© 2026 Nanjing Finechem Holdings Co., Ltd,
All Right Reserved
Chemical Name: Hesperidin
Chemical Formula: C28H34O15
Common Uses: Found in citrus peels, widely used as a dietary supplement and in nutraceuticals.
Appearance: Pale yellow crystalline powder, lacks odor, tastes slightly bitter.
Synonyms: Bioflavonoid, Citrus Bioflavonoid Complex, Hesperetin 7-rutinoside
Natural Occurrence: Oranges and lemons carry high concentrations.
Globally Harmonized System Classification: Does not fall under highly hazardous chemicals.
Main Hazards: Inhalation of powder may cause temporary respiratory discomfort. Skin contact rarely triggers irritation unless an individual already deals with extreme sensitivities. Ingestion in intended supplement amounts does not spark acute dangers for healthy adults.
Environmental Risk: Minimal for small-scale handling. Larger spills of fine powder near waterways deserve attention.
Notable Symptoms: Itching or redness if contact lasts for longer periods; coughing if powder dust floats around.
Content: Hesperidin in purified supplement grade often stands at over 95% purity.
Nature of Other Constituents: Trace amounts of citrus-derived substances, seldom any significant non-nutritional chemicals.
Hazardous Additives: Commercial offerings usually lack hazardous preservatives or colorants.
Eye Contact: Rinse carefully using water for a prolonged period, keeping eyelids open.
Skin Contact: Wash off with plenty of water and mild soap if powder lingers on exposed areas.
Inhalation: Escape exposure zone, seek fresh air, sit and breathe calmly.
Ingestion: Small quantities seldom result in issues, though excess consumption may require medical direction.
Medical Attention: Seek if redness, itching, breathing difficulty, or persistent symptoms arise.
Flammability: Dry hesperidin remains combustible; avoid open flames around powdered material.
Suitable Extinguishing Media: Use carbon dioxide, dry chemical, or fine water spray.
Preventive Actions: Remove containers from fire zone. Avoid breathing combustion fumes—natural substances like hesperidin, when burned, create irritating smoke.
Special Equipment: Firefighters benefit from standard protective gear and self-contained respiratory protection.
Personal Protection: Wear a dust mask, eye guards, and gloves to cut down on direct exposure.
Containment: Sweep spilled powder carefully, avoid raising dust. Gather with a damp cloth or mop preferably.
Cleanup: Wash the area with water to remove residue. Ventilate space if a significant spill creates dust.
Disposal of Collected Material: Collect waste in designated containers for appropriate disposal; avoid flushing in sewer.
Storage Conditions: Keep tightly closed in a cool, dry, well-ventilated spot. Bright light and moisture speed up degradation.
Handling Technique: Minimize dust creation by keeping the lid closed. Pour and measure in ventilated locations. Wash hands after contact.
Incompatibilities: Avoid exposure to oxidizing agents.
Engineering Controls: Use local exhaust or mechanical ventilation in processing spaces.
Personal Protection: Gloves, lab coats, and dust masks offer practical defense in workplaces with frequent handling. Eye protection such as safety spectacles comes in handy when weighing and transferring.
Workplace Exposure Limits: No specific governmental limits exist, but it helps to keep airborne particulate low as a general workplace rule.
Physical State: Crystalline powder
Color: Pale yellow
Odor: Absent or faintly citrus-like
Melting Point: Around 250°C (decomposes)
Solubility: Scarcely soluble in cold water, more so in hot water and ethanol.
Boiling Point: Not applicable (decomposes before boiling).
Density: Moderately dense (approx. 1.7 g/cm³).
Chemical Stability: Stable under recommended storage. Extended sunlight or humidity causes breakdown.
Reactivity: Neutral under normal handling. Mixing with oxidants, strong acids, or bases stirs up risks.
Decomposition Products: Irritating smoke, possible production of oxides of carbon under fire.
Acute Toxicity: Low risk for healthy adults in reasonable supplement exposure. High-dose consumption or chronic exposure remains poorly studied in vulnerable segments.
Irritation: Potential for mild eye or skin irritation if handled in large quantities.
Allergenicity: Rare, though individuals with severe citrus allergies may experience itchiness or rashes.
Additional Effects: Digestion of high doses may unsettle stomachs or disrupt regular digestion for sensitive individuals.
Fate in Environment: Biodegrades in natural settings, especially in soil and compost rich with microbial life.
Toxicity to Aquatic Life: Harm appears negligible at concentrations typical for dietary or laboratory use, though very large industrial releases could add organic load to waterways.
Bioaccumulation: Little evidence for buildup in organisms.
Waste Disposal: Small amounts can be mixed with household trash, though bulk unneeded powders demand collection by waste management teams specializing in non-hazardous materials.
Environmental Precaution: Avoid flushing into drains to reduce organic pollution spikes.
Packaging Disposal: Rinse and recycle or dispose containers per local policies.
Transport Regulation: Non-hazardous classification for road, sea, air, and rail.
Packing Guidance: Keep dry, tightly shut, protected from damage or contamination.
Spill Prevention: Avoid jostling or leaking by keeping containers upright and cushioned during movement.
Regulatory Status: Considered a safe dietary ingredient in many countries with guidelines for supplement use.
Labeling Guidance: Clear marking helps prevent accidental misuse, especially by those new to supplement ingredients.
Workplace Standards: Adherence to occupational safe handling recommendations keeps risks minimal for processors and supplement producers.
Consumer Awareness: Labels should mention natural origin and lack of hazardous components, but warn about dust and rare allergies.
