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Product Name: Discovery HS C18 HPLC Column
Chemical Nature: High purity silica coated with octadecylsilyl (C18) groups, stainless steel casing
Main Use: Liquid chromatography separation for research, chemical analysis, pharmaceutical studies
Appearance: Stainless steel column with packed white silica material; does not emit vapor or odor during use
Physical Risks: Dropping a column causes injury, steel hardware can cause lacerations
Chemical Hazards: Packed bed contains silica, which poses no inhalation hazard unless opened or crushed; alkylsilane surface is chemically inert
Target Organs: None in normal use; direct inhalation or ingestion of packing material may affect respiratory and digestive systems
Risk in Use: Main danger comes from solvents run through the column, not the column material itself; spilled eluents pose risk
Silica Gel: Typically 60 Å pore size, 4-6 μm particles, more than 90 percent of packed bed
C18 Bonded Phase: Surface modification with octadecylsilane
Casing: 316 stainless steel; machined precision fittings
Binding Agents: No additional binding agents or polymeric supports in common C18 columns
Inhalation: Accidental inhalation arises only from broken or spilled packing; move to fresh air, seek medical review for persistent symptoms
Skin Contact: Wash with water and soap after contact with packing powder; steel casing can cause cuts, so disinfect minor wounds
Eye Exposure: Flush eyes with water for at least 15 minutes if silica dust enters
Ingestion: Packing material is not intended for human consumption; medical advice should be sought if significant amounts swallowed
Fire Risk: C18 column material itself is not flammable; stainless steel withstands heat, packing will not ignite
Combustion Products: Only extreme heat could char packing and create silicon oxides
Extinguishing Media: Carbon dioxide, foam, dry chemical for laboratory fires; water spray for steel casing heat absorption
Special PPE: Standard lab fire safety equipment suffices; dangerous smoke comes from solvents or mobile phases used with column, not the column itself
Spill Response: Dropped or crushed column releases dry silica powder; sweep up with minimal dust generation
Personal Protection: Wear gloves and masks during cleanup, especially if powder is airborne
Environmental Precautions: Avoid washing large quantities down the drain; small routine cleaning has minimal impact
Handling: Handle with dry hands to prevent corrosion or contamination; avoid striking or dropping to protect fittings and bed
Storage: Keep columns capped in original boxes; store away from highly acidic or basic fumes, high heat, and laboratory solvents
Compatibility: Protect from strong acids, bases, and halogens; misuse destroys stationary phase properties and shortens column lifetime
Work Controls: Use in well-ventilated areas; work in fume hood when changing mobile phases
Personal Protective Equipment: Safety glasses, lab coat, gloves during unpacking or cleaning up spilled packing
Engineering Controls: Waste lines secured to solvent containers; absorbent pads under column connections to catch solvent drips
Appearance: Steel tube with fine white particles inside
Odor: None
Melting Point: Stainless steel casing withstands high temperatures; silica remains stable until extreme heat
Solubility: Packing material is insoluble in water, common organic solvents
Reactivity: Chemically stable under normal laboratory conditions; reacts only with very strong acids or bases
Chemical Stability: Stable over long periods unless exposed to harsh chemicals
Reactivity: Degrades rapidly in concentrated hydrofluoric acid or strong alkali
Decomposition: Generates silicon dioxide dust, minor organic byproducts if overheated or burned
Inhalation Risk: Inhalation of silica dust can irritate respiratory tract and mucous membranes; chronic inhalation risk arises from repeated, long-term exposure to fine powder
Skin Contact: Causes irritation for sensitive individuals; not a sensitizer
Eye Contact: Causes mechanical irritation
Ingestion: Not acutely toxic, yet not digestible and not intended for consumption
Environmental Release: Minor spills have negligible environmental impact; does not bioaccumulate
Aquatic Toxicity: Silica is naturally occurring and inert, so harmful effects in surface water are unlikely; organic ligands degrade slowly
Persistence: Stainless steel and silica are persistent, rarely dispersed in significant concentrations from standard use
Disposal for Full Columns: Treat as non-hazardous laboratory waste unless heavily contaminated with hazardous solvents
Disposal for Used Packing: Contaminated silica follows local chemical waste disposal requirements
Containment: Secure in sealed bags or containers to prevent accidental release
Transport Hazards: Not classified as dangerous goods under common transport regulations
Packing: Column shipped in sealed packaging to prevent breakage; always secure in secondary containment to avoid damage and potential contact with packing material
Legal Shipping Status: Standard carriers can transport columns without hazardous material declarations
Regulation: No special labeling required for pure columns; follow workplace safety laws for chemical products
Lab Practice: Manage according to standard laboratory hygiene and chemical safety rules
Status: No chemical-specific restrictions beyond what applies generally in research labs for handling solids and sharp, heavy hardware
