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Product Name: Ficoll-Paque Plus
Product Number: 17-1440-02
Recommended Use: Density gradient separation of lymphocytes
Supplier: Cytiva (formerly GE Healthcare Life Sciences), Marlborough, MA, USA
Contact Information: 1-800-526-3593 (USA), +1-800-345-5226 (Europe)
Emergency Contact: CHEMTREC: 1-800-424-9300 (US, Canada); +1-703-527-3887 (International)
GHS Classification: Not classified as hazardous according to OSHA 29 CFR 1910.1200
Label Elements: No pictogram, hazard statement, or signal word required
Health Hazards: May cause mild irritation to mucous membranes, eyes, skin with direct contact; ingestion or inhalation unlikely to pose significant acute risk under normal laboratory use
Physical Hazards: Not considered flammable or combustible
Ficoll 400: 5-15% (CAS No. 26873-85-8)
Sodium Diatrizoate: 10-25% (CAS No. 737-31-5)
Water: 60-85% (CAS No. 7732-18-5)
Other Ingredients: Contains minor preservatives, which are not present at concentrations classified as hazardous
Eye Contact: Flush eyes immediately with plenty of water for at least 15 minutes, seek medical attention if irritation persists
Skin Contact: Wash area with soap and water, remove contaminated clothing, seek advice if symptoms develop
Inhalation: Move to fresh air, get medical assistance if respiratory symptoms develop
Ingestion: Rinse mouth, drink water, do not induce vomiting, consult a physician if discomfort persists
Suitable Extinguishing Media: Water, dry chemical, foam, carbon dioxide
Unsuitable Extinguishing Media: None known for this product
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, and sodium compounds
Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Personal Precautions: Use appropriate personal protective equipment, avoid breathing vapors or contacting skin and eyes
Environmental Precautions: Do not allow product to enter drains, surface water, or soil
Spill Cleanup Methods: Absorb with inert material, scoop or sweep up, place in appropriate waste container, wash spill site with water after removal
Handling: Avoid contact with skin, eyes, and clothing; use in well-ventilated areas, practice good laboratory hygiene
Storage Conditions: Store between 2°C and 8°C in a tightly closed container; keep away from strong acids and bases, incompatible materials, and direct sunlight
Special Requirements: Do not freeze, keep container tightly sealed to avoid contamination or evaporation
Exposure Limits: No occupational exposure limits established for primary ingredients
Engineering Controls: General laboratory ventilation sufficient, use fume hood if risk of aerosol formation exists
Personal Protective Equipment: Lab coat, safety glasses, gloves (nitrile or latex), avoid creation of splashes or dust
Hygiene Measures: Wash hands thoroughly after handling, do not eat, drink, or smoke while using the product
Appearance: Clear, colorless to pale yellow solution
Odor: Odorless
pH: 7.1-7.3
Boiling Point: Similar to water (>100°C)
Melting Point/Freezing Point: Approx. 0°C (due to water content, do not freeze)
Vapor Pressure: Not determined
Solubility: Completely miscible with water
Density: Approx. 1.077 g/mL (at 20°C)
Evaporation Rate: Not determined
Flash Point: Not flammable
Viscosity: Moderate, due to Ficoll; higher than pure water
Chemical Stability: Stable under recommended storage and handling conditions
Incompatible Materials: Strong acids, strong bases, strong oxidizing agents
Hazardous Decomposition: May release carbon oxides and sodium compounds if heated to decomposition
Polymerization: Product does not undergo hazardous polymerization
Conditions to Avoid: Excessive heat, freezing, contamination, direct sunlight
Acute Toxicity: Expected low toxicity based on ingredients; ingestion of large volumes may cause gastrointestinal irritation
Chronic Toxicity: No evidence of chronic toxicity with normal laboratory use
Skin and Eye Contact: May cause mild irritation with prolonged or repeated direct contact
Inhalation: Unlikely to present an inhalation hazard under normal use
Sensitization: No known sensitizing effects reported
Carcinogenicity: Not listed by IARC, NTP, OSHA, or ACGIH as a carcinogen
Ecotoxicity: Data for sodium diatrizoate suggest low toxicity to aquatic life at expected release amounts from laboratory use
Persistence and Degradability: Product expected to be poorly biodegradable due to synthetic polymer; not persistent at laboratory use levels
Bioaccumulation Potential: Low based on water solubility and lack of significant absorption into tissue
Mobility in Soil: High mobility due to solubility in water; avoid discharge to environment
Other Adverse Effects: Product does not contain substances with known significant environmental hazard at supplied concentrations
Waste Disposal Methods: Dispose of contents and container in accordance with local, regional, national, and international regulations
Additional Information: Avoid release to sewers, surface water, or soil; burn or landfill solid absorbent material in accordance with applicable regulations, rinse used containers before disposal where permitted
Recommendation: Laboratories should use professional hazardous chemical waste management services
UN Number: Not regulated for transport
Proper Shipping Name: Not dangerous goods for land, air, or sea transport
Transport Hazard Class: Not classified as hazardous
Packing Group: Not applicable
Special Precautions for Transport: Protect from extreme temperatures, handle securely to prevent leaks
US TSCA: Listed
European Community (EINECS): Listed components
Other International Regulations: Australia (AICS), Japan (ENCS), and Canada (DSL) inventories list major ingredients
SARA Title III: Not subject to reportable quantities or threshold planning requirements
California Prop 65: Ingredients not listed
Workplace Hazardous Materials Information System (WHMIS): Not controlled
Labelling Requirements: Not required under OSHA Hazard Communication Standard for intended use
