Material Safety Data Sheet: Dimethylacetamide (DMA)
Identification
Product Name: N,N-Dimethylacetamide
Chemical Formula: C4H9NO
Synonyms: DMAc, DMAC
CAS Number: 127-19-5
Recommended Use: Solvent in polymers, pharmaceuticals, fibers, coatings
Manufacturer Information: Company name, address, emergency telephone, and supplier details
Emergency Contact: Regional Poison Control or environmental health and safety numbers
Hazard Identification
Hazard Class: Flammable liquid, Harmful if inhaled or swallowed, Causes serious eye irritation, May cause damage to organs through prolonged exposure, Suspected of damaging fertility or unborn child
Hazard Statements: H319: Causes serious eye irritation; H312: Harmful in contact with skin; H226: Flammable liquid and vapor; H360D: May damage the unborn child; H335: May cause respiratory irritation
Precautionary Statements: Avoid breathing mist or vapor, Keep container tightly closed, Wear protective gloves and eye protection, Wash hands thoroughly after handling, Use only outdoors or in a well-ventilated area
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Composition / Information on Ingredients
Chemical Name: N,N-Dimethylacetamide
Concentration: ≥ 99%
Impurities: Trace-level by-products depending on manufacturing source
First Aid Measures
Inhalation: Move to fresh air immediately; keep victim warm and at rest; seek medical advice if symptoms like dizziness, headache, or respiratory discomfort occur
Skin Contact: Remove contaminated clothing; wash affected skin with plenty of water and soap; get medical attention if irritation develops
Eye Contact: Rinse cautiously with water for at least 15 minutes, keeping eyelids open; remove contact lenses if present and easy to do; seek medical help right away
Ingestion: Rinse mouth - do not induce vomiting; drink small amounts of water; seek medical assistance without delay; never give anything by mouth to an unconscious person
Most Important Symptoms: Irritation, drowsiness, headache, nausea, possible liver or reproductive effects with prolonged or repeated exposure
Notes for Physicians: Treat symptomatically and monitor liver and kidney function
Fire-Fighting Measures
Suitable Extinguishing Media: Carbon dioxide, dry chemical, foam, water spray or fog
Hazardous Combustion Products: Emits toxic fumes of oxides of nitrogen and carbon on combustion
Firefighting Procedures: Evacuate area; cool exposed containers with water spray; wear full protective clothing including self-contained breathing apparatus
Special Hazards: Vapors may form explosive mixtures with air; fire may produce dense, irritating, toxic smoke
Accidental Release Measures
Personal Precautions: Evacuate unnecessary personnel; ventilate area; avoid breathing vapor; wear full PPE including gloves, goggles, and respirator
Environmental Precautions: Prevent further leakage if safe to do; do not allow product to reach sewers, surface water, or groundwater
Methods for Containment: Contain spillage using inert absorbent such as sand, vermiculite, or diatomaceous earth
Methods for Cleanup: Collect absorbed material in suitable sealed containers; clean spill area thoroughly with water after all material picked up
Handling and Storage
Handling: Avoid inhalation or skin contact; use only with adequate ventilation; keep away from heat sources and ignition points; use spark-proof tools and explosion-proof equipment; never smoke near product
Storage: Store in tightly closed, properly labeled containers in a cool, dry, well-ventilated place; avoid storing close to oxidizing agents, acids, bases, or halogens; protect from sunlight and incompatible substances
Storage Temperature: Recommended below 25°C to minimize decomposition
Engineering Controls: Local exhaust ventilation, chemical fume hood if possible, or use outdoors
Personal Protective Equipment: Chemical goggles or face shield, chemical resistant gloves (nitrile or butyl rubber), flame-retardant lab coat or apron, suitable respiratory protection if engineering controls insufficient
Hygiene Measures: Remove and wash contaminated clothing; wash hands before eating, drinking, or using restroom after handling
Monitoring: Regular environmental and personal monitoring in workplace may be required for compliance
Physical and Chemical Properties
Appearance: Colorless to slightly yellow liquid
Odor: Slight, amine-like
Odor Threshold: Nearly 100 ppm
pH: Not applicable (neutral liquid)
Melting Point: -20°C
Boiling Point: 164°C
Flash Point: 65°C (closed cup)
Evaporation Rate: Slower than ether
Flammability: Flammable liquid
Upper/Lower Flammability Limits: 1.8%–11.5% (by volume in air)
Vapor Pressure: 2.2 mmHg at 20°C
Vapor Density: 2.5 (air = 1)
Relative Density: 0.94 g/cm³ at 20°C
Solubility: Miscible with water, ethanol, most organic solvents
Partition Coefficient (log Kow): -0.77
Autoignition Temperature: 355°C
Decomposition Temperature: Above 185°C
Viscosity: About 1.0 mPa.s at 25°C
Stability and Reactivity
Chemical Stability: Stable under recommended handling and storage conditions
Short-term Effects: Irritation to eyes, skin, and respiratory tract, headache, nausea, dizziness, drowsiness
Long-term Effects: Prolonged or repeated exposure may cause liver damage, possible effects on reproductive organs, central nervous system depression, impaired fertility
Carcinogenicity: Not classified as carcinogen by IARC, NTP, ACGIH, or OSHA
Reproductive Toxicity: Studies report possible fetal toxicity in laboratory animals (harm to unborn child suspected)
Other Information: Not considered a sensitizer or to have mutagenic effects based on available studies
Ecological Information
Ecotoxicity: Harmful to aquatic life in cases of large spills; fish LC50 (96 h): 982 mg/l (Leuciscus idus), Daphnia EC50 (48 h): 1120 mg/l
Persistence and Degradability: Biodegradable under aerobic conditions, does not accumulate in the environment
Bioaccumulation: Low potential; low log Kow value
Mobility in Soil: High, due to full miscibility with water, can reach groundwater quickly in event of a spill
Other Adverse Effects: No data on ozone depletion or other global concerns, avoid uncontrolled release to surface water and sewage
Disposal Considerations
Waste Disposal: Dispose of at licensed chemical waste disposal facility in accordance with national and local environmental regulations
Container Disposal: Triple rinse empty containers, remove labels, dispose properly as hazardous chemical containers
Precautions: Do not wash down drain or release to environment; avoid open burning
Transport Information
UN Number: UN 2261
Proper Shipping Name: N,N-Dimethylacetamide
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Marine Pollutant: Not designated as such
Special Precautions for Transport: Keep away from incompatible substances; store in upright containers; secure during shipping; check local and international regulations on chemical transport
Regulatory Information
TSCA Status: Listed in the US Toxic Substances Control Act Inventory
Regulatory Listings: Listed on EINECS, REACH, DSL, and other applicable international chemical inventories
OSHA: Classified as hazardous, requires workplace exposure control
SARA Title III: Not a listed extremely hazardous substance, but subject to reporting requirements under CERCLA
California Proposition 65: Listed as a chemical known to cause reproductive toxicity
Labeling Requirements: Comply with GHS and country-specific regulations
WHMIS Classification (Canada): Class B2 Flammable Liquid, Class D2A Very Toxic Material
Other Restrictions: Compliance with national, regional, and local workplace and environmental rules needed for all handling and disposal activities
