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Product Name: KAPA TAQ DNA Polymerase
Manufacturer: Kapa Biosystems, part of Roche Diagnostics
Product Code: Specific catalog numbers provided on product label
Recommended Use: DNA amplification in laboratory settings
Contact Information: Customer support details provided by Roche Diagnostics, with dedicated hotline and email
Emergency Telephone: 24-hour emergency response number, provided by Roche or referenced poison control center
Address: Roche Diagnostics global office locations as noted on shipment
Synonyms: Recombinant Taq polymerase enzyme solution
GHS Classification: Not classified as hazardous under GHS for standard laboratory quantities
Signal Word: None required
Hazard Statements: Not expected to cause significant hazardous effects in normal conditions
Pictograms: No pictogram required for non-hazard formulations
Precautionary Statements: Avoid prolonged contact with eyes and skin, standard laboratory hygiene recommended
Potential Health Effects: May cause mild eye or skin irritation for sensitive individuals, ingestion unlikely during proper laboratory use
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Target Organs: Skin, eyes
Main Components: Recombinant Taq DNA polymerase (from Thermus aquaticus, recombinant expression), stabilizing buffer (composed of Tris-HCl, potassium chloride, with trace glycerol, detergent and potentially DTT)
Concentration Range: Enzyme concentration varies by formulation, typically less than 1% by volume, buffer components up to 99%
CAS Numbers: Not assigned specifically to enzyme, buffer materials include standard biochemistry grade chemicals such as Tris (CAS 77-86-1), KCl (CAS 7447-40-7), glycerol (CAS 56-81-5), and water (CAS 7732-18-5)
Impurities: Negligible under standard manufacturing standards, no known hazardous byproducts
Inhalation: Move to fresh air, monitor for irritation or discomfort, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash area thoroughly with soap and water, seek medical advice if irritation develops
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, ensure eyelids are held open, consult ophthalmology if redness or pain continues
Ingestion: Rinse mouth thoroughly, do not induce vomiting, contact medical professional for further guidance
Notes to Physician: Treat symptomatically, no special antidotes necessary for acute exposure to standard reagent
Suitable Extinguishing Media: Use water spray, CO2, dry chemical, or foam based on surrounding materials
Specific Hazards: Decomposition products under fire may yield oxides of carbon, nitrogen and sulfur, avoid inhalation of smoke
Protective Equipment: Firefighters use self-contained breathing apparatus and full protective gear
Explosion Data: Product not considered a fire or explosion hazard, though packaging materials may contribute to fire load
Additional Information: Cool containers exposed to heat with water spray, prevent runoff from firefighting entering drains or water courses
Personal Precautions: Use protective gloves, lab coat, and eye protection to limit contact
Environmental Precautions: Prevent large releases from reaching drains, surface waters or soil
Methods for Cleanup: Absorb spills with inert material, transfer to chemical waste container, clean area with water and soap
Reference to Other Sections: Follow disposal and handling protocols for biological reagents, consult local regulations
Decontamination: Use laboratory grade disinfectants if required, ventilate area if necessary
Safe Handling: Wear standard laboratory PPE (personal protective equipment), use in well-ventilated area, avoid exposure to open skin and mucous membranes
Storage Conditions: Store at -20°C unless otherwise specified, keep container tightly closed, avoid temperature fluctuations
Incompatibilities: Avoid contact with strong acids or bases, oxidizing agents may degrade stabilizing buffer
Transfer Procedures: Use dedicated pipettes and equipment, avoid contamination by other biologicals
Special Requirements: Store upright in original packaging, avoid repeated freeze-thaw cycles
Engineering Controls: Use chemical fume hood if performing procedures producing aerosols or vapors
Personal Protection Equipment: Wear laboratory coat, gloves made from nitrile or latex, and safety glasses
Hygiene Measures: Wash hands thoroughly after handling, avoid eating or drinking around reagents
Occupational Exposure Limits: No established limits for this enzyme or typical buffer components, follow institutional good laboratory practice
Additional Protective Measures: Proper training for laboratory workers minimizes risk
Appearance: Clear, colorless to slightly yellow solution
Odor: Odorless
pH: Typically pH 7-8, depending on buffer composition
Boiling Point: Approximates that of water (100°C at 1 atm)
Melting/Freezing Point: Buffer freezes around 0°C, store below -20°C for stability
Relative Density: Similar to water, slightly higher due to glycerol content
Solubility: Fully miscible in water
Viscosity: May be slightly more viscous than water if high glycerol present
Flash Point: Not applicable
Decomposition Temperature: Not specifically determined, avoid excessive heating
Chemical Stability: Stable if kept cold, avoid extended periods at room temperature
Hazardous Reactions: No dangerous reactions under recommended conditions
Incompatible Materials: Strong oxidizers, acids and alkalis can degrade enzyme
Hazardous Decomposition Products: May include carbon oxides, nitrogen oxides if burnt
Conditions to Avoid: Heat, direct sunlight, repeated freeze-thaw cycles
Acute Toxicity: No acute toxicity expected for laboratory-grade enzyme at used concentrations
Skin Corrosion/Irritation: Mild irritation may occur in sensitive individuals
Serious Eye Damage/Irritation: May cause mild temporary irritation
Respiratory Sensitization: Unlikely under normal laboratory practices
Carcinogenicity: No component listed as carcinogen by IARC, ACGIH, NTP, or OSHA
Mutagenicity: Enzyme does not interact with DNA unless in deliberate PCR reaction, no expected mutagenic effects
Chronic Toxicity: No known chronic effects with proper use
Medical Conditions Aggravated by Exposure: Limited to pre-existing allergies to protein-based reagents
Aquatic Toxicity: No data indicates significant hazard at laboratory concentrations, enzymatic activity unlikely to persist outside controlled environment
Persistence and Degradability: Biodegradable under standard conditions, enzymatic proteins break down quickly
Bioaccumulative Potential: Not expected to bioaccumulate, rapidly metabolized by environmental microbes
Mobility in Soil: Water soluble, not expected to persist in soil
Other Adverse Effects: Avoid unnecessary release into waterways as general good practice
Waste Disposal: Dispose of in accordance with institutional procedures for biological or chemical reagents
Container Disposal: Decontaminate and dispose of empty containers per laboratory safety guidelines
Special Instructions: Consult local, state and federal environmental regulations for disposal of laboratory reagents
Unused Product: Small amounts can often be inactivated by autoclaving prior to disposal
UN Number: Not regulated as dangerous good
Proper Shipping Name: Non-hazardous, laboratory reagent
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: None expected
Special Transport Precautions: Keep cold with coolant packs or dry ice, maintain packaging integrity, avoid rough handling
Labeling Requirements: Follow local labelling obligations, include precautionary statements where required
US Regulations: Not listed under SARA Title III Sections 302, 313, not a CERCLA hazardous substance
EU Classification: Not classified as hazardous under REACH for research use
Inventory Status: All components appear in chemical inventories required for laboratory use
Other Regulations: Observe safety practices outlined by OSHA, WHMIS, and other relevant regulatory frameworks for lab safety
