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Product Name: HOLO-TRANSFERRIN HUMAN
Synonyms: Apotransferrin (Iron-saturated), Transferrin (Human, Holo form)
Product Code: Consult supplier-specific documentation
CAS Number: 8049-22-7
Relevant Uses: Laboratory reagent, diagnostic component, cell culture supplement
Manufacturer: Refer to supplier
Address: Specify supplier location
Emergency Contact: Refer to supplier issued phone number or supervisor
Email: Consult supplier or MSDS information source
GHS Classification: Not classified as hazardous according to current GHS criteria
Physical Hazards: None identified in solid, lyophilized, or aqueous states
Health Hazards: May cause mild respiratory irritation, slight skin or eye irritation; no chronic health hazard proven from regular laboratory use
Environmental Hazards: Not considered a hazard to the environment in small laboratory quantities
Label Elements: GHS pictograms: None; Hazard Statements: None; Precautionary Statements: Minimal standard laboratory caution recommended
Other Hazards: Product contains protein of human origin; good laboratory hygiene required
Main Ingredient: Human holo-transferrin protein, iron-saturated
Chemical Formula: C2918H4514N780O881S37 (approximate)
Concentration: Typically supplied as lyophilized powder or aqueous solution (purity >95%)
Additional Ingredients: Preservatives (trace, if formulated), saline or phosphate buffer, sometimes trace stabilizers such as sodium azide or EDTA; consult specific supplier
Impurities: Protein content verified by SDS-PAGE and trace contaminant tests; meets industry or pharmacopeia standards if used for clinical/diagnostic purposes
Inhalation: Move individual to fresh air, monitor for symptoms of respiratory irritation, seek medical help if symptoms persist
Skin Contact: Remove contaminated clothing, wash exposed area with soap and water, obtain medical attention if irritation develops
Eye Contact: Flush with copious amounts of water for at least 15 minutes, seek medical attention if irritation continues
Ingestion: Rinse mouth with water, do not induce vomiting unless instructed by medical personnel, seek professional assistance
Main Symptoms: Irritation, redness, discomfort; no records of systemic poisoning or allergic reaction in normal laboratory contexts
Notes for Medical Professionals: Symptomatic care recommended; hypoallergenic properties verified through clinical-grade purification
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: No specific restrictions; avoid methods that may spread contaminated material
Special Hazards: Proteinaceous material may combust to produce irritating fumes (oxides of carbon, nitrogen, sulfur)
Protective Equipment for Firefighters: Full protective gear, self-contained breathing apparatus
Explosion Data: Not explosive; no sensitivity to mechanical impact or static discharge in solid or liquid form
General Advice: Minimize dust generation, ventilate affected area, avoid inhaling combustion products
Personal Precautions: Use suitable personal protective equipment including gloves, safety goggles, lab coat
Emergency Procedures: Keep unnecessary personnel away, ventilate area
Spill Containment: Limit spread with absorbent materials (paper towels or spill pads), collect waste into biohazard bags for disposal
Cleanup Methods: Wipe or soak up, clean surfaces with soap and water or a laboratory disinfectant such as diluted bleach solution
Environmental Precautions: Avoid release into surface drainage or sewer systems; small laboratory amounts unlikely to impact environment
Decontamination: Disinfect surfaces, launder contaminated fabrics, dispose of cleaning materials in compliance with institutional protocols
Handling: Wear lab coat, gloves, and eye protection; avoid splashing, dust generation, and prolonged direct contact
Hygiene Measures: Wash hands after handling, avoid eating, drinking, or smoking in work areas, use fume hood for aerosol-generating procedures
Storage Conditions: Store at -20°C or lower for long-term stability, short-term stability at 2–8°C; protect from moisture and light; reseal containers firmly after use
Incompatible Materials: Strong oxidizers, acids, bases
Special Storage Requirements: Use desiccant packs in storage containers if lyophilized; keep solutions sterile by using autoclaved containers and minimizing repeated freeze-thaw cycles
Occupational Exposure Limits: No specific occupational exposure limits established
Engineering Controls: Standard laboratory ventilation, use of biosafety cabinet for open handling
Respiratory Protection: Not required under normal laboratory conditions; use N95 mask if generating aerosols or handling large quantities
Skin Protection: Nitrile or latex gloves, impermeable lab coat; double-gloving for high-volume handling
Eye Protection: Chemical splash goggles or face shield
Other Protective Equipment: Emergency eyewash and safety shower in proximity; closed-toed shoes in laboratory
Environmental Exposure Controls: Exhaust to approved fume hood, do not discharge large quantities to drain
Appearance: White to off-white lyophilized powder or colorless solution
Odor: Odorless or faint proteinaceous smell
Odor Threshold: Not applicable
pH: Typically between 7.0 and 8.0 in solution
Melting Point / Freezing Point: Not feasible to melt under normal lab conditions; degrades with heat
Boiling Point: Not applicable (decomposes)
Flash Point: Not available or applicable
Evaporation Rate: Not volatile
Flammability: Not readily flammable under standard handling
Relative Density: Not determined
Solubility: Soluble in water; insoluble in non-aqueous solvents
Partition Coefficient (n-octanol/water): Not applicable
Auto-ignition Temperature: Not determined
Decomposition Temperature: Decomposes with high heat, protein denaturation above 45°C
Viscosity: Comparable to water when dissolved
Chemical Stability: Stable under recommended storage conditions, sensitive to proteases and microbial contamination
Reactivity: Not reactive with most common laboratory substances in standard conditions
Possibility of Hazardous Reactions: None expected in use-concentrations/quantities
Conditions to Avoid: Excess heat, repeated freeze-thaw cycles, strong acids or alkali, oxidizers
Incompatible Materials: Oxidizing agents, strong acids, strong bases
Hazardous Decomposition Products: Combustion yields oxides of carbon, nitrogen, sulfur; no toxicologically meaningful byproducts in laboratory fire scenarios
Routes of Exposure: Skin, eyes, inhalation, ingestion
Acute Toxicity: No acute toxicity documented; product is a purified human-derived protein, not intended for injection
Skin Corrosion / Irritation: May cause mild irritation
Serious Eye Damage / Eye Irritation: May cause irritation
Respiratory Sensitization: Not classified as respiratory sensitizer
Skin Sensitization: Not classified as skin sensitizer
Germ Cell Mutagenicity: No data to suggest mutagenic activity
Carcinogenicity: Not classified as carcinogen by IARC, NTP, ACGIH, or OSHA
Reproductive Toxicity: No evidence of reproductive or developmental toxicity
Repeated Dose Toxicity: Not observed in laboratory practice
Medical Conditions Aggravated by Exposure: No known aggravation; general protein allergies are extremely rare for laboratory users
Toxicity: Not anticipated to be toxic to aquatic life in dilute laboratory-scale quantities
Persistence and Degradability: Readily biodegradable; proteins are broken down by environmental enzymes and microbes
Bioaccumulative Potential: Not bioaccumulative, rapidly metabolized and decomposed
Mobility in Soil: Binds to soil proteins and organic matter, denatures outside lab conditions
Results of PBT and vPvB Assessment: Not considered persistent, bioaccumulative, or toxic
Other Adverse Effects: No significant adverse environmental impact in small research or clinical lab settings
Waste Treatment Methods: Dispose of through approved chemical waste disposal system; treat as biological waste
Waste Container Requirements: Clearly labeled biohazard bags or containers
Decontamination: Deactivate with dilute bleach prior to drain disposal when permitted by regulations, or incinerate
Disposal of Contaminated Packaging: Dispose of empty and cleaned containers per institutional and regulatory guidance
Additional Notes: Adhere to local, state, and national regulations; minimize environmental release; document disposal for compliance audits
UN Number: Not regulated for transport as dangerous good
UN Proper Shipping Name: Protein, not otherwise specified
Transport Hazard Class: Not applicable
Packing Group: Not assigned
Environmental Hazards: None
Special Precautions for User: Keep container tightly sealed, shield from extreme temperatures, ship with sufficient ice packs or dry ice for temperature-sensitive formulations
Transport in Bulk: Not relevant for this product in research or clinical settings
Safety, Health, and Environmental Regulations: Follows general laboratory chemical safety guidelines; not specifically regulated as hazardous chemical
OSHA: Not listed as hazardous
TSCA: Not listed
SARA Title III: Not listed
California Proposition 65: Not listed
REACH Regulation: Exempt as a naturally occurring human protein for research/diagnostic use; registration not required
Other International Regulations: Consult regulations applicable to protein reagents in each jurisdiction
Labelling According to EC Directives: Not required; good laboratory hygiene and practice essential
Chemical Safety Assessment: Not required for dilute proteins in non-pharmaceutical use
