© 2026 Nanjing Finechem Holdings Co., Ltd,
All Right Reserved
Chemical Name: Dimethyl Acetylenedicarboxylate
CAS Number: 762-42-5
Common Synonyms: DMAD, Dimethyl ethyne-1,2-dicarboxylate
Molecular Formula: C6H6O4
Appearance and Odor: This compound comes as a clear to pale yellow liquid, with a sharp, unpleasant odor.
Hazard Classifications: Irritant to eyes, skin, and respiratory tract; potential harmful effects on the central nervous system
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation; may be harmful if swallowed, inhaled, or absorbed through skin
Precautionary Statements: Avoid breathing mist, vapors, or spray; wash exposed skin thoroughly after handling; wear protective gear
Main Ingredient: Dimethyl Acetylenedicarboxylate (~98-100%)
Impurities: Small residues of related esters or solvents may be present, but most samples focus on high purity levels for laboratory use.
Inhalation: Bring affected person to fresh air and keep at rest, seek medical attention for difficulty breathing
Skin Contact: Remove contaminated clothing, wash thoroughly with soap and plenty of water
Eye Contact: Rinse with running water for at least 15 minutes, keep eyes wide open to wash fully
Ingestion: Rinse mouth with water, seek medical advice, do not induce vomiting unless told to by a medical professional
Suitable Extinguishing Media: Use CO2, dry chemical powder, alcohol-resistant foam
Unsuitable Media: Water is not always the best choice here due to chemical reactivity concerns
Special Hazards: Vapors can form explosive mixtures with air; fire may produce irritating or poisonous gases like carbon monoxide and dioxide
Protective Equipment: Firefighters should pull on self-contained breathing apparatus and full protective gear, limit contact with skin and airways
Personal Precautions: Evacuate area if not protected; ventilate; wear chemical splash goggles, gloves, lab coat
Environmental Precautions: Do not let chemical enter drains, sewers, or waterways
Clean-Up Methods: Absorb with sand, vermiculite, or inert material; scoop up, place in chemical waste container, clean spill area thoroughly
Safe Handling: Keep containers sealed when not in use; use in chemical fume hood to minimize inhalation risk; wash hands thoroughly after handling
Storage Conditions: Store in cool, well-ventilated space, away from heat, open flames, and incompatible chemicals like strong bases or oxidizers; avoid direct sunlight
Incompatibilities: Strong bases and oxidizers can react violently, keep away from these chemicals
Engineering Controls: Fume hood essential for adequate ventilation
Personal Protective Equipment: Chemical-resistant gloves, safety goggles, lab coat required; for large quantities or long-term use, consider face shield and respiratory protection
Hygiene Measures: Change contaminated clothing promptly, do not eat or drink near chemical sources
Appearance: Clear to pale yellow liquid
Odor: Strong, sharp
Boiling Point: Ranges near 181-183°C
Melting Point: Not widely reported, usually remains liquid at room temperature
Vapor Pressure: Low at room temperature
Solubility: Slightly soluble in water, highly soluble in organic solvents
Density: Around 1.23–1.25 g/cm³
Chemical Stability: Stable under recommended storage and handling conditions
Hazardous Reactions: Reacts strongly with bases, strong oxidizers, and nucleophiles; may polymerize under alkaline conditions
Decomposition Products: Can produce carbon oxides and other irritant gases if heated strongly or on burning
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Short-term Effects: Burns or irritation to eyes, skin, and airways; headaches, dizziness possible with high exposure
Long-term Effects: No definitive long-term human studies, though continued exposure to high vapor levels brings risk of respiratory and neurologic symptoms
Toxicity Data: Some studies in animals report toxic dose levels at 200–300 mg/kg in rodents
Environmental Mobility: Moderate; likely to bind with soil and organic material, not expected to travel fast through groundwater
Aquatic Toxicity: Harmful to aquatic life at concentrated levels; biodegradation can take time, and so accidental releases in waterways put fish and smaller organisms at risk
Waste Treatment Methods: Incinerate in a chemical incinerator with afterburner and scrubber if possible; follow national hazardous chemical disposal laws
Container Disposal: Triple rinse, remove labels, then dispose of in compliance with local hazard waste rules
UN Number: 2810 (for toxic organic liquids)
Proper Shipping Name: Toxic substances, organic, liquid
Packing Group: III for moderate hazard
Transport Precautions: Packed in tightly closed and leak-proof bottles or drums, clear hazard labels visible; avoid direct sunlight and rough handling; do not stack with incompatible cargo
TSCA (US): Listed
REACH (EU): Registration for use, safety data available for users
Workplace Regulations: OSHA and EU guidelines set exposure limits and require access to safety data and proper labeling, with lab-specific rules in place for universities and research centers
Hazard Communication: Labels and training required for all users before handling; safety instructions visibly posted in storage and use areas
