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Product Name: HP PCR Template Preparation Kit
Manufacturer: HP Life Science Solutions
Product Number: TPPK-010
Recommended Use: Laboratory reagent for DNA sample preparation
Supplier Contact: HP Life Science Solutions, Customer Service, 100 Research Avenue, Palo Alto, CA 94304, USA
Emergency Contact: CHEMTREC 1-800-424-9300, medical assistance at 1-800-555-1212
Classification: Reagents may carry health risks typical for laboratory chemicals; not classified as hazardous by GHS under expected laboratory conditions, but proper caution advised
Label Elements: No pictogram required; safety information indicated below
Signal Word: Caution
Hazard Statements: Prolonged or repeated exposure may irritate eyes and skin; ingestion may cause gastrointestinal discomfort
Precautionary Statements: Use personal protective equipment and avoid inhalation or ingestion
Buffer Solution: Tris(hydroxymethyl)aminomethane (CAS 77-86-1) 50-100 mM
Lysis Solution: Guanidine hydrochloride (CAS 50-01-1) 2-6 M; Triton X-100 (CAS 9002-93-1) 0.1-1%
Wash Buffer: Ethanol (CAS 64-17-5) 60-80%;
Enzyme Mix: Proteinase K, recombinant (CAS 39450-01-6), minimal hazard under normal use
Additional Components: Sodium chloride (CAS 7647-14-5), EDTA (CAS 60-00-4), small amounts as stabilizers
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present; seek medical advice if irritation persists
Skin Contact: Wash with plenty of soap and water; remove contaminated clothing and launder before reuse
Inhalation: Move person to fresh air; seek medical attention if respiratory symptoms occur
Ingestion: Rinse mouth thoroughly with water; do not induce vomiting; seek immediate medical assistance if symptoms develop
Most Important Symptoms: Eye, skin and upper respiratory tract irritation; in rare cases, allergic response
Suitable Extinguishing Media: Water spray, foam, carbon dioxide, dry chemical
Specific Hazards: Ethanol solutions may be flammable; avoid inhaling combustion products
Protective Equipment for Firefighters: Wear self-contained breathing apparatus, flame-resistant clothing and eye protection
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, hydrogen chloride, organic vapors
Personal Precautions: Wear gloves, protective eyewear, and lab coat
Environmental Precautions: Prevent release to drains, sewers, soil, or surface water
Methods for Clean-up: Absorb spills with inert material (sand, dry cloth); collect for proper disposal; wash spill site with water and detergent after material pickup
Additional Information: Ventilate area, minimize dust or aerosol generation
Handling: Work in well-ventilated area; avoid direct contact with skin and eyes; never eat, drink, or smoke in handling areas
Storage Conditions: Store in tightly closed containers in a cool, dry, and well-ventilated place; protect from sunlight and sources of ignition
Incompatible Materials: Strong oxidizers, strong acids or bases, reactive metals
Special Considerations: Keep containers sealed; do not reuse empty containers
Engineering Controls: Use in chemical fume hood or under local exhaust ventilation
Personal Protective Equipment: Nitrile or latex gloves, splash goggles, lab coat; use face shield during spill response
Exposure Limits: Ethanol TLV (ACGIH) 1000 ppm; no occupational limit for Tris buffer or proteinase under routine lab use
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing, avoid touching face before washing
Form: Liquid (buffers, lysis, wash solution), lyophilized powder (enzyme)
Color: Colorless, slight yellow tinge possible
Odor: Slight alcohol-like, no strong odor
pH: 7.2–8.5 (buffer), acidic for lysis solution
Melting / Freezing Point: Similar to water for most solutions
Boiling Point: 78 °C (ethanol solution), over 100 °C for aqueous buffers
Flash Point: 21 °C (ethanol in wash buffer)
Solubility: Completely miscible with water; enzymes dissolve on mixing
Density: About 1.0 g/cm3 (buffers)
Chemical Stability: Stable at recommended storage conditions; enzymes lose potency above room temperature
Reactivity: Product not reactive under normal handling
Hazardous Reactions: Lysis buffer reacts with oxidizers; exothermic release possible in contact with acids
Decomposition Products: May include oxides of carbon, nitrogen, and hydrogen chloride if combusted
Conditions to Avoid: Excessive heat, introduction of strong acids, bases, oxidizing agents
Acute Toxicity: Oral LD50 (rat) for guanidine hydrochloride ~475 mg/kg; proteinase K low acute toxicity at concentrations used
Skin Corrosion/Irritation: Prolonged exposure may cause mild irritation, lysis buffer causes more noticeable skin discomfort
Eye Damage/Irritation: Both ethanol and guanidine can irritate eyes
Respiratory Sensitization: Dust or aerosols of powders could irritate airways
Chronic Effects: Not expected at typical exposure; prolonged or repeated contact may cause skin dryness
Carcinogenicity: Ingredients not classified as carcinogens under IARC, ACGIH, NTP, or OSHA
Aquatic Toxicity: Ethanol and guanidine hydrochloride show moderate toxicity to fish and invertebrates at high concentrations
Persistence and Degradability: Most components degrade in the environment over time
Bioaccumulation Potential: Not significant for ingredients present
Other Adverse Effects: Large spills could affect microbial action in soil or water; avoid uncontrolled release
Waste Treatment Methods: Dispose as laboratory chemical waste in accordance with local, regional, and national regulations
Unused Product: Contact approved hazardous waste disposal contractor
Contaminated Packaging: Decontaminate containers with 10% bleach, rinse, then recycle or dispose per lab guidelines
Environmental Precautions: Do not pour down drains or mix with domestic refuse
UN Number: 1170 (ethanol solution)
UN Proper Shipping Name: Ethanol solutions (if over 24% ethanol by weight)
Transport Hazard Class: Flammable liquid (Class 3 for ethanol-containing solutions)
Packing Group: II or III depending on ethanol concentration and volume
Special Precautions: Package with leak-proof closure, use secondary containment during shipping
OSHA Hazard Communication: Classified as non-hazardous except for flammability of some solutions
TSCA Status: All ingredients listed or exempt
SARA Section 313: No components subject to reporting
California Proposition 65: Product does not contain chemicals known to the State of California to cause cancer or reproductive harm
Other Information: Product for R&D use only; not for drug, household, or food use
