© 2026 Nanjing Finechem Holdings Co., Ltd,
All Right Reserved
Product Name: Kolliphor P 188
Chemical Nature: Polyoxyethylene-polyoxypropylene block copolymer
Main Use: Non-ionic surfactant used in pharmaceuticals, personal care, and laboratory settings
Synonyms: Poloxamer 188, Pluronic F68
Appearance: White to off-white powder or solid
Odor: Faint characteristic smell or odorless
Classification: Not classified as hazardous by most regulatory agencies
Primary Risks: Low acute toxicity, mild irritation possible on skin or eyes
Potential Effects: People with sensitive skin may notice redness or mild itching
Inhalation Risk: Practically no risk due to low volatility
Combustion Products: Exposure to smoke or fumes during a fire can irritate the respiratory tract
Chronic Exposure: No clear evidence of long-term health risk for healthy adults
Handling Precautions: General good hygiene and protective equipment recommended
Chemical Composition: Polyethylene oxide and polypropylene oxide block copolymer
Purity: Typically greater than 98% by weight
Common Additives: No routine additives; check batch-specific data
Impurities: Trace levels of unreacted monomers and residual solvents possible
Inhalation: Remove to fresh air, support breathing if exposure to large amounts of dust
Skin Contact: Wash with water and soap if irritation develops
Eye Contact: Rinse with water for several minutes, seek medical attention if discomfort persists
Ingestion: Rinse mouth with water, no major toxicity expected but consult medical professional for large amounts
Medical Advice: Observe for symptoms; symptomatic treatment is usually enough
Suitable Extinguishing Agents: Use water spray, foam, dry chemical, or CO2
Special Hazards: Combustion releases carbon monoxide, carbon dioxide, and possibly low levels of other organic substances
Protective Equipment: Firefighters should wear self-contained breathing apparatus
Fire Behavior: Not highly flammable, but dust can cause explosive mixtures with air
Cool Containers: Spray containers with water if exposed to heat for long periods
Personal Protection: Gloves, protective goggles, and dust mask reduce exposure
Environmental Precaution: Avoid flushing large quantities into watercourses
Cleanup Methods: Sweep up spill; avoid generating dust
Disposal: Collect in appropriate containers for disposal in accordance with local laws
Safe Handling: Work in well-ventilated areas, minimize dust formation
Storage Conditions: Store in tightly closed containers at room temperature
Incompatibles: Strong oxidizers can degrade the substance
Bulk Storage: Keep away from sources of ignition, moisture, and direct sunlight
Personal Hygiene: Wash hands after use, do not eat or drink in work area
Engineering Controls: Local ventilation improves air quality
Respiratory Protection: Dust mask if airborne levels rise
Skin Protection: Gloves reduce the chance of irritation
Eye Protection: Safety glasses prevent dust from contacting eyes
Hygiene Measures: Wash thoroughly after handling, especially before meals
Form: Solid at room temperature
Solubility: Freely soluble in water
pH: Neutral to slightly alkaline (pH 6–8 for a 5% solution)
Melting Point: 52–57°C
Flash Point: Above 180°C, so direct ignition is unlikely under normal usage
Boiling Point: Decomposes before boiling
Vapor Pressure: Negligible at room conditions
Odor: Faint or none
Color: White to off-white
Partition Coefficient (n-octanol/water): Not easily determined, but product shows high water affinity
Chemical Stability: Stable under recommended storage conditions
Decomposition: Begins to break down at temperatures well above typical room conditions
Hazardous Reactions: No strong reactivity under normal conditions, but reacts strongly with oxidizers
Conditions to Avoid: Direct sources of intense heat, strong acids, strong bases, strong oxidizing agents
Acute Toxicity: Oral toxicity is low; large doses may cause mild gastrointestinal upset
Skin Contact: Mild irritation possible after direct, prolonged contact
Eye Contact: Can cause temporary discomfort and redness
Inhalation: Low inhalation risk due to dust particle size and low volatility
Sensitization: Allergic reactions rare but possible in hypersensitive individuals
Chronic Effects: No evidence of carcinogenic, mutagenic, or reproductive toxicity
Aquatic Toxicity: Low toxicity to fish and aquatic organisms
Persistence: Product slowly biodegrades, especially at high concentrations
Mobility: Water soluble, so it can disperse easily in aquatic environments
Bioaccumulation: Expected to have low potential for bioaccumulation
Soil Effects: Little data available, but unlikely to cause toxicity in normal release scenarios
Disposal Methods: Incineration or landfill according to local environmental regulations
Container Disposal: Completely empty packaging can often be recycled or disposed with regular waste
Unwanted Product: Should not be released uncontained to drains or waterways
Recycling Options: Limited, but industrial-scale solvent recovery may be feasible for large volumes
UN Number: Not regulated as a hazardous material for transport
Transport Hazard Class: Not assigned
Packing Group: Not assigned; general packaging guidelines apply
Label Requirements: Standard labeling for non-hazardous industrial goods
Compatibility: Avoid shipping with strong acids or oxidizers
Workplace Regulation: No workplace exposure limits established for the main ingredient
International Transport: Product meets general safety and environmental standards for routine transport
Environmental Regulation: Dispose of in line with local environmental agency requirements
Labeling: No hazard pictogram or warning required under GHS for most uses
Pharmaceutical and Food Standards: Often accepted in prescribed concentrations for specific formulations, but always check up-to-date national regulations
