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Product Name: KAPA SYBR FAST Universal qPCR Master Mix
Product Code: KK4600, KK4620, KK4610, KK4650
Manufacturer: Roche Sequencing Solutions, Inc.
Address: 1301 E. Collins Blvd., Suite 100, Richardson, TX 75081, USA
Telephone: +1 (800) 262-4911
Recommended Use: Laboratory reagent for quantitative PCR applications
Emergency Contact Number: +1 (800) 424-9300 (CHEMTREC)
Prepared By: Roche Diagnostics environmental health and safety team
Classification: Not considered hazardous under OSHA 29 CFR 1910.1200
Hazard Statements: Not classified as hazardous, though may cause mild skin or eye irritation
Pictograms: None
Precautionary Statements: Avoid contact with eyes and skin, do not ingest, ensure adequate ventilation
Other Hazards: Product contains proprietary enzyme blends and buffers; components not expected to pose toxicological or environmental hazards if handled according to standard good laboratory practice
Label Elements: Product labeling includes laboratory use only statement; not for diagnostic procedures
SYBR Green I: <0.1%, proprietary dye
dNTPs (deoxynucleotide triphosphates): <1%, CAS No. 67-48-1 (Tris HCl component)
DNA Polymerase (recombinant): <1%, not classified
MgCl2: <1%, CAS No. 7791-18-6
Buffer components and stabilizers: Proprietary
Water: >95%, CAS No. 7732-18-5
Hazardous Ingredients: None present at or above the OSHA defined reportable thresholds
Inhalation: Move to fresh air if breathing becomes difficult; seek medical attention for persistent symptoms
Skin Contact: Wash thoroughly with soap and water
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing
Ingestion: Rinse mouth, do not induce vomiting; seek medical supervision for any adverse effects
Most Important Symptoms and Effects: May cause minor irritation, no delayed or long-term effects expected
Notes for Physicians: Treat symptomatically, show this sheet to medical personnel if necessary
Suitable Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide
Unsuitable Extinguishing Media: Not determined
Specific Hazards: Product does not support combustion, no flammable ingredients
Hazardous Combustion Products: May release oxides of carbon and nitrogen if combusted
Special Protective Equipment for Fire Fighters: Use standard full protective gear and self-contained breathing apparatus
Advice for Firefighters: Prevent run-off from entering drains and waterways, contain spillage according to protocols for biological reagents
Personal Precautions: Wear laboratory gloves, goggles, and protective lab coat
Environmental Precautions: Prevent spilled material from entering drains or watercourses
Methods for Cleaning Up: Absorb spilled liquid with inert material such as paper towels, wipe surfaces with suitable disinfectant, dispose as laboratory waste
Reference to Other Sections: See Sections 8 and 13 for disposal and personal protection
Precautions for Safe Handling: Use in accordance with good laboratory practices, avoid ingestion and direct contact with skin or eyes
Handling Recommendations: Use pipetting aids, never mouth pipette, avoid splashing, minimize aerosol generation
Conditions for Safe Storage: Store at -20°C until ready for use, avoid repeated freeze-thaw cycles, keep container tightly closed
Storage Class: Biological reagents, non-hazardous
Incompatible Materials: Avoid strong acids or bases that could hydrolyze product components
Specific End Uses: As a reagent in PCR; not for food, drug, or household use
Exposure Limits: No occupational exposure limits established for product components
Engineering Controls: Use in a chemical fume hood or well-ventilated space
Protective Equipment: Wear disposable gloves (nitrile or latex), eye protection (goggles), and a laboratory coat
Respiratory Protection: Not required under normal handling; use a mask for handling large volumes
Hygiene Measures: Wash hands after handling, do not eat/drink in laboratory areas, dispose of contaminated personal protective equipment following laboratory protocols
Appearance: Clear to slightly green-tinged liquid
Odor: Odorless
Odor Threshold: Not applicable
pH: 8.3 ± 0.2 at 25°C
Melting Point/Freezing Point: Not determined, product stable at -20°C
Boiling Point/Range: Approximately 100°C (water-based)
Flash Point: Not applicable (non-flammable aqueous solution)
Evaporation Rate: Comparable to water
Flammability: Does not ignite under normal conditions
Vapor Pressure: Not determined
Density: Approximately 1 g/cm3
Solubility: Fully soluble in water
Partition Coefficient n-octanol/water: Not determined
Auto-ignition Temperature: Not applicable
Decomposition Temperature: Product designed for use at elevated PCR temperatures (up to 95°C), decomposes at higher
Chemical Stability: Stable under recommended storage conditions
Reactivity: No dangerous reactions known under conditions of normal use
Possibility of Hazardous Reactions: None under recommended use
Conditions to Avoid: Excessive heat, repeated freeze-thaw cycles, contamination with strong oxidizers or reducers
Incompatible Materials: Strong acids, bases, and oxidizing agents
Hazardous Decomposition Products: None during intended use; combustion may produce oxides of carbon/nitrogen
Acute Toxicity: Not toxic in laboratory exposures; no dangerous ingredients identified
Skin Corrosion/Irritation: May cause mild irritation following prolonged contact
Serious Eye Damage/Irritation: Mild, transient irritation possible
Respiratory Sensitization: Not expected to sensitize
Skin Sensitization: Not expected based on ingredient data
Germ Cell Mutagenicity: No evidence in the composition
Carcinogenicity: None of the ingredients considered carcinogenic by IARC, NTP, OSHA, or ACGIH
Reproductive Toxicity: Not expected
STOT – single and repeated exposure: No effects reported
Aspiration Hazard: Not an aspiration hazard
Ecotoxicity: Not expected to be hazardous to aquatic life at concentrations encountered in laboratory use
Persistence/Degradability: Major components are biodegradable; SYBR Green I dye persists but used at extremely low concentrations
Bioaccumulative Potential: No bioaccumulative potential expected for this preparation
Mobility in Soil: Moves with water, not significantly adsorbed
Other Adverse Effects: No large-scale environmental impact foreseen in responsible laboratory disposal
Environmental Precautions: Do not dispose of into drains, watercourses, or uncontrolled environments
Product Waste: Dispose as laboratory chemical waste according to local, state, and federal regulations
Contaminated Packaging: Empty containers can be triple-rinsed, defaced, and recycled or disposed as laboratory waste
Disposal Methods: Incineration or landfill at licensed facility, avoid discharge into the environment
Special Considerations: Follow institutional biosafety protocols for qPCR reagent disposal, especially for any potential DNA contaminants
UN Number: Not regulated
Proper Shipping Name: Not dangerous goods
Transport Hazard Class: Not classified
Packing Group: None
Environmental Hazards: Not environmentally hazardous
Special Precautions: Ship on dry ice, avoid physical shock, follow carrier cold chain requirements
Transport Labels: None required for laboratory reagents not containing hazardous substances
OSHA: Not regulated as hazardous
TSCA Inventory: All components are either listed or exempt
SARA Title III (Sections 311/312, 313): Not subject to reporting requirements
CERCLA: Not hazardous
California Prop 65: Product does not contain chemicals listed
WHMIS (Canada): Non-controlled product
Other Regulations: Product labeled for research use only; not intended for use in diagnostic or therapeutic settings
Country-Specific Requirements: Laboratories should consult local regulations and safety protocols regarding handling, storage, and disposal
