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Product Name: COMPLETE™ EDTA-Free Protease Inhibitor Cocktail
Product Code: 11836170001
Supplier: Roche Diagnostics
Recommended Use: Laboratory reagent, protease inhibition in protein extraction and purification
Emergency Contact: Local poison control center or Roche Diagnostics emergency line
Email: techsupport@roche.com
Address: Roche Diagnostics GmbH, 68298 Mannheim, Germany
Telephone: +49 621 759 0
Classification: Non-hazardous according to Regulation (EC) No 1272/2008; not classified as dangerous
Physical Hazards: None known; solid tablets pose minor physical risk
Health Hazards: May cause mild irritation to eyes and skin
Environmental Hazards: Not classified as hazardous to environment
Signal Word: Not required
Pictogram: Not applicable
Hazard Statement: Not a hazardous mixture
Precautionary Statement: Avoid direct contact; wash hands after use
Benzamidine HCl: CAS 7164-07-0. 0.5–1.0%. Serine protease inhibitor.
Aprotinin: CAS 9087-70-1. < 1%. Protease inhibitor; risk of allergenic reaction.
Leupeptin: CAS 103476-89-7. < 1%. Cysteine and serine protease inhibitor.
Pepstatin A: CAS 26305-03-3. < 1%. Aspartic protease inhibitor.
AEBSF (Pefabloc SC): CAS 30827-99-7. < 1%. Serine protease inhibitor.
Bestatin: CAS 51938-32-0. < 1%. Aminopeptidase inhibitor.
Soluble Fillers: Mannitol, microcrystalline cellulose. Inert, > 98%.
Note: No hazardous components above regulatory thresholds.
General: Remove contaminated clothing. Seek medical attention if symptoms persist.
Inhalation: Move exposed person to fresh air. Monitor breathing. Get medical help for respiratory symptoms.
Skin Contact: Rinse with plenty of water. Use soap to remove residues. Seek medical attention for irritation.
Eye Contact: Immediately rinse eyes with water for at least 15 minutes. Lift eyelids to remove particles.
Ingestion: Rinse mouth. Do not force vomiting. Seek medical attention if discomfort develops.
Most Important Symptoms: Mild skin/eye irritation, respiratory irritation in sensitive individuals.
Advice for Medics: Treat symptomatically. No specific antidote.
Flammability: Not classified as flammable.
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, foam.
Unsuitable Methods: Strong water jet can scatter product.
Special Hazards: In a fire, decomposition may yield carbon oxides, nitrogen oxides.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear.
General Advice: Contain fire-fighting water. Prevent from entering watercourses or drains.
Explosion Risk: No known risk under normal use.
Personal Precautions: Wear suitable gloves, lab coat, protective eyewear. Avoid dust formation.
Environmental Precautions: Prevent spill from entering sewers or rivers. Notify authorities if product contaminates environment.
Containment: Pick up tablets mechanically. For powder, sweep up without creating dust.
Cleaning: Wipe affected surfaces with damp cloth. Ventilate area.
Disposal: Dispose of collected material in accordance with regulations.
Decontamination: Wash contacted area with soap and water.
Accidental Exposure Procedures: Provide fresh air, seek medical attention where necessary.
Handling: Use with adequate ventilation. Avoid contact with eyes and skin. Do not eat, drink, or smoke while handling.
Hygiene: Wash hands thoroughly after use.
Storage Conditions: Store at 2–8°C (refrigerated). Keep container tightly closed and dry.
Storage Class: General chemical storage. Segregate from food and feeding stuffs.
Incompatibilities: Strong acids and oxidizing agents.
Specific Use(s): For laboratory or research purposes only.
Packaging Materials: Polyethylene bottle, moisture-resistant container.
Occupational Limits: Not established for these ingredients.
Engineering Controls: Use in a fume hood or ventilated area.
Respiratory Protection: Dust mask for large quantities or dust-producing activities.
Hand Protection: Nitrile or latex gloves; wash hands after removal.
Eye Protection: Safety glasses with side-shields.
Skin Protection: Lab coat or protective clothing.
Hygiene Measures: Means for eye washing and safety showers should be accessible.
Environmental Controls: Prevent material from reaching ground water or sewer.
Form: Solid, tablet.
Color: White or off-white.
Odor: Odorless.
pH: Not applicable in solid form; pH in solution 6–8.
Melting Point: Not determined.
Solubility: Soluble in water.
Boiling Point: Not applicable.
Vapor Pressure: Not relevant.
Density: Not measured.
Partition Coefficient (n-octanol/water): Not available.
Decomposition Temperature: Not measured.
Chemical Stability: Stable under recommended storage conditions.
Reactivity: Not reactive with normal laboratory materials.
Possibility of Hazardous Reactions: No hazardous reactions known.
Conditions to Avoid: Heat, moisture, direct sunlight.
Materials to Avoid: Strong oxidizers, strong acids.
Hazardous Decomposition: Carbon and nitrogen oxides in case of fire or decomposition.
Polymerization: Will not occur.
Acute Toxicity: No acute toxicity expected based on ingredient concentration.
Skin Corrosion/Irritation: May cause mild irritation in sensitive individuals.
Serious Eye Damage/Irritation: May cause mild transient irritation.
Sensitization: Aprotinin may trigger allergic reactions in sensitized persons.
Mutagenicity: Not expected based on available data.
Carcinogenicity: Not classified as carcinogenic.
Reproductive Toxicity: No ingredients known to have reproductive toxicity.
Long-Term Effects: Not expected from intended use; observe lab safety protocols.
Inhalation: May cause minor respiratory discomfort if dust forms.
Ecotoxicity: No data suggesting significant environmental hazard at use concentration.
Persistence and Degradability: Expected to be biodegradable.
Bioaccumulative Potential: Low; no evidence of bioaccumulation.
Mobility in Soil: Soluble in water; potential for leaching if spilled.
Other Adverse Effects: Prevent large amounts from entering waterways.
Aquatoxicity: No known toxic effect to aquatic organisms using at proper disposal.
Waste Disposal Methods: Dispose of in accordance with local, state, and federal regulations.
Packaging Disposal: Empty containers should be rinsed and recycled if possible.
Unused Product: May be disposed of as non-hazardous chemical waste.
Precautions: Prevent environmental release in large quantities.
Incineration: Permitted in equipped facilities.
Do Not: Dispose into normal household waste or sewer.
UN Number: Not regulated.
UN Proper Shipping Name: Not classified as dangerous for transport.
Transport Hazard Class: None.
Packing Group: Not applicable.
Marine Pollutant: No.
Special Precautions for Users: None required.
Transport in Bulk: Not applicable.
DOT, IATA, IMDG: Not regulated.
Labelling: This product does not require hazardous labeling for supply or use.
TSCA: Listed components comply.
REACH: Exempt from registration as a mixture.
OSHA Regulatory Status: Not hazardous.
Canadian WHMIS: Not controlled.
EU Regulations: Not classified under Regulation (EC) No 1272/2008.
SARA Title III Sections 302/311/312: Not a hazardous chemical.
Australia AICS: All components listed.
Japan ENCS: All components listed.
Restrictions: For laboratory use only; not for drug, household, or other uses.
