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Product Name: Hexamethylenetetramine
Synonyms: Methenamine, Urotropine
Chemical Formula: C6H12N4
CAS Number: 100-97-0
Recommended Use: Used in making phenolic resins, explosives, solid fuel tablets, corrosion inhibitors, rubber vulcanization, and as a urinary antiseptic
Supplier Details: Manufacturer name, address, and emergency contact phone number on supplied documentation
Emergency Number: Refer to regional poison control or company emergency hotline
REACH Registration Number: Provided on supplied regulatory documents
Classification: Flammable solid (Category 2), Irritant to skin, Serious eye irritant, May cause respiratory irritation
Label Elements: Signal word: Warning; Pictograms: Flame, Exclamation Mark
Hazard Statements: May form combustible dust concentrations in air, causes skin and eye irritation, may cause allergy or asthma symptoms, may damage organs through prolonged or repeated exposure
Precautionary Statements: Keep away from heat and ignition sources, avoid breathing dust, wear appropriate protective gear, keep container tightly closed
Health Hazards: Dust can irritate mucous membranes, large exposures may trigger systemic symptoms
Environmental Hazards: Toxic to aquatic organisms in concentrated spills; avoid uncontrolled release into environment
Chemical Name: Hexamethylenetetramine
Concentration: 99-100%
Impurities or Additives: None significant for usual commercial grades
EC Number: 202-905-8
Molecular Weight: 140.19 g/mol
Other Ingredients: No significant stabilizers, binders, or excipients included in pure material
Inhalation: Move person to fresh air, keep at rest, seek medical advice if symptoms continue; watch for coughing, throat irritation, and difficulty breathing
Skin Contact: Remove contaminated clothing, wash skin with soap and water for at least 15 minutes, consult healthcare provider if skin irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, contact eye care specialist if eye irritation persists
Ingestion: Rinse mouth, seek medical attention if you feel unwell, do not induce vomiting unless instructed by medical personnel
Most Important Symptoms: Redness, itching, swelling of skin and eyes, cough or sore throat after inhaling dust
Suitable Extinguishing Media: Water fog, alcohol-resistant foam, dry powder, or carbon dioxide extinguishers
Unsuitable Media: Do not use direct water jets as product is powdered and may spread
Special Hazards: During combustion, emits toxic fumes including formaldehyde, ammonia, nitrogen oxides
Advice for Firefighters: Wear full protective gear including independent breathing apparatus, avoid inhaling combustion products
Additional Advice: Containers exposed to fire may burst from pressure buildup; cool nearby containers with water spray
Personal Precautions: Evacuate unnecessary personnel, ensure use of protective clothing including gloves, goggles, and suitable respirator
Environmental Precautions: Do not allow to enter drains, surface water, or soil; use containment to prevent environmental contamination
Cleanup Procedures: Use spark-proof tools, pick up mechanically and place in labeled disposal containers; use damp methods to eliminate dust formation; ventilate area thoroughly after cleanup
Additional Measures: Dispose according to local, regional, national, and international regulations for hazardous waste
Handling: Wear appropriate personal protective equipment; avoid generating dust; handle in a well-ventilated area; keep away from open flames, hot surfaces, and sources of ignition
Storage: Store in tightly sealed containers in a cool, well-ventilated, dry place; keep separate from strong oxidizers, acids, and reducing agents; avoid direct sunlight and moisture
Incompatible Materials: Strong acids, strong oxidizing agents, water under storage conditions that may lead to hydrolysis
Specific Use Recommendations: Keep containers closed when not in use, store at temperature below 25°C for extended shelf life
Exposure Limits: No established US OSHA PEL, ACGIH TLV, or NIOSH REL; consider workplace guidelines for dust exposure (e.g., total dust TLV: 10 mg/m3)
Engineering Controls: Use local exhaust ventilation to minimize airborne dust; use explosion-proof equipment
Personal Protective Equipment: Eye protection (goggles or full-face shield), gloves (chemical resistant such as nitrile), lab coat or chemical-resistant clothing, appropriate dust mask or respirator (P2/P3 filters) if dust is generated
Hygiene Measures: Do not eat, drink, or smoke while handling this product; wash hands and exposed skin thoroughly after use; provide eyewash stations and safety showers in the immediate work area
Appearance: White crystalline powder or colorless crystals
Odor: Practically odorless
Odor Threshold: Not determined
Melting Point: 280–285°C (decomposes before melting)
Boiling Point: Sublimes at 263°C
Solubility: Freely soluble in water (37 g/100 ml at 25°C), soluble in chloroform and ethanol, slightly soluble in ether
Vapor Pressure: Negligible at room temperature
Density: 1.33 g/cm³ at 20°C
pH (1% Solution): 8–9
Flash Point: 250°C (closed cup)
Auto-Ignition Temperature: 410°C
Partition Coefficient Log Kow: -2.18
Other Data: Not explosive in raw state, but dust-air mixtures may explode
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Reacts with strong oxidizers, acids (releases toxic gases)
Hazardous Reactions: Dust may pose risk of explosion; strong acid contact may result in formaldehyde release
Conditions to Avoid: High temperatures, moisture, open flames, sparks, ignition sources
Incompatible Materials: Strong oxidants, acid chlorides, strong acids, water when moisture-sensitive
Hazardous Decomposition Products: Ammonia, formaldehyde, nitrogen oxides in fire
Acute Toxicity: Oral LD50 (rat): 9200 mg/kg; unlikely to cause acute toxicity in small accidental exposures
Irritation: Contact may cause redness and pain in skin and eyes; inhaling dust can cause nasal and respiratory irritation
Sensitization: Prolonged or repeated exposure may produce allergic reactions, including asthma-like symptoms
Chronic Effects: Chronic overexposures may affect kidneys and bladder; rare cases of methemoglobinemia reported
Carcinogenicity: Not classified as a carcinogen by IARC, NTP, or OSHA
Reproductive Toxicity: No evidence found in animal studies at typical doses
Mutagenicity: Some assays suggest weak mutagenic effects, not considered significant for normal exposure
Ecotoxicity: Fish LC50 (96h): 500 mg/L; Daphnia EC50 (48h): 36 mg/L; Algae EC50 (72h): 20 mg/L
Aquatic Effects: Material poses a moderate risk to aquatic organisms if released in large amounts
Degradability: Readily biodegradable in most surface water conditions
Bioaccumulative Potential: Low, estimated bioconcentration factor (BCF) is negligible
Mobility in Soil: High mobility in soil and water due to good solubility; potential for leaching
Other Adverse Effects: No ozone depletion or global warming potential identified
Waste Treatment Methods: Dispose as hazardous chemical waste in accordance with local, state, national, and international regulations; incinerate under controlled conditions preferred
Contaminated Packaging: Rinse empty containers thoroughly, dispose of in line with chemical waste protocols; do not reuse packaging for food or drink
Other Disposal Recommendations: Avoid disposal in sewage or surface water; consider professional waste disposal contractors for bulk quantities
UN Number: 1328
UN Proper Shipping Name: Hexamethylenetetramine
Transport Hazard Class: 4.1 (Flammable solid)
Packing Group: III
Marine Pollutant: No
Special Precautions: Transport in tightly sealed, properly labeled containers; keep away from heat and open flames
Transport Labels: Flammable solid label and any required hazard markings per jurisdiction
GHS: Classified under UN GHS as a flammable solid, irritant
US TSCA: Listed on the Toxic Substances Control Act inventory
REACH: Registered, restrictions may apply in the European Union depending on use
OSHA: Considered hazardous due to irritant and flammable properties
Other Country Regulations: Specific regulations may apply in Canada (DSL listed), Australia (AICS listed), Japan (ENCS listed), China (IECSC listed)
Right-to-Know: Listed on state and provincial right-to-know inventories in North America
Other Regulatory Data: Workplace exposure monitoring and risk assessments suggested in many regions; consult local laws
