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Chemical Name: Ferrostatin-1
Chemical Formula: C21H22N2O2
Synonyms: Fer-1
Use: Research laboratories focus on Ferrostatin-1 because of its ability to block ferroptosis, a form of cell death involving iron.
Hazard Classification: Most databases flag Ferrostatin-1 as a toxic substance, especially if ingested, inhaled, or introduced to skin and eyes.
Signal Word: Warning
Hazard Statements: Can irritate the respiratory tract, skin, and eyes; acute exposure might cause symptoms similar to organic solvent toxicity; long-term risks have not been fully assessed due to its niche use.
Pictograms: Exclamation mark commonly appears to remind workers about irritation threats.
Main Ingredient: Ferrostatin-1—no major impurities reported when sourced from reputable suppliers.
Chemical Structure: Aromatic hydrocarbon core, with amide and secondary amine functional groups lending solubility in some organic solvents.
CAS Number: 347174-05-4
Inhalation: Move the person to fresh air, watch for breathing difficulties, and consult a physician if symptoms persist.
Skin Contact: Remove contaminated clothing; wash skin thoroughly with soap and water; if redness or rash develops, get medical help.
Eye Contact: Rinse cautiously with water for several minutes; lift eyelids to flush thoroughly; seek attention if irritation lingers.
Ingestion: Rinse mouth, and avoid inducing vomiting; seek immediate medical opinion.
Suitable Extinguishing Media: Use foam, dry chemical, or carbon dioxide; water spray might do more harm since the powder can disperse.
Hazardous Combustion Products: Burning produces irritating and toxic gases—nitrogen oxides, carbon oxides.
Special Equipment: Firefighters wear self-contained breathing apparatus; chemical-protective clothing provides a safer line of defense against runoff and smoke.
Personal Precautions: Don gloves, goggles, and a lab coat; keep dust to a minimum and avoid inhaling particles.
Environmental Precautions: Don’t let substances enter drains; take care to scoop up spills promptly using inert absorbent material.
Cleanup Method: Sweep up and transfer to a suitable container for disposal; ventilate the area thoroughly before allowing regular use again.
Handling: Avoid breathing dust, wear personal protective gear, keep containers tightly sealed, and wash hands after use.
Storage: Keep in a cool, dry, and well-ventilated spot, away from incompatible chemicals such as oxidizers; patience with storage temperatures pays off—most guidelines stick with fridge temperatures, and light-blocking containers preserve stability.
Engineering Controls: Work in a fume hood for bulk transfers, and use local exhaust ventilation for smaller jobs.
Protective Equipment: Gloves, goggles, lab coats, and sometimes respirators for those handling grams or more of the compound; always wash hands after use.
Exposure Limits: No established limits from OSHA or ACGIH, due to lack of industrial-scale use.
Appearance: Pale solid powder, sometimes described as off-white or beige.
Odor: No strong odor reported—typical for small organic molecules.
Solubility: Soluble in DMSO, insoluble in water.
Melting Point: Data limited, reported ranges around 150-155°C.
Boiling Point: Information not available; compound usually used as a solid or dissolved.
Other Properties: Light-sensitive; can degrade if left in open containers at room temperature.
Chemical Stability: Stable under common laboratory conditions when kept cold, dry, and shielded from light.
Reactivity: Avoid contact with oxidizing agents, acids, or bases that could alter its chemical backbone.
Decomposition: Produces hazardous fumes under fire, contributing to health risks for unprotected staff.
Acute Effects: Irritant to skin, eyes, and respiratory tract based on typical aromatic amide behavior; oral toxicity estimates rely on analogous compounds, not specific animal tests.
Chronic Effects: Long-term risks are not documented; with limited industrial use, comprehensive studies are scarce.
Other Risks: Lab workers should avoid unnecessary exposure until clearer toxicity profiles exist after robust animal or clinical studies.
Environmental Impact: Not well studied; related small molecules often show toxicity to aquatic species and persistence in soils if not neutralized.
Mobility: Stays put once absorbed to surfaces—doesn’t leach quickly.
Precaution: Handle as a toxic compound; prevent all forms of environmental contamination, especially into water streams.
Waste Disposal Method: Treat as hazardous lab waste; collect solids and solutions in labeled chemical waste containers for licensed disposal firms.
Do Not: Pour down drains, include with regular trash, or incinerate in office buildings.
Shipping Considerations: Not classified under mainstream hazardous materials codes but always ship with clear labeling; sealed packaging and cool boxes recommended.
Precautions: Avoid shipping with incompatible chemicals or in unventilated vans.
Legal Status: Research-chemicals don’t appear on main hazardous substance lists like TSCA or REACH, yet institutions often require internal registration and oversight.
Workplace Policy: Institutions usually ask for internal authorization before purchase and demand standard lab safety training for anyone handling it.
