storage in clear bottles under direct lab lights. Ultraviolet radiation breaks chemical bonds. Old samples pulled from well-lit shelves often smell strange or clump up, hinting at slow oxidation. Amber glass provides decent protection, but drawer or box storage adds another layer of care, especially for anything meant to last months.
L-Aspartic Acid β-Hydroxamate deserves careful labeling. Date every bottle, jot down when you open it, and keep notes about any changes in color or texture. It helps track down storage failures and avoid using ineffective material in experiments that demand precision. Labs with digital inventory systems manage this well, but even a simple logbook works. Helping train new lab staff on this point made all the difference—not only did it cut down on waste, it helped junior scientists spot problems early and save time retracing their steps.
Storage isn’t afterthought or busywork—it’s part of the research. Care with L-Aspartic Acid β-Hydroxamate starts with dryness, cool and stable temperature, light shielding, and clear tracking. Skipping steps isn’t just breaking best practices, it risks results and safety. Whether running a large lab or handling a single sample, the little efforts prove themselves over and over. Protect the compound, and it’ll deliver as promised when the experiment begins.
L-Aspartic Acid β-Hydroxamate has started to grab attention in many biochemical labs. Researchers often use it as a chelator or an inhibitor in enzymatic studies. With increasing use, concerns about its safety have surfaced. Comprehending if it brings risks requires more than glancing at the material safety data sheet. You want honest insight, built on not just published facts but also experience from benches, fume hoods, and chemical storerooms.
Finding comprehensive safety records on L-Aspartic Acid β-Hydroxamate isn’t straightforward. It does not have widespread industrial use, so extensive toxicological data simply do not exist. Looking at chemicals with similar structures, researchers find some clues. Hydroxamate-based compounds sometimes bind to metals in unexpected ways and can interfere with certain enzymes in cells. Lab workers have learned the hard way — never ignore subtle details in a molecule’s structure.
What’s known so far: It hasn’t been flagged for carcinogenicity, mutagenicity, or reproductive toxicity in the literature. Acute exposure in small quantities does not appear to harm rodent cells in basic assays. Realistically, this doesn’t mean L-Aspartic Acid β-Hydroxamate won’t cause skin irritation, allergic reactions, or long-term health effects. There's a habit among scientists — if a chemical’s data sheet still looks thin, treat it with the respect you’d give something far more hazardous.
Once, researchers relied on sense of smell or sight to gauge chemical threats — silly, dangerous habits in modern labs. Even mild compounds can build up risks after years of handling, especially if lab culture gets sloppy. Eating, drinking, or keeping open mugs near the bench happens more than researchers want to admit. A workspace with proper air flow makes a huge difference. Gloves, lab coats, goggles — none feel comfortable, but skipping them invites trouble. In labs I’ve worked, complacency causes more exposure than any freak accident.
Safer lab protocols start with careful labeling and proper chemical storage. L-Aspartic Acid β-Hydroxamate may seem like a low-toxicity research tool, but storage alongside acids or oxidizers gets risky. Chemical engineering students, early-career researchers, and seasoned lab techs all benefit from retraining — just reading the newest SDS isn't enough. Experienced researchers know that updating risk assessments can prevent the “it’s always been fine” mindset from leading to harm.
Dealing with spills or accidental exposure, most protocols follow the usual: ventilate, contain, and clean up while using gloves and eye protection. If this compound enters the eye or skin, immediate flushing with copious water works best. Accidental ingestion or major inhalation needs medical consultation, no matter how harmless it looks in a test tube.
Any lab chemical, especially one with incomplete toxicology, should spark conversations among team members about open reporting and thoughtful question-asking. It's not weakness to double-check protocols or push for more frequent hazard assessments. People sometimes forget: no discovery is worth risking their health. Keeping L-Aspartic Acid β-Hydroxamate on lab shelves encourages both curiosity and responsibility. Those who lead by example inspire safer, more diligent habits in everyone working nearby.
L-Aspartic Acid β-Hydroxamate doesn't show up in everyday news, but it holds an important place in the toolkit of researchers who want to understand how cells read their genetic code and process amino acids. After spending time helping out in a biomedical research lab, I've seen how work in this corner of chemistry can eventually shape much larger discoveries. Even a subtle tweak to an amino acid like aspartic acid can tell a powerful story inside a Petri dish or a test tube.
Scientists who look at enzyme action or amino acid metabolism reach for molecules like L-Aspartic Acid β-Hydroxamate. This compound acts as a close cousin to naturally occurring aspartic acid but carries a hydroxamate group that stands out to enzymes. Because it looks close enough to natural targets, it slips into active sites. Instead of reacting in the usual way, it halts the process. Researchers use this trait to block enzymes such as asparaginase or aspartase and observe what happens next. By interfering with enzyme function, the whole pathway can be picked apart, step by step.
Take the fight against certain cancers, for example. Cells depend on specific enzymes to survive and divide. Scientists try to block some of these enzymes to weaken cancer cells or make them more sensitive to treatments. Reading studies about acute lymphoblastic leukemia left a deep impression on me. Researchers found that tweaking amino acid pathways could slow cancer growth. Compounds like L-Aspartic Acid β-Hydroxamate gave them the precision tools they needed to measure, test, and refine these strategies.
Diagnostic tests also lean on such compounds during development. I learned this first-hand watching biochemistry teams fine-tune ways to track enzyme action in patient samples. L-Aspartic Acid β-Hydroxamate works as a controlled blocker, so differences in reaction rates become much clearer. These insights can steer the design of blood tests for inherited metabolic conditions or help in monitoring therapy progress.
Modern research craves more than a snapshot; it’s the moving picture of metabolism that tells the story. By introducing L-Aspartic Acid β-Hydroxamate, scientists can highlight bottlenecks or backup routes in metabolic networks. Mapping these alternate pathways sometimes uncovers fresh options for drug targets, especially for rare disorders where standard routes offer few answers.
Any scientist working with new or modified amino acids keeps safety right up there with curiosity. In the lab, gloves and careful labeling matter as much as the science. Training emphasizes that even if a compound like L-Aspartic Acid β-Hydroxamate isn't widespread in household products, assumptions have no place here. Respect for chemical handling means research progresses without distraction from avoidable mistakes.
As labs keep pushing the boundaries of what’s possible in medicine, agriculture, and testing, the demand for clever research molecules only grows. L-Aspartic Acid β-Hydroxamate stands as a tool that lets scientists pause or slow a pathway, so new questions rise and answers follow. For anyone watching breakthroughs in biochemistry or targeted therapies, the next wave of insights may trace back to work done with supporting players like this unique compound.
| Names | |
| Preferred IUPAC name | (2S)-2-aminosuccinamide |
| Other names |
L-Aspartic acid beta-hydroxamate L-Aspartate beta-hydroxamate L-asparagine hydroxamate Aspartic acid, L-, beta-hydroxamate |
| Pronunciation | /ɛl æˈspɑːrtɪk ˈæsɪd ˌbiː haɪˈdrɒksəˌmeɪt/ |
| Identifiers | |
| CAS Number | 3715-70-4 |
| Beilstein Reference | 83665 |
| ChEBI | CHEBI:28260 |
| ChEMBL | CHEMBL1230493 |
| ChemSpider | 21542788 |
| DrugBank | DB08344 |
| ECHA InfoCard | 13-93103513 |
| EC Number | 1.4.3.16 |
| Gmelin Reference | 85587 |
| KEGG | C05544 |
| MeSH | D000077246 |
| PubChem CID | 137334 |
| RTECS number | CY9306000 |
| UNII | 425H6B2QZ9 |
| UN number | 2811 |
| CompTox Dashboard (EPA) | DTXSID5022236 |
| Properties | |
| Chemical formula | C4H8N2O4 |
| Molar mass | 148.13 g/mol |
| Appearance | White powder |
| Odor | Odorless |
| Density | 1.676 g/cm³ |
| Solubility in water | Soluble in water |
| log P | -2.0 |
| Vapor pressure | Negligible |
| Acidity (pKa) | pKa 3.85 |
| Basicity (pKb) | 8.34 |
| Magnetic susceptibility (χ) | -5.55×10⁻⁶ cm³/mol |
| Dipole moment | 5.1034 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 248.6 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -789.95 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -1265 kJ mol⁻¹ |
| Hazards | |
| Main hazards | Harmful if swallowed. Causes serious eye irritation. Causes skin irritation. |
| GHS labelling | GHS07, GHS08 |
| Pictograms | GHS07 |
| Signal word | Warning |
| Hazard statements | H302: Harmful if swallowed. |
| Precautionary statements | Precautionary statements: P261, P264, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362+P364, P501 |
| NFPA 704 (fire diamond) | 1-1-0 |
| Lethal dose or concentration | LD50 Intraperitoneal Rat: 2800 mg/kg |
| LD50 (median dose) | LD50 (median dose): Oral-rat LD50 > 5000 mg/kg |
| NIOSH | Not Listed |
| PEL (Permissible) | Not established |
| REL (Recommended) | 10 mg/kg |
| Related compounds | |
| Related compounds |
L-Glutamic Acid γ-Hydroxamate L-Asparagine L-Aspartic Acid L-Aspartic Acid β-Methyl Ester N-Methyl-L-aspartic acid |
