© 2026 Nanjing Finechem Holdings Co., Ltd,
All Right Reserved
Chemical Name: Filipin III
Synonyms: Filipin Sodium Salt
Type: Polyene macrolide antibiotic produced by Streptomyces filipinensis
Physical Appearance: Yellowish powder, with a distinctive odor
Intended Use: Laboratory research, particularly for detection of unesterified cholesterol in cell membranes
Toxic Status: Toxic if swallowed or inhaled, skin and eye irritant
Health Hazards: Disrupts cell membrane integrity, neurotoxic in animal testing, damages tissues on contact, hazardous by all exposure routes
Risk of Sensitization: Direct handling may trigger allergic reactions with repeated or prolonged skin contact
Environmental Hazard: Harmful to aquatic organisms; disrupts microbial communities if disposed of carelessly
Main Ingredient: Filipin III, polyene antibiotic
Purity: Usually over 90% pure in research-grade preparations
Contaminants: Minor polyene analogs can appear due to fermentation or extraction, but Filipin III should dominate
CAS Number: 480-49-9
Molecular Formula: C35H58O11Na
Inhalation: Move to fresh air immediately, seek medical help if symptoms arise, avoid breathing dust
Ingestion: Rinse mouth thoroughly, do not induce vomiting, immediately get medical attention
Skin Contact: Wash with plenty of soap and water, remove contaminated clothing right away
Eye Contact: Rinse cautiously with water for several minutes, get medical attention if discomfort persists
Appropriate Extinguishing Media: Water spray, foam, dry powder, CO2 extinguishers
Special Hazards: Filpin III decomposes under fire conditions, giving off toxic fumes (carbon oxides)
Protective Gear for Firefighters: Full protective clothing and self-contained breathing apparatus are a must
Precautions: Keep unprotected personnel away; avoid inhaling combustion byproducts
Spill Response: Ventilate area, wear gloves and lab coat, avoid raising dust, use a damp towel or HEPA vacuum
Environmental Precaution: Prevent runoff into drains or surface water, sweep up and place in appropriate waste container
Decontamination: Clean area with detergent and water after material is removed, discard cleanup media as hazardous waste
Handling: Work in a chemical fume hood, wear gloves and eye protection, minimize dust generation
Storage: Store tightly closed in a cool, dry place, protected from light, segregate from acids and oxidizers
Incompatibility: Avoid contact with strong acids, bases, and oxidizing agents to prevent hazardous reactions
Engineering Controls: Use only in a certified chemical fume hood or similar local ventilation
Personal Protection: Nitrile or latex gloves, chemical splash goggles, lab coat; respiratory protection if adequate ventilation isn’t possible
Hygiene:** Wash hands before breaks and after handling, don’t eat, drink, or smoke around the material
Appearance: Yellowish amorphous powder
Odor: Musty, antibiotic-like
Solubility: Soluble in dimethyl sulfoxide, ethanol, and methanol; poor solubility in water
Melting Point: Decomposes before melting
Stability: Sensitive to light and air, best stored sealed and refrigerated
Chemical Stability: Stable only in the dark and when protected from oxygen, breaks down under heat or light
Hazardous Reactions: Oxidizes quickly when exposed to strong oxidants; decomposes with acid/base treatment
Decomposition Products: Toxic gases such as CO and CO2 if burned, aggressive degradation under strong acid/base
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Effects: Irritation of skin, mucous membranes, and eyes, potential for severe tissue damage
Chronic Effects: Repeated exposure can damage the liver, kidneys, and nervous system based on animal studies
Carcinogenicity: Data unclear due to primary use as a research tool, not approved for human use
Special Risks: Not for therapeutic use, must avoid any risk of ingestion or injection
Effect on Aquatic Life: Toxic to microorganisms and possibly small invertebrates if released into waterways
Persistence/Degradability: Degrades slowly buried in soil or dumped in landfill, breaks down faster in well-aerated water
Bioaccumulation:** Unlikely due to relatively high solubility in organic solvents, but no definitive studies in natural environments
Overall Impact: Better to avoid any discharge outside controlled lab conditions
Disposal Method: Collect contaminated material in labeled hazardous waste container, incinerate in licensed facility
Do Not Dump: Never pour solutions down the drain, do not throw away with regular trash
Regulatory Caution: Local regulations override lab guidelines, check with institutional safety officers
Transport Regulation: Ship as hazardous chemical, double-bag and use padded secondary containers
Packaging:** Use unbreakable inner vessel inside shatterproof outer packaging to prevent accidental release
Labelling: Proper chemical hazard and biohazard symbols must appear clearly on outer packaging
Special Caution: Keep away from sunlight, heat, and rough handling during movement
Legal Status:** Not approved for food, drug, or cosmetic use, strictly regulated as a laboratory-only chemical
Worker Protection: Subject to occupational exposure limits, institutions must train staff in safe handling
Reporting Requirements: Hazardous material status triggers notification and documentation under most national and international trafficking protocols
