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Product Name: Dimethyl Sulfoxide
SYNONYM: Methyl sulfoxide, DMSO
CAS Number: 67-68-5
Use: Solvent in pharmaceutical, chemical and biological applications
Manufacturer/Supplier: Information available on manufacturer’s label
Emergency Contact: Refer to regional emergency services and poison control centers
Classification: Not classified as hazardous under GHS, but may cause skin and eye irritation, can enhance absorption of other chemicals through skin
Signal Word: Warning
Hazard Statements: May cause mild eye and skin irritation; contact with skin can lead to systemic effects; inhalation of mist may irritate respiratory tract
Precautionary Statements: Avoid breathing vapor or mist, wash hands thoroughly after handling, wear protective gloves, eye protection and clothing
Label Elements: Exclamation mark
Hazards Not Otherwise Classified: Increases absorption of toxicants through skin; potential for liver and kidney effects through heavy exposure
Chemical Name: Dimethyl Sulfoxide
Concentration: 99-100%
Molecular Formula: C2H6OS
Molecular Weight: 78.13 g/mol
Impurities: None expected at standard purity
Eye Contact: Rinse with water for several minutes, remove contact lenses if present, seek medical attention if irritation persists
Skin Contact: Wash with soap and water, take off contaminated clothing, medical attention required for irritation or if symptoms persist
Inhalation: Move person to fresh air, support breathing as needed, get medical attention if symptoms occur
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical advice if large amounts swallowed or discomfort arises
Most Important Symptoms: Eye or skin irritation, headache, dizziness from vapor
Advice for First Responders: Use personal protective equipment, avoid contact with substance during care
Suitable Extinguishing Media: Foam, dry chemical, carbon dioxide, water spray
Unsuitable Media: High-pressure water jet may spread liquid
Specific Hazards: Emits toxic fumes under fire conditions (sulfur oxides, carbon oxides)
Protective Equipment: Full protective gear and self-contained breathing apparatus recommended for firefighters
Special Procedures: Move containers away from fire if safe, cool exposed containers with water spray
Personal Precautions: Evacuate area if needed, wear appropriate protective equipment, ventilate area
Environmental Precautions: Prevent runoff to soil, water, or drains
Clean-up Methods: Small spills: absorb with inert material (e.g. sand), place in chemical waste container; large spills: contain with dikes, collect and dispose as hazardous waste
Reference to Other Sections: Use information from sections on handling, exposure and disposal for further guidance
Precautions for Safe Handling: Avoid skin and eye contact, avoid inhaling vapor or mist, use only with adequate ventilation, keep away from strong acids, oxidizers, and heat
Safe Storage Conditions: Store in tightly closed container, cool, dry, well-ventilated area, away from incompatible substances, protect from sunlight
Special Requirements: Use corrosion-resistant containers;
Hygiene Practices: Wash thoroughly after handling, do not eat, drink or smoke during use
Exposure Limits: None established for DMSO; handle with care due to absorption through skin
Engineering Controls: Use chemical fume hood or local exhaust, eye wash stations and safety showers recommended
Personal Protective Equipment: Chemical-resistant gloves (nitrile, neoprene), safety goggles or face shield, suitable laboratory coats or aprons
Respiratory Protection: Use NIOSH-approved respirators where vapor or mist is generated in poorly ventilated area
Work Practices: Avoid contact with skin, eyes, and clothing; remove contaminated clothing immediately
Appearance: Clear, colorless liquid
Odor: Mild, sulfur-like
Melting Point: 18.5°C (65.3°F)
Boiling Point: 189°C (372°F)
Vapor Pressure: 0.55 mmHg at 20°C
Density: 1.100 - 1.104 g/cm³
Solubility in Water: Miscible
pH: 8.0 - 8.5 (10% solution)
Flash Point: 95°C (closed cup)
Auto-Ignition Temperature: 300°C
Partition Coefficient (n-octanol/water): -1.35
Viscosity: 1.99 cP at 20°C
Evaporation Rate: Not rapid
Chemical Stability: Stable under normal uses and storage conditions
Hazardous Reactions: Vigorous reaction with strong oxidizing agents, acyl halides, strong acids; may form explosive mixtures with some chemicals
Conditions to Avoid: Elevated temperatures, sources of ignition
Incompatible Materials: Strong oxidizers, acids, halogenated compounds
Decomposition Products: Sulfur oxides, methyl mercaptan, formaldehyde under combustion
Routes of Exposure: Inhalation, ingestion, dermal and eye contact
Acute Effects: Skin and eye irritation, headaches, nausea, dizziness
Chronic Effects: Prolonged exposure may affect liver, kidneys and blood
LD50 (oral, rat): 14,500 mg/kg
LD50 (dermal, rabbit): 40,000 mg/kg
Mutagenicity: Not mutagenic in standard tests
Carcinogenicity: Not listed as carcinogen by IARC, NTP, OSHA
Sensitization: Not a known sensitizer
Medical Conditions Aggravated: Those with pre-existing skin, liver, or kidney disorders may experience heightened effects
Ecotoxicity: Low acute toxicity to aquatic organisms, but large quantities may pollute waterways
Persistence and Degradability: Readily biodegradable in the environment
Bioaccumulation: Low potential for bioaccumulation
Mobility in Soil: High; moves easily through soil due to water solubility
Other Adverse Effects: Minimal long-term environmental effects in standard use scenarios
Disposal Methods: Dispose of in accordance with local, regional, and national regulations for organic solvents
Contaminated Packaging: Triple rinse and dispose of in line with hazardous waste procedures
Special Instructions: Do not allow to enter drains or watercourses; treat as hazardous chemical waste
Recommended Waste Treatment: Incineration or chemical treatment in approved hazardous waste facility
UN Number: Not classified as hazardous for transport
Transport Hazard Class: Not regulated for land, air or sea transport in most countries
Packing Group: Not applicable
Proper Shipping Name: Dimethyl Sulfoxide
Environmental Hazards: Not considered environmentally hazardous for transport
Special Transport Precautions: Secure containers, prevent leaks; follow general chemical transport safety
OSHA: Not classified as hazardous, included on TSCA Inventory
EPA: Not a hazardous air pollutant, not subject to SARA Title III
REACH (EU): Registered; not subject to authorisation or restriction
WHMIS (Canada): Not controlled product
Other Regulations: Listed on most national chemical inventories; use workplace controls and labelling systems required for handling chemicals
Local Requirements: Users should consult region-specific regulations for additional details
