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Material Safety Data Sheet for EX-CELL CD CHO Fusion

Identification

Product Name: EX-CELL CD CHO Fusion
Manufacturer: MilliporeSigma, a business of Merck KGaA, Darmstadt, Germany
Product Number: 14365C
Recommended Use: Cell culture medium, research use only
Supplier Contact: 1-800-645-5476 (US), Emergency Response: CHEMTREC 1-800-424-9300
Address: 400 Summit Drive, Burlington, MA 01803, USA

Hazard Identification

Classification: Not classified as hazardous under GHS standards
Signal Word: None
Hazard Statements: No known significant effects or critical hazards
Precautionary Statements: Practice good laboratory hygiene. Avoid inhalation, ingestion, contact with eyes and skin.
Physical Hazard: Non-combustible; does not support fire
Health Hazard: May cause mild skin or eye irritation based on component data
Environmental Hazard: Low risk for acute environmental toxicity at small scales

Composition / Information on Ingredients

Chemical Nature: Chemically-defined, protein-free powder or dry blend for cell cultures
Key Components: Inorganic salts, carbohydrates (glucose, galactose), amino acids, vitamins, trace elements
Contains: No hazardous ingredients above cut-off levels
CAS Numbers: Mixture; component CAS numbers available by request
Form: White to off-white powder
Impurities: No known hazardous impurities

First Aid Measures

Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy; continue rinsing
Skin Contact: Wash with plenty of water and soap; consult a physician if irritation persists
Inhalation: Move to fresh air; seek medical attention if symptoms develop
Ingestion: Rinse mouth, do not induce vomiting, seek medical advice if discomfort occurs
Note for Physicians: Treat symptomatically; no specific antidote known

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, carbon dioxide, foam, or dry chemical.
Unsuitable Extinguishing Media: Direct water jet may scatter dust
Hazardous Combustion Products: Oxides of carbon, nitrogen, and other trace elements expected in fire
Protective Equipment: Self-contained breathing apparatus (SCBA) and full protective gear for fire conditions
Fire Fighting Procedures: Avoid breathing smoke or fumes; move containers from fire area if safe

Accidental Release Measures

Personal Precautions: Use personal protective equipment. Avoid dust generation
Environmental Precautions: Prevent entry into drains and surface waters
Methods for Cleaning Up: Sweep up and place in suitable container for disposal; ventilate area
Reference to Other Sections: See Sections 8 and 13 for exposure controls and disposal

Handling and Storage

Handling: Handle in accordance with good laboratory practices. Avoid spills, dust, inhalation, and contact with eyes and skin.
Storage: Store tightly closed in a cool, dry, well-ventilated place. Keep away from incompatible substances (strong acids and bases, oxidizing agents).
Other Precautions: Only trained personnel should use; store away from food and drink

Exposure Controls and Personal Protection

Engineering Controls: Work in well-ventilated areas, ideally using a laboratory fume hood to minimize exposure
Eye Protection: Chemical safety glasses or goggles
Skin Protection: Lab coat, gloves resistant to chemicals
Respiratory Protection: Dust mask or approved respirator in case of dust generation
Hygiene Measures: Wash hands after handling; avoid eating, drinking, or smoking in work area
Exposure Limits: No occupational exposure limit values specifically established for this product; follow general industry guidelines

Physical and Chemical Properties

Appearance: White to off-white, free-flowing powder
Odor: Odorless or slight
pH (1% solution): 6.8 – 7.4
Melting/Freezing Point: Not established for mixture
Boiling Point: Not applicable
Solubility: Soluble in water
Vapor Pressure: Not applicable
Density: Not determined
Flash Point: Not flammable
Evaporation Rate: Not applicable

Stability and Reactivity

Chemical Stability: Product is stable under recommended storage conditions
Reactivity: No dangerous reactions known
Hazardous Polymerization: Does not occur
Conditions to Avoid: Excessive heat, moisture, and incompatible materials
Incompatible Materials: Strong oxidizers, acids, and bases
Hazardous Decomposition Products: Carbon and nitrogen oxides under fire or extreme conditions

Toxicological Information

Acute Toxicity: No acute toxicity data available for mixture
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Potential Health Effects: Dust may cause slight irritation of respiratory tract, eyes, or skin
Chronic Exposure: Not expected due to nature of components
Carcinogenicity: No components classified as carcinogens by IARC, NTP, OSHA
Reproductive/Developmental Effects: No evidence of reproductive toxicity
Target Organs: No specific target organs identified through current data

Ecological Information

Ecotoxicity: No significant aquatic or soil toxicity expected for small quantities
Environmental Fate: Readily biodegradable ingredients; product disperses in water
Persistence and Degradability: Ingredients generally degrade rapidly in environment
Bioaccumulative Potential: Low potential for bioaccumulation
Mobility in Soil: High mobility, no significant environmental accumulation anticipated
Other Effects: Large releases may temporarily affect aquatic ecosystems due to nutrient load

Disposal Considerations

Waste Treatment Methods: Dispose of according to local, regional, and national regulations
Product Disposal: Small quantities can often be washed down the drain with plenty of water unless local rules prohibit;
Packaging Disposal: Triple-rinse container before disposal, or follow facility protocol for chemical waste
Additional Notes: Users are responsible for safe management of product residues and containers

Transport Information

UN Number: Not regulated for transport
UN Proper Shipping Name: Not classified as dangerous
Transport Hazard Class: Not applicable
Packing Group: Not regulated
Environmental Hazards: Not considered a marine pollutant or environmentally hazardous substance
Transport Precautions: Protect from physical damage and moisture during shipment

Regulatory Information

US TSCA: Exempt as a research and development substance, not listed for commercial products
OSHA: Not classed as hazardous
SARA Section 313: No reportable components
California Proposition 65: Not listed
EU REACH: Manufactured and supplied for R&D; not subject to pre-registration or registration
WHMIS Canada: Not controlled
Other Regulations: Product does not contain substances regulated under major chemical safety acts