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Product Name: Dulbecco's Modified Eagle's Medium
Common Names: DMEM, Eagle's Medium
Recommended Use: Cell culture, laboratory research
Manufacturer: Refer to specific supplier
Contact Information: Emergency telephone and company details on product label
Synonyms: High-glucose DMEM, Low-glucose DMEM
Chemical Formula: Not applicable (mixture)
CAS Numbers: Component ingredients have individual CAS numbers
GHS Classification: Not classified as hazardous under GHS for most formulations
Routes of Exposure: Inhalation, skin, eyes, ingestion
Health Hazards: Minor irritation possible on contact with eyes or skin, ingestion may cause mild gastrointestinal discomfort
Environmental Hazards: Components generally show limited impact, still avoid release into waterways
Label Elements: No pictograms for standard DMEM
Signal Word: No signal word required for most DMEM
Precautionary Statements: Safe handling practices recommended; avoid contact and inhalation of dust
Major Ingredients: D-Glucose (typically 1 or 4.5 g/L), Sodium chloride, Potassium chloride, Calcium chloride dihydrate, Magnesium sulfate, Sodium bicarbonate
Other Components: Amino acids (L-Arginine, L-Glutamine, L-Histidine, etc.), Vitamins (Choline chloride, Folic acid, Nicotinamide, Riboflavin, etc.), Phenol red (pH indicator, optional)
Water: Ultrapure or deionized
CAS Numbers: Provided on specific product sheets; for phenol red - 143-74-8, for D-Glucose - 50-99-7
Concentration Range: Each ingredient present in millimolar to micromolar levels depending on formula
Inhalation: Move to fresh air promptly, seek medical advice if symptoms persist
Skin Contact: Wash with soap and plenty of water, remove contaminated clothing
Eye Contact: Flush eyes with running water for several minutes; seek medical attention if irritation develops
Ingestion: Rinse mouth with water, do not induce vomiting, get medical advice if large amount swallowed or symptoms develop
Medical Attention: No known acute hazards, symptomatic care as needed
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical, foam
Unsuitable Media: None known for DMEM
Specific Hazards: Material itself will not burn, but containers can burst in a fire due to steam buildup
Protective Equipment: Self-contained breathing apparatus, protective clothing
Firefighting Instructions: Prevent run-off from entering drains or watercourses, use normal firefighting procedures
Personal Precautions: Wear gloves, eye protection, and lab coat, avoid dust or aerosol formation
Environmental Precautions: Prevent entry to sewers or waterways
Cleanup Methods: Sweep up or soak with inert material, place in labeled waste container for disposal, ventilate area, wash spill site after handling
Handling: Use in well-ventilated area, avoid inhaling dust or aerosol, practice good laboratory hygiene
Storage: Keep in tightly closed original container, store at refrigerated temperature (2-8°C) or as specified, protect from light
Incompatible Materials: Strong oxidizing agents, acids or bases may degrade some components
Special Precautions: Keep away from sources of contamination and food/drinks, avoid freezing unless specified
Exposure Limits: Not set for DMEM, follow general laboratory guidelines
Engineering Controls: Use biological safety cabinet for cell culture work, maintain adequate ventilation
Personal Protective Equipment (PPE): Wear lab coat, safety goggles, nitrile or latex gloves; change gloves frequently
Hygiene Measures: Wash hands thoroughly after handling, avoid eating or drinking in work area
Appearance: Lyophilized (powder) or liquid form, typically red-orange if phenol red included
Odor: Slight, not strong or unpleasant
pH: 7.0-7.4 in solution
Melting/Freezing Point: Not applicable as a mixture
Boiling Point: Not determined
Flash Point: Not determined; not considered flammable
Solubility: Soluble in water
Density: Similar to water solution when prepared
Other Data: Stable under recommended conditions
Chemical Stability: Stable under normal storage and handling
Reactivity: No significant reactivity known
Decomposition Products: May yield oxides of carbon, nitrogen, and sulfur during thermal decomposition
Conditions to Avoid: Excessive heat, contact with incompatible substances
Polymerization: Will not occur
Acute Toxicity: Not acutely toxic based on available data
Skin: May cause mild irritation for sensitive individuals
Eyes: Direct contact might irritate
Ingestion: Generally not hazardous in small quantities
Chronic Effects: No studies report chronic hazards for DMEM as a mixture
Sensitization: No data available
Carcinogenicity: No ingredients listed by NTP, IARC, or OSHA as carcinogens
Ecotoxicity: Most constituents have low potential for bioaccumulation or aquatic toxicity
Mobility: High in water due to solubility
Persistence/Degradability: Components likely to degrade naturally
Bioaccumulation: Not expected
Other Effects: Avoid large releases into environment to minimize risk
Waste Treatment Methods: Dispose as non-hazardous laboratory waste unless contaminated
Disposal Containers: Place waste in appropriately labeled containers
Environmental Precautions: Do not dispose of via drains or into the environment
Regulations: Follow institutional, local and federal guidelines for chemical waste
UN Number: Not regulated for transport
Proper Shipping Name: Not classified as dangerous
Transport Hazard Class: None
Packing Group: Not applicable
Special Precautions: Protect from physical damage during shipment
DOT/IATA/IMDG: Not a hazardous material for transport
TSCA Status: Ingredients listed or exempt
REACH Status: Most ingredients covered
Chemical Inventories: Components typically listed
Other Regulatory Data: Not regulated as hazardous per OSHA, GHS, or most international guidelines
Labeling Recommendations: Follow laboratory code of practice and local procedures
