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Product Name: Histopaque-1077
Synonyms: Density Gradient Medium for Cell Separation
Product Code: Varies by supplier
Recommended Use: Lab reagent for isolating lymphocytes, monocytes, and other cells from blood
Manufacturer: Sigma-Aldrich, Thermo Fisher, or respective local supplier
Contact Information: Emergency telephone number, website, address (consult packaging for details)
CAS Number: 1318-00-9 (Polysucrose), 77-86-1 (Tris), 56-81-5 (Glycerol), 60-00-4 (EDTA)
UN Number: Not regulated for transport
Classification: Not classified as hazardous under GHS or OSHA regulations
Main Hazards: Non-flammable, mild skin and eye irritation, ingesting can lead to minor gastrointestinal upset, possible mild respiratory irritation if aerosolized and inhaled
Label Elements: May display caution for eye contact, skin contact
Icons: Exclamation mark for minor irritation (if required by region)
Most Important Hazards: Prolonged exposure may trigger slight discomfort, otherwise low acute toxicity
Other Hazards: Extremely low environmental persistence, not reactive, does not present explosion risk
Polysucrose: approx. 55-70% by weight, used as a density gradient compound (CAS 1318-00-9)
Sodium Diatrizoate: approx. 25-40% by weight, secondary density medium (CAS 737-31-5)
Tris (tris(hydroxymethyl)aminomethane): minor (<1%) buffer agent (CAS 77-86-1)
Glycerol: minor (<1%) stabilizer (CAS 56-81-5)
EDTA, Disodium Salt: trace (<0.1%) chelating agent (CAS 60-00-4)
Water: balance to 100%
Impurities: Not regarded as hazardous in this mixture
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if easy, seek medical advice if irritation persists
Skin Contact: Wash with soap and water, remove contaminated clothing and launder before reuse, seek medical advice for persistent redness or irritation
Inhalation: Move to fresh air, keep at rest, consult a physician if symptoms manifest
Ingestion: Rinse mouth with water, drink several glasses of water, do not induce vomiting, seek medical attention if discomfort develops
Most Important Symptoms: Redness, mild irritation of eye or skin, mild throat irritation from inhalation
Acute/Delayed Effects: Acute symptoms usually resolve with basic first-aid; no anticipated long-term effects
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide suited for surroundings
Unsuitable Media: No restrictions, choose based on surrounding materials
Specific Hazards: Histopaque-1077 itself is non-combustible, packaging may burn
Hazardous Combustion Products: Carbon oxides, nitrogen oxides possible if burned
Protective Equipment: Full protective suit and breathing apparatus recommended for fire-fighters
Special Procedures: Cool exposed containers with water spray, avoid inhaling smoke or fumes
Personal Precautions: Use gloves, eye protection, avoid direct contact
Environmental Precautions: Avoid discharge into drains, surface water, or groundwater
Methods for Cleaning Up: Contain spill with absorbent material (paper towels, vermiculite), collect for disposal, wash area with water
Spill Size Considerations: For large spills, use preventive barriers, ventilate area
Disposal: See section on Disposal Considerations for further guidance
Handling: Keep container tightly closed, use in well-ventilated space, avoid inhaling vapors, avoid prolonged or repeated direct skin or eye contact
Storage Conditions: Store at 4°C–25°C per supplier’s recommendations, protect from light, do not freeze, use original container
Incompatible Materials: Strong oxidizing agents, extreme heat
Precautions: Keep away from food and drink, handle according to laboratory hygiene standards
Exposure Limits: Not assigned for this product or main components; general lab hygiene standards apply
Engineering Controls: Use with local exhaust ventilation or in fume hood to minimize aerosol exposure
Personal Protective Equipment: Laboratory gloves (nitrile or latex), safety goggles, laboratory coat
Respiratory Protection: Not generally required under normal lab practice, use mask if aerosol risk exists
Hygiene Measures: Wash hands thoroughly after handling, remove soiled clothing and clean before reuse
Appearance: Clear to slightly yellow liquid
Odor: Odorless or faint sweet odor
pH: 7.0–7.3 at 25°C
Melting Point/Freezing Point: Below 0°C, avoid freezing
Boiling Point: Above 100°C
Flash Point: Not flammable
Evaporation Rate: Similar to water
Solubility: Fully miscible in water
Vapor Pressure: Similar to water at room temperature
Viscosity: Higher than water due to polysucrose content
Density: 1.077 g/mL at 25°C
Partition Coefficient: Not applicable, product dissolves in water
Chemical Stability: Stable under normal laboratory and storage conditions
Hazardous Decomposition Products: Releases carbon oxides, nitrogen oxides if overheated or burned
Incompatible Materials: Avoid strong oxidizers and acids, excessive heat, freezing conditions
Reactivity: Low reactivity under ambient conditions
Polymerization: Will not occur
Acute Toxicity Estimates: Data limited, anticipated to have low acute toxicity based on components
Routes of Exposure: Skin and eye contact, ingestion, inhalation if aerosolized
Irritation: Mild to moderate skin or eye irritation possible with direct contact
Chronic Exposure: None expected under approved lab practice
Sensitization: Not classified as skin or respiratory sensitizer
Carcinogenicity/Mutagenicity: Not listed as carcinogenic or mutagenic by IARC, NTP, or OSHA
Other Effects: Ingestion may cause mild digestive upset, massive ingestion may require medical observation
Ecotoxicity: Not expected to pose a hazard to aquatic life or environment due to low concentrations and rapid dilution
Persistence/Degradability: Readily biodegradable components, not anticipated to bioaccumulate
Mobility: High mobility in water, dilute solutions expected rapidly in sewage system
Bioconcentration: Negligible, not expected to accumulate in living organisms
Other Adverse Effects: Avoid unauthorized release into drains and natural water sources; follow standard lab disposal policy
Waste Disposal Methods: Dispose of according to local, regional, and national regulations for laboratory waste
Product Disposal: Flush small volumes (diluted) in laboratory drains with copious water, larger volumes collect for chemical waste collection
Packaging Disposal: Rinse and dispose of as laboratory or recyclable waste if clean, else treat as contaminated chemical waste
Precautions: Do not dispose with domestic garbage or landfill, follow laboratory biosafety and chemical safety guidelines
UN Number: Not regulated as hazardous for transport
UN Proper Shipping Name: No dangerous goods label required
Transport Hazard Classes: Not classified
Packing Group: None
Special Precautions: Prevent freezing during shipment, keep upright, ensure containers are tightly sealed
Environmental Hazards: Avoid spillage during transport
OSHA Status: Not considered hazardous
WHMIS Classification: Not controlled under WHMIS (Canada)
GHS Classification: Not hazardous by UN GHS
Inventory Status: All ingredients listed in TSCA (US), EINECS (EU), DSL (Canada), AICS (Australia), ENCS (Japan)
Other Regulatory Listings: Not subject to SARA, CERCLA, RCRA (US standards)
Labeling Requirements: General laboratory safety labels, not required for hazardous pictograms or statements based on current classification
