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Product Name: Fluoroshield with DAPI
Product Code: F6057
Recommended Use: Mounting medium for fluorescence microscopy
Manufacturer: Sigma-Aldrich
Emergency Contact: CHEMTREC: +1-800-424-9300
Address: 3050 Spruce Street, St. Louis, MO 63103, USA
Telephone Number: +1 800-325-3010
Classification: Eye irritation, category 2A; Skin irritation, category 2; Carcinogenicity, category 2 (due to DAPI component)
Label Elements: Exclamation mark, Health hazard pictogram
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, Causes skin irritation, Suspected of causing cancer
Precautionary Statements: Avoid breathing vapors, Wash hands thoroughly after handling, Use personal protective equipment as required
NFPA Ratings: Health: 2, Flammability: 0, Reactivity: 0
GHS Classification: DAPI component poses a mutagenic and toxic risk
Chemical Identity: Solution containing antifade mounting medium and DAPI
Key Components: Glycerol (50-70%), Tris Buffer (1-5%), DAPI (4′,6-diamidino-2-phenylindole, <1%), Propyl gallate (<1%)
CAS Numbers: Glycerol: 56-81-5, Tris Buffer: 77-86-1, DAPI: 28718-90-3, Propyl gallate: 121-79-9
Impurities/Stabilizers: No significant impurities present above regulatory thresholds
Mixture Description: Clear viscous liquid containing fluorescent DNA stain
Inhalation: Move affected person to fresh air, provide oxygen if breathing is difficult, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, flush skin with soap and plenty of water for at least 15 minutes, seek medical advice
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing, seek medical advice
Ingestion: Rinse mouth with water, do not induce vomiting without medical direction, call poison center or physician
Notes for Physician: Treat symptomatically based on judgment and patient’s response
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Hazardous Combustion Products: Carbon oxides, nitrogen oxides
Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Specific Hazards: Product is not flammable, but heating may cause hazardous fumes
Special Precautions: Fight fire from safe distance, prevent fire-fighting water from entering drains or watercourses
Personal Precautions: Wear protective gloves, goggles, and lab coat, avoid breathing vapors, ensure adequate ventilation
Environmental Precautions: Prevent spillage from entering soil, drains, surface, and ground water
Containment and Clean-Up: Absorb with inert material (sand or vermiculite), collect in suitable container for disposal, disinfect spill area, wash with water and detergent, ventilate area
Emergency Procedures: Restrict access until clean-up is complete, use recommended PPE
Precautions for Safe Handling: Use in well-ventilated environment, avoid contact with skin and eyes, do not eat, drink, or smoke around product, keep container tightly closed
Storage Conditions: Store at 2-8°C (refrigerated), keep away from heat, light, and incompatible materials, avoid freezing
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Hygiene Practices: Wash hands after handling, remove contaminated clothing promptly
Engineering Controls: Use laboratory fume hood or ensure local exhaust ventilation
Exposure Limits: Glycerol ACGIH TLV: 10 mg/m3 (mist); DAPI: No occupational exposure limits established
Personal Protective Equipment: Chemical-resistant gloves (nitrile), safety glasses or goggles, lab coat, appropriate respiratory protection if aerosol or vapor is present
Other Protection: Eyewash station and emergency shower accessible in the work area
Appearance: Clear blue liquid
Odor: Mild, characteristic
Odor Threshold: Not established
pH: 7.0-8.0
Melting Point/Freezing Point: Not determined
Boiling Point: Approximately 100°C
Flash Point: Not applicable (aqueous solution)
Evaporation Rate: Not determined
Flammability: Not flammable
Vapor Pressure: Not available
Solubility: Miscible with water
Partition Coefficient (n-octanol/water): Not available
Vapor Density: Not available
Relative Density: Approx. 1.26 g/cm3
Viscosity: Viscous
Chemical Stability: Stable under recommended storage conditions
Reactivity: No hazardous reactions under normal conditions
Conditions to Avoid: Excessive heat, direct sunlight, freezing
Incompatible Materials: Strong acids, bases, oxidizers
Decomposition Products: Toxic fumes of carbon oxides, nitrogen compounds can evolve under fire conditions
Polymerization: Will not occur
Acute Toxicity: Glycerol LD50 Oral (rat): 12600 mg/kg; Data on DAPI limited but suggests toxicity by inhalation, ingestion, or skin absorption
Skin Corrosion/Irritation: Irritating to skin
Serious Eye Damage/Irritation: Causes serious eye irritation
Sensitization: No data available
Germ Cell Mutagenicity: DAPI exhibits mutagenic activity by intercalating DNA
Carcinogenicity: DAPI is suspected to have carcinogenic potential
Reproductive Toxicity: No definitive data
Specific Target Organ Toxicity: No data
Symptoms: Irritation of eyes, skin, upper respiratory tract; prolonged or repeated exposure may cause adverse effects on genetic material
Aquatic Toxicity: Contains DAPI, which may be hazardous to aquatic life at high concentrations
Persistence and Degradability: Glycerol is biodegradable, DAPI persistence data not available
Bioaccumulative Potential: Expected to be low
Mobility in Soil: May move through soil and water based on water solubility
Other Adverse Effects: Avoid release into the environment; hazardous effects expected mainly from DAPI component
Waste Disposal Methods: Dispose of product and any contaminated material as hazardous chemical waste in accordance with local, regional, and national legislation
Recommended Disposal: Incinerate or use approved chemical waste contractor
Container Disposal: Rinse containers before disposal, do not reuse empty containers
Special Precautions: Prevent spillages from entering drains, waterways, or soil
UN Number: Not regulated for transport
Proper Shipping Name: Not classified as hazardous for transport under ADR/RID, IATA, IMDG
Transport Hazard Class: Non-hazardous
Packing Group: Not assigned
Environmental Hazards: Not a marine pollutant
Transport Precautions: Protect from physical damage, keep container upright and closed during transit
US Regulations: OSHA Hazard Communication Standard: This product meets criteria for hazardous chemicals
SARA Title III Sections 311/312: Immediate (acute) health hazard
TSCA Status: All components listed
WHMIS (Canada): Class D2A/D2B (toxic, irritant)
EU Regulations: GHS/CLP-R1272/2008 classified, DAPI labeled for suspect carcinogenic/mutagenic effects
Other Regulatory Information: Follow institutional and governmental safety practices for handling mutagenic agents and hazardous laboratory reagents; consult local waste management authorities for disposal
