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Product Name: Guanidine Hydrochloride
Synonyms: Guanidinium chloride, Guanidine monohydrochloride
Chemical Formula: CH6ClN3
Molecular Weight: 95.53 g/mol
Recommended Uses: Laboratory reagent, protein denaturant, RNA isolation
Manufacturer: Supplier or manufacturer details should be referenced on packaging
Emergency Contacts: Local poison control center, fire department, workplace safety office
CAS Number: 50-01-1
Classification: Harmful if swallowed, causes skin and eye irritation, may cause respiratory irritation
Signal Word: Warning
Hazard Statements: H302: Harmful if swallowed. H315: Causes skin irritation. H319: Causes serious eye irritation. H335: May cause respiratory irritation.
Precautionary Statements: Avoid breathing dust. Wash hands thoroughly after handling. Use only outdoors or in well-ventilated area.
Pictograms: Exclamation mark symbol
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Hazard Rating: Health: 2, Flammability: 1, Reactivity: 0 (NFPA scale)
Chemical Name: Guanidine Hydrochloride
Concentration: ≥99% (pure)
CAS Number: 50-01-1
Additives/Impurities: No significant impurities expected in laboratory-grade material
Other Components: None reported in standard lab reagent grade
Inhalation: Move person to fresh air. Seek medical attention if symptoms like coughing, shortness of breath, or throat irritation develop.
Skin Contact: Remove contaminated clothing. Wash skin thoroughly with soap and water. Seek medical advice if irritation or redness persists.
Eye Contact: Rinse cautiously with water for at least 15 minutes, lifting eyelids. Remove contact lenses if present and easy to do. Continue rinsing. Get medical attention immediately.
Ingestion: Rinse mouth with water. Do not induce vomiting. Seek medical attention without delay. Give water to dilute only on advice from medical personnel.
Most Important Symptoms: Burning sensation, coughing, shortness of breath, skin redness, watering eyes
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, alcohol resistant foam
Unsuitable Extinguishing Media: No specific prohibitions, avoid direct water jet on product sample
Specific Hazards: Emits toxic gases like nitrogen oxides, hydrogen chloride on decomposition
Protective Equipment: Self-contained breathing apparatus, protective clothing resistant to chemicals
Special Procedures: Move containers from fire area if safe. Prevent runoff from entering drains or waterways. Stay upwind to avoid hazardous smoke.
Explosion Hazard: Not explosive under normal conditions, dust may present minor risk in confined spaces
Personal Precautions: Wear gloves, goggles, laboratory coats, and dust mask or appropriate respirator. Avoid skin and eye contact.
Environmental Precautions: Do not let product enter drains, watercourses, or soil. Use barriers to prevent entry into waterways.
Methods for Cleaning Up: Scoop up solid material carefully, avoid generating dust. Clean spill area with water, ventilate area during clean-up. Store residue in sealed, labeled waste container for disposal.
Emergency Procedures: Evacuate unnecessary personnel. Ensure adequate ventilation, especially in confined spaces.
Handling: Avoid inhaling dust or vapor. Avoid contact with skin, eyes, and clothing. Use proper personal protective equipment and handle in well-ventilated areas. Take steps to prevent dust buildup. Keep containers tightly closed. Good hygiene practices prevent accidental exposure; always wash hands before eating or touching face.
Storage: Store in a tightly closed container in a dry, cool, well-ventilated place. Keep out of reach of incompatible substances such as strong oxidizers and acids. Recommended storage temperature: Room temperature to below 30°C. Protect from direct sunlight and moisture. Secure shelving ensures containers will not fall or leak during storage.
Occupational Exposure Limits: No established limits for Guanidine Hydrochloride; handle as a nuisance dust (OSHA PEL for particulates not otherwise regulated: 15 mg/m³ total, 5 mg/m³ respirable fraction)
Engineering Controls: Use local exhaust ventilation, chemical fume hoods, or process enclosures. Maintain good air flow to minimize airborne concentrations.
Personal Protective Equipment: Gloves (nitrile, polyethylene), chemical safety goggles, laboratory coat, and dust-resistant mask or respirator for bulk handling
Hygiene: Wash hands, forearms, and face after handling. Prohibit eating, drinking, or smoking while using product. Emergency eyewash stations and showers should be accessible.
Environmental Controls: Prevent release into environment, secure all waste containers, and follow all regulatory guidelines for handling chemicals
Appearance: White or colorless solid, crystalline powder
Odor: Slightly amine-like
pH: Typically 5.0–6.0 (50 g/L aqueous solution at 20°C)
Melting point: 181–183°C (decomposes)
Boiling Point: Not applicable; decomposes before boiling
Solubility: Freely soluble in water, soluble in alcohol
Density: About 1.3 g/cm³ at 20°C
Vapor Pressure: Negligible at room temperature
Flash Point: Not flammable
Auto-ignition Temperature: Not self-igniting
Partition Coefficient (log Kow): -4.5 (low potential for bioaccumulation)
Evaporation Rate: Not volatile under standard conditions
Other Properties: Hygroscopic, absorbs moisture from air easily
Chemical Stability: Stable under recommended handling and storage conditions
Reactivity: Non-reactive with most common materials under normal use
Hazardous Polymerization: Not known to polymerize
Hazardous Decomposition Products: Nitrogen oxides, hydrogen chloride when heated or involved in fire
Incompatible Materials: Strong oxidizing agents, strong acids, bases
Conditions to Avoid: Excessive heat, humidity, contact with incompatible chemicals
Corrosivity: May be mildly corrosive to metals if wet
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: Oral LD50 (rat): 936 mg/kg
Skin Corrosion/Irritation: Causes irritation on contact
Eye Damage/Irritation: Can cause severe irritation and redness
Respiratory Sensitization: Dust or airborne particles may trigger cough, throat irritation; serious reactions rare unless exposure is high
Carcinogenicity: Not classified by IARC, NTP, or OSHA as carcinogenic
Mutagenicity/Genotoxicity: Limited data; not listed as genotoxic
Chronic Effects: Prolonged skin contact may cause dermatitis; inhalation of dust over extended period may lead to respiratory discomfort
Other Health Effects: Not known to cause allergic skin reactions
Ecotoxicity: Low acute toxicity to aquatic life based on available data; avoid uncontrolled release
Aquatic Toxicity: Not classified as dangerous for the environment but excessive amounts could cause local nutrient imbalances
Persistence and Degradability: Readily miscible with water and expected to degrade over time in natural settings
Bioaccumulation Potential: Low (log Kow -4.5)
Soil Mobility: Highly mobile in water; can migrate in soil if spilled
Other Adverse Effects: No evidence of ozone depletion or photochemical activity
Precaution: Prevent larger discharges into waterways. Practice responsible chemical management and spill containment.
Waste Treatment Methods: Dispose of as hazardous chemical waste according to local, regional, national, and international regulations
Packaging Disposal: Empty containers must be handled with care, triple-rinsed and disposed of as hazardous waste if contaminated
Methods of Disposal: Dissolve or mix with combustible material and incinerate in chemical incinerator equipped with afterburner and scrubber
Precautions: Do not allow discharge to sewer systems or surface water. Consult state and local environmental agencies for guidance on disposal matters.
UN Number: Not classified as hazardous for transport
Proper Shipping Name: Not regulated
Hazard Class: Non-hazardous (check with carrier for confirmation by region and quantity)
Packing Group: Not assigned
Marine Pollutant: Not listed as marine pollutant
Special Precautions: Avoid moisture during transit, use sturdy sealed packaging, affix clear chemical labels on all containers
TSCA Status: Listed
REACH Registration: Exempted or registered as permitted for laboratory
use
SARA 313: Not subject to reporting
California Proposition 65: Not listed
OSHA: Not regulated as hazardous chemical, handle as potentially harmful substance
Canadian WHMIS: Classified as D2B (Toxic materials causing other toxic effects)
European Union (GHS/CLP): Signal word “Warning,” hazard statements H302, H315, H319, H335, precautionary labels required
Other Regulatory Notes: Always check local, regional, and national regulations before handling, storage, or transportation; ensure workers receive safety training appropriate for chemical hazards present
