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Product Name: DL-Dithiothreitol
Other Names: Cleland’s Reagent, DTT
Chemical Formula: C4H10O2S2
CAS Number: 3483-12-3
Relevant Use: Reducing agent, laboratory reagent, research chemical
Supplier Details: Manufacturer name, address, and emergency contact phone number
Recommended Restrictions: For laboratory use only, not for drug, household, or other uses
GHS Classification: Acute toxicity (oral, dermal, inhalation), Eye irritation, Skin sensitization
GHS Pictograms: Exclamation mark, Health hazard
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes serious eye irritation, may cause allergic skin reaction, potentially harmful if inhaled
Precautionary Statements: Avoid breathing dust or vapors, wear protective gloves and eye protection, wash hands thoroughly after handling, if on skin or eyes: rinse cautiously with water
Target Organs: Skin, Eyes, Respiratory System
NFPA Rating: Health: 2; Flammability: 1; Reactivity: 1
Chemical Name: DL-Dithiothreitol
Synonyms: DTT, Cleland's Reagent
CAS Number: 3483-12-3
Concentration: 98-100% (pure substance)
Molecular Weight: 154.25 g/mol
Impurities or Stabilizing Additives: No significant impurities of concern as per manufacturer data
General Information: Consult a physician, show contents of MSDS to medical personnel
If Inhaled: Move to fresh air, monitor breathing, call a physician if symptoms develop
In Case of Skin Contact: Remove contaminated clothing, wash skin thoroughly with plenty of water and soap
If in Eyes: Rinse cautiously with water for several minutes, remove contact lenses if present, seek medical attention if irritation persists
If Swallowed: Rinse mouth with water, do not induce vomiting, seek immediate medical attention
Most Important Symptoms and Effects: Irritation, allergic reactions, respiratory discomfort, gastrointestinal effects
Advice for Medical Personnel: Symptomatic treatment, keep patient under observation, monitor for delayed effects
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical powder, or carbon dioxide
Unsuitable Extinguishing Media: No information on specific products to avoid, avoid heavy water jets to prevent chemical spreading
Specific Hazards Arising from Chemical: May release toxic fumes (sulfur oxides, carbon oxides) during combustion
Protective Equipment for Firefighters: Wear self-contained breathing apparatus and full protective gear
Special Fire-Fighting Procedures: Avoid runoff into sewers and waterways, stay upwind of fire
Thermal Decomposition Products: Sulfur dioxide, hydrogen sulfide, carbon monoxide, carbon dioxide
Personal Precautions: Evacuate unnecessary personnel, use suitable protective equipment (gloves, goggles, appropriate respiratory protection), ventilate area
Environmental Precautions: Prevent further leakage or spillage, prevent entry into waterways, soil, and drains, report spills to local authorities if required
Methods for Cleanup: Scoop up material using non-sparking tools, place in dry, closed containers for disposal, clean area with water and detergent avoiding dust formation
Reference to Other Sections: Wear personal protective equipment as described in Section 8; dispose waste as detailed in Section 13
Handling: Keep container tightly closed, work under a fume hood or with adequate ventilation, avoid breathing dust, avoid skin and eye contact, use proper PPE
Hygiene Measures: No eating or drinking in work area, wash hands before breaks and after working, handle with care to prevent spills
Storage: Store in cool, dry, well-ventilated space away from direct sunlight and moisture
Recommended Storage Temperature: 2-8°C (refrigerated), protect from air exposure
Incompatible Materials: Strong oxidizing agents, acids, heavy metal salts
Packing Material: Use non-reactive, tightly sealed containers
Engineering Controls: Use process enclosures, local exhaust, or other engineering controls to keep airborne concentrations below recommended exposure limits
Exposure Limits: No specific occupational exposure limits established for DTT, maintain low exposure by good lab practices
Eye Protection: Safety goggles with side shields, face shield if splash risk
Skin Protection: Nitrile or neoprene gloves, lab coat, long sleeves
Respiratory Protection: Approved dust mask if dust formation, use respirator in poorly ventilated areas
Environmental Controls: Prevent release into the environment, use chemical fume hood, proper containment methods
Appearance: White or off-white crystalline powder
Odor: Faint sulfurous or skunky odor
Odor Threshold: Not available
pH: About 6.5 (10 g/L in water at 20°C)
Melting Point/Freezing Point: 40-44°C
Boiling Point/Range: Not determined
Flash Point: >100°C (estimated)
Evaporation Rate: Not applicable (solid)
Flammability: Low fire hazard
Explosion Limits: Not applicable (solid)
Vapor Pressure: Negligible at room temperature
Vapor Density: Not applicable
Relative Density:** 1.2-1.3 g/cm³
Solubility in Water: 100 g/L (highly soluble)
Partition Coefficient (log Pow): -2.1 (very hydrophilic)
Auto-Ignition Temperature:** Not determined
Decomposition Temperature: Not reported
Viscosity: Not applicable
Chemical Stability: Stable in closed containers at recommended storage conditions
Possibility of Hazardous Reactions: May react with oxidizing agents, acids, and certain metal ions to produce heat or toxic gases
Conditions to Avoid: Air exposure, moisture, heat, direct sunlight
Incompatible Materials: Strong oxidizers, acids, heavy metals
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, sulfur dioxide, hydrogen sulfide
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity (oral): LD50 (rat) 400 mg/kg
Skin Corrosion/Irritation: Causes mild to moderate irritation on contact
Serious Eye Damage/Eye Irritation: Causes severe eye irritation
Respiratory/Skin Sensitization: May cause allergic skin reactions
Chronic Effects: No adequate data for reproductive toxicity or carcinogenicity, repeat exposure may sensitize skin and respiratory tract
Symptoms of Exposure: Irritation, sensitization, discomfort, burning sensation, nausea
Aspiration Hazard: Not classified
Ecotoxicity: Harmful to aquatic life, data suggest low to moderate toxicity in aquatic organisms
Persistence and Degradability: Readily biodegradable, decomposes in the environment with exposure to air and light
Bioaccumulative Potential: Low potential due to high water solubility and low log Pow
Mobility in Soil: Very mobile in aqueous environments, may leach into groundwater
Results of PBT and vPvB assessment: Does not meet criteria for Persistent, Bioaccumulative, Toxic; not very Persistent or very Bioaccumulative
Other Adverse Effects: May alter redox balance in aquatic environments if released in quantity
Disposal Methods: Dispose as hazardous chemical waste in accordance with local, regional, national, and international regulations
Disposal of Contaminated Packaging: Rinse containers, dispose following guidelines, do not reuse for any other chemicals
Special Precautions: Do not release into sewers or surface water, do not landfill untreated material, consult licensed waste disposal contractor
UN Number: Not regulated for transport
Proper Shipping Name: Dithiothreitol, non-hazardous for air, ground, and sea transport
Transport Hazard Class: Not classified
Packing Group: Not assigned
Environmental Hazards: Not a marine pollutant under IMDG
Special Precautions for User: Avoid contact with incompatible materials, use secure containers
Transport in Bulk: Not applicable, not transported in bulk quantities
OSHA: Not listed as hazardous under OSHA 29 CFR 1910.1200
TSCA (USA): Listed in US Toxic Substances Control Act inventory
REACH (EU): Registered as a substance; observe relevant requirements for handling
SARA Title III: Not classified as an extremely hazardous substance
California Proposition 65: Not listed
WHMIS (Canada): Not classified as a controlled product
Other Regulations: Consult local, national, and international standards for safe handling; user is responsible for regulatory compliance
