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Name: Endoproteinase Lys-C, Sequencing Grade
Common Use: Protein sequencing, proteomic sample preparation, mass spectrometry workflows
Physical State: Lyophilized powder or frozen solution
Color: White to off-white
Odor: Odorless
Lab Category: Research and laboratory use only, not for human or veterinary applications
GHS Classification: Not classified as hazardous in its lyophilized or solution form under typical lab concentrations
Main Risks: Allergic reactions in sensitive individuals, respiratory or skin sensitization possible if inhaled or touched
Physical Hazards: Dust may irritate eyes or respiratory tract
Health Hazards: No chronic health effects known; protein materials can trigger asthma or rhinitis in rare cases
Environmental Hazards: No acute environmental impact apparent in standard lab use
Component: Endoproteinase Lys-C (Serine protease from Lysobacter enzymogenes)
Purity: Typically >95% as supplied for sequencing-grade use
Stabilizers or Buffers: Trace ammonium bicarbonate or Tris buffers; sugar or salt stabilizers may be present at low levels
Formula: Protein, large polypeptide chain (not a small molecule or hazardous inorganic)
Inhalation: Move affected person to fresh air; seek medical help if symptoms such as difficulty breathing appear
Skin Contact: Wash off with soap and water; remove contaminated clothing; obtain medical advice if irritation develops
Eye Contact: Rinse immediately with water for at least 15 minutes; contact an ophthalmologist if irritation persists
Ingestion: Rinse mouth with water; get medical attention if symptoms arise
Suitable Extinguishing Media: Water spray, CO2, dry chemical, foam
Specific Hazards: Protein powders can burn; combustion releases carbon oxides, nitrogen oxides
Protective Equipment: Standard firefighting gear, avoid inhalation of smoke or dust
Special Procedures: Use caution to avoid dust generation; proteins may denature and release irritating fumes
Personal Precautions: Avoid dust inhalation, use gloves and mask if powder is present
Spill Cleanup: Absorb spills with wet paper towels, avoid dry sweeping
Disposal: Place material in sealed bag, dispose with biological waste according to local rules
Ventilation: Work in well-ventilated areas or chemical fume hood, especially with powders
Safe Handling: Minimize dust generation, use in designated lab spaces
Personal Hygiene: Avoid touching eyes and mouth, wash hands after handling
Storage Requirements: Store at −20°C or below for enzyme stability
Container: Keep in tightly sealed original packaging or pre-aliquoted vials
Engineering Controls: Use inside fume hood or biosafety cabinet if handling large amounts
Respiratory Protection: Not required for routine handling, but use particle mask if risk of aerosol formation
Skin Protection: Disposable lab gloves, nitrile preferred
Eye Protection: Lab safety glasses
General Protection: Standard lab coats or disposable aprons
Workplace Monitoring: Not usually necessary; pay attention to potential for allergy in frequent users
Appearance: White to off-white lyophilized solid or clear solution
Solubility in Water: Readily soluble at working concentrations (10–50 mM buffer solutions)
pH: Neutral to slightly basic in aqueous solution
Odor: Odorless
Melting Point: Not applicable for proteins (denaturation rather than classical melting or boiling)
Flammability: Low; protein powders can burn but do not present major fire risk in small quantities
Vapor Pressure: Not volatile, negligible vapor pressure
Partition Coefficient: Not applicable for large biological macromolecules
Stability: Stable at low temperatures (−20°C or below); loss of activity above room temperature over time
Conditions to Avoid: High temperatures, repeated freeze-thaw cycles, strong acids or reducing agents
Incompatible Materials: Strong oxidizers, organic solvents, heavy metals
Decomposition Products: Peptides, small organics, nitrous and carbon oxides if burned
Reactivity: No dangerous polymerization or violent reactivity under standard lab use
Routes of Exposure: Inhalation, skin, and eye contact possible during handling
Acute Effects: Mild irritation to eyes or skin may occur; allergy or sensitization in rare cases
Chronic Effects: No evidence for mutagenic, teratogenic, or carcinogenic effects in scientific literature
Sensitization: Possible for proteins with repeated exposures, as with many enzymes
LD50 or Toxicity Data: No established LD50 in mammals; not acutely toxic by oral or dermal routes at laboratory concentrations
Mobility: Readily degraded in biological environments; unlikely to persist
Persistence and Degradability: Enzymes degrade by hydrolysis, microbial activity
Bioaccumulation: Not expected to bioaccumulate
Aquatic Toxicity: No evidence of toxicity to aquatic organisms at typical lab scale disposal levels
Other Environmental Hazards: Minimal impact expected under normal laboratory disposal practices
Methods: Dispose as biological waste or non-hazardous chemical waste in accordance with institutional and municipal guidelines
Precautions: Avoid release of powder to drains or the open environment; cleanup with damp disposable wipes
Container Disposal: Decontaminate and discard according to laboratory protocols (autoclaving if required)
UN Number: Not regulated as hazardous for transport by ground, air, or sea
Packing Group: N/A for research quantities
Special Precautions: Ship with coolant or dry ice if stability requires cold chain, label as non-hazardous biological material
OSHA Status: Not classified as hazardous in its purified form
GHS Labeling: No pictogram or signal word required for laboratory use; observe standard precautions
Other Regulatory Lists: Not listed by IARC, NTP, or EPA as a carcinogen or environmental threat
User Responsibility: Research labs and users must assess risks, implement best practices for handling all biological materials, and keep up to date with local regulations as part of ongoing lab safety culture
