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Product Name: Freund's Adjuvant Complete
Product Code: FAC-001
Recommended Use: Laboratory reagent, immune system stimulation in animal research
Supplier: Research Chemicals Distributor
Emergency Phone: Local Poison Control Center or 24-hour Emergency Medical Services
Synonyms: Complete Freund’s Adjuvant, FCA
Prepared By: Laboratory Safety Compliance Officer
Classification: Eye irritation, Skin irritation, Sensitization, Environmental hazard
Signal Word: Warning
Hazard Statements: Causes skin irritation, May cause allergic skin reaction, May cause eye discomfort, Toxic to aquatic life with long-lasting effects
Pictograms: Exclamation mark, Environment
Precautionary Statements: Avoid contact with eyes, skin, and clothing. Prevent release to the environment. Use in well-ventilated area. Wear protective gloves and eye shield.
Key Ingredients: Mineral oil (CAS: 8042-47-5), Mannide monooleate (CAS: 25655-43-8), Heat-killed Mycobacterium tuberculosis H37Ra (CAS: 68424-05-3)
Percentage: Mineral oil 85%, Mannide monooleate 15%, Mycobacterium tuberculosis less than 1%
Impurities: None significant for safety reporting
Description: Suspension, milky white to yellowish
Inhalation: Remove to fresh air, monitor for difficulty breathing, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, gently wash with soap and plenty of water, seek medical advice if irritation develops
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present, continue rinsing, consult an eye specialist
Ingestion: Do not induce vomiting, rinse mouth with water, seek immediate medical care, show MSDS to healthcare personnel
Most Important Symptoms: Redness, pain, swelling at contact site, possible allergic response
Suitable Extinguishing Media: Carbon dioxide (CO2), dry chemical powder, alcohol-resistant foam
Unsuitable Media: Direct water stream, as oil-based composition may spread fire
Hazardous Combustion Byproducts: Carbon monoxide, carbon dioxide, particulate matter
Special Precautions: Firefighters wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Other Information: Keep containers cool by spraying with water spray, avoid inhaling vapors or fumes
Personal Precautions: Wear gloves, chemical splash goggles, lab coat. Avoid breathing vapor, mist, or dust.
Environmental Precautions: Prevent entry to sewers, drains, soil, and waterways
Methods for Cleanup: Use inert absorbent material such as sand or vermiculite to contain spill, collect and place in suitable container for disposal, ventilate area, wash spill site following removal of material
Reference to Other Sections: See protective measures under Handling and Exposure Controls
Precautions for Safe Handling: Handle in accordance with good laboratory practices. Avoid inhalation, ingestion, and contact with skin and eyes. Ensure adequate ventilation. Keep away from incompatible materials.
Storage Conditions: Store at 2–8°C in tightly sealed container, protected from direct sunlight, heat, and moisture.
Incompatibilities: Strong oxidizers.
Hygiene Practices: Wash hands and face before breaks and after handling product. Do not eat, drink, or smoke in area where material is handled.
Engineering Controls: Use fume hood or adequate local exhaust ventilation
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile), protective clothing (lab coat), safety goggles with side shields, suitable respiratory protection if exposure limits are exceeded or airborne allergenic particles may be present
Environmental Controls: Prevent product from entering drains, water sources, or soil.
Control Parameters: No established occupational exposure limits for ingredients; practice good laboratory hygiene.
Appearance: Milky white to pale yellow emulsion
Odor: Faint oily odor
Odor Threshold: Not available
pH: Not applicable
Melting Point/Freezing Point: Below 0°C
Boiling Point/Range: Greater than 100°C (water phase), not well-defined due to suspension nature
Flash Point: >200°C (closed cup, mineral oil base)
Evaporation Rate: Not determined
Flammability: Non-flammable under normal conditions
Vapor Pressure: Negligible at room temperature
Relative Density: ~0.9 (water=1)
Solubility: Insoluble in water, dispersible
Partition Coefficient (n-octanol/water): Not determined
Auto-Ignition Temperature: Not determined
Decomposition Temperature: Not determined
Viscosity: Thick, creamy
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Non-reactive under normal use
Hazardous Reactions: No known hazardous reactions with intended use
Conditions to Avoid: Heating, direct sunlight, strong oxidizing agents
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides from protein components
Materials to Avoid: Strong acids, strong bases, oxidizers
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Acute Toxicity: Skin irritation, sensitization, eye irritation. Not intended for human use; animal studies show immune system effects.
Chronic Effects: Repeated exposure increases risk of allergy, asthma-like symptoms, possible granuloma formation at injection sites
Carcinogenicity: Not classified as carcinogen by IARC, NTP, ACGIH, or OSHA
Mutagenicity: No mutagenic effects reported
Other Information: Not for use in humans. May cause adverse effects if misused.
Toxicity to Aquatic Life: May be toxic to aquatic organisms and cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Mineral oil and surfactants are not rapidly biodegradable
Bioaccumulation: Components expected to have limited potential for bioaccumulation
Mobility: Low mobility in soil, oil residues may persist
Other Adverse Effects: Avoid uncontrolled release into environment
Waste Treatment Methods: Dispose of in accordance with local, regional, or national regulations
Container Disposal: Empty containers should be decontaminated and recycled or discarded as hazardous waste
Recommended Disposal: Incinerate in controlled facility or collect in designated chemical waste containers
Precautions: Do not allow product to reach sewage systems, surface or groundwater
UN Number: Not regulated as dangerous good under current transportation guidelines
UN Proper Shipping Name: Not classified
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Environmental Hazards: Not designated as marine pollutant
Special Transport Precautions: Keep container upright and sealed; prevent spillage during transport
OSHA: Components exempt as laboratory chemical, handle as hazardous chemical
TSCA (USA): Ingredients listed or exempt
EU REACH: Not subject to registration (for research, non-commercial use)
WHMIS (Canada): D2B – Skin/Eye Irritant
SARA Title III: No components subject to reporting
Other Regulations: Comply with applicable country, state, and local laws for chemical, biological, and medical agents
