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Product Name: Histopaque
Catalog Number: 1077 (common for Research categories)
Other Names: Polysucrose solution, Ficoll-Paque equivalent
Recommended Use: Density gradient centrifugation for separation of blood components
Manufacturer: Sigma-Aldrich
Address: 3050 Spruce Street, St. Louis, MO 63103 USA
Contact Number: 1-314-771-5765 (USA)
Emergency Phone: CHEMTREC: 1-800-424-9300
GHS Classification: Not classified as hazardous under GHS standards for this material
Main Hazards: May cause skin, eye, and respiratory tract irritation; not considered acutely toxic; not sensitizing
Label Elements: Signal word not required; no pictogram needed
Precautionary Statements: Avoid breathing vapors, mist, or spray; wash hands thoroughly after handling; use only outdoors or in well-ventilated area
Component: Polysucrose, CAS No. 26873-85-8, >85%
Component: Sodium diatrizoate, CAS No. 737-31-5, <15%
Water: Purified, to 100%
Impurities: None expected at hazardous levels
Mixture: Aqueous solution; no ingredients classified as carcinogenic, mutagenic, or reproductive toxin according to IARC, ACGIH, NTP, or OSHA
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if easy to do; continue rinsing; seek medical attention if irritation persists
Skin Contact: Wash area with soap and water; remove contaminated clothing; get medical attention if skin reaction occurs
Inhalation: Move person to fresh air; provide oxygen if breathing is difficult; get medical attention if symptoms linger
Ingestion: Rinse mouth with water; do not induce vomiting; never give anything by mouth to an unconscious person; seek immediate medical care if feeling unwell
General Advice: In all cases, consult a healthcare professional if symptoms develop or persist
Suitable Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide
Unsuitable Extinguishing Media: No restrictions known
Specific Hazards: In a fire, may emit irritating or toxic fumes of carbon oxides, nitrogen oxides, iodine compounds
Protective Equipment: Firefighters should wear full protective gear including self-contained breathing apparatus
Special Procedures: Cool containers with water spray to prevent pressure build-up and possible explosion in heat exposure
Personal Precautions: Avoid generating dust, vapors, or mist; wear protective gloves, safety glasses, and a laboratory coat
Environmental Precautions: Do not allow product to enter drains, surface water, or soil
Cleanup Methods: Absorb spill with inert material (e.g., sand, earth, vermiculite); collect in a suitable, closed, labeled waste container; ventilate area and wash spill site after material pickup
Other Information: Report releases as required under local environmental regulations
Handling: Handle in accordance with good laboratory hygiene and safety practices; avoid breathing vapor, mist, or spray; avoid contact with eyes, skin, and clothing; ensure adequate ventilation in working area
Storage: Store at 2–8°C in a tightly closed container; protect from light and moisture; keep away from incompatible materials; label containers clearly
Incompatibilities: Strong oxidizers and acids
Occupational Exposure Limits: No established exposure limits for components; use caution due to limited data
Engineering Controls: Work in a chemical fume hood, or ensure adequate local exhaust ventilation
Personal Protective Equipment: Chemical-resistant gloves, safety goggles, lab coat; use NIOSH/MSHA-approved respirator if exposure limits are exceeded or ventilation is inadequate
Hygiene Measures: Wash hands after handling; remove and wash contaminated clothing before reuse
Appearance: Clear, colorless to pale yellow viscous liquid
Odor: None
pH: 7.0-7.5 (typical)
Boiling Point: Approximately 100°C
Melting/Freezing Point: Below 0°C
Flash Point: Not flammable
Solubility: Completely soluble in water
Density: Approximately 1.077 g/mL
Viscosity: High, depending on concentration
Vapor Pressure: Similar to water at 20°C
Other Properties: Non-volatile, non-explosive
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not reactive under normal use; no hazardous polymerization anticipated
Conditions to Avoid: Heat, moisture, direct sunlight, incompatible materials
Incompatible Materials: Strong acids, strong oxidizers
Hazardous Decomposition: Emits CO, CO2, NOx, and iodine compounds under fire conditions
Acute Toxicity (Oral, Dermal, Inhalation): Low toxicity expected; data limited for primary components
Skin/Eye Irritation: May cause mild irritation; not expected to cause sensitization
Chronic Effects: Not known to cause long-term health effects; not classified as carcinogenic, mutagenic, or reproductive toxin
Symptoms: Contact may result in redness, itching, or discomfort; inhaling high concentrations can cause mild respiratory symptoms
Medical Conditions Aggravated: Individuals with pre-existing skin, eye, or respiratory conditions may be more susceptible
Aquatic Toxicity: No available data suggest significant hazard to aquatic organisms
Persistence and Degradability: Readily biodegradable; polysucrose and sodium diatrizoate expected to degrade in environment
Bioaccumulation: Not expected to bioaccumulate
Mobility in Soil: High solubility in water; likely to migrate in aquatic systems
Other Adverse Effects: Avoid uncontrolled release to the environment
Waste Treatment Methods: Dispose of in accordance with local, regional, and national regulations; do not discharge to drains or water bodies
Container Disposal: Rinse container and dispose as hazardous laboratory waste
Recommended Practices: Contact licensed waste disposal company; incineration or appropriate landfill as approved by local authorities
Precautions: Avoid contamination of the environment; document all disposal procedures
UN Number: Not regulated for transport
UN Proper Shipping Name: Not classified as a dangerous good
Transport Hazard Class: None assigned
Packing Group: None assigned
Special Precautions: Ensure containers are leakproof and tightly sealed during transport; avoid excessive temperatures
Additional Info: No transport-specific hazards identified
United States (OSHA/HCS): This material is not considered hazardous
TSCA: Components listed or otherwise in compliance
SARA 313: Not subject to reporting
California Proposition 65: Not listed
Europe (ECHA/REACH): Components registered or pre-registered
Canada (DSL/NDSL): Components appear on DSL
Other Regulations: No restricted substances; comply with national and local chemical safety rules
