© 2026 Nanjing Finechem Holdings Co., Ltd,
All Right Reserved
Chemical Name: Diisopropyl Azodicarboxylate
Common Synonyms: DIAD, DEADP
Chemical Formula: C8H14N2O4
Physical Appearance: Yellowish liquid with a faint odor
Recommended Use: Laboratory reagent, organic synthesis
Main Hazards: Exposure can lead to respiratory irritation, skin burns, and eye damage. Prolonged or repeated contact may read as allergic skin reactions. Inhalation sometimes provokes coughing, headaches, or dizziness. Contact with skin, especially if broken, can intensify these effects. Chronic exposure raises risk of respiratory sensitization.
GHS Classification: Flammable liquid (Category 3), Acute toxicity (Category 3, oral and dermal), Skin sensitizer (Category 1)
Pictograms: Flame, Exclamation Mark, Health Hazard
Signal Word: Danger
Hazard Statements: Harmful if swallowed, toxic in contact with skin, may cause allergic skin reaction, flammable liquid and vapor, may cause respiratory irritation
Component: Diisopropyl Azodicarboxylate
CAS Number: 2446-83-5
Concentration: Pure compound or high concentration in commercial bottles
Other Ingredients: No intentional non-active ingredients, though trace impurities and stabilizers can be present from manufacture
Inhalation: Move affected person to fresh air quickly. Seek medical attention for breathing problems or if symptoms persist. Clean air and calm recovery tend to help the most.
Skin Contact: Remove contaminated clothing, flush skin with plenty of water for at least 15 minutes. If rash or irritation develops, consult a doctor.
Eye Contact: Rinse cautiously with water for several minutes, lifting upper and lower eyelids. Remove contact lenses if present and easy to do. Obtain prompt medical help.
Ingestion: Do not induce vomiting. Rinse mouth thoroughly and get immediate medical help. Never try to administer anything by mouth to an unconscious person.
Suitable Extinguishing Media: Use dry chemical powder, carbon dioxide, or alcohol-resistant foam. Water spray can cool containers but might spread flames if applied directly.
Special Hazards: Combustion emits volatile toxic fumes, including nitrogen oxides and carbon oxides. Vapors may form explosive mixtures with air.
Protective Equipment: Firefighters should use self-contained breathing apparatus and full protective clothing. Remove containers from danger zone if it can be done without risk.
Personal Precautions: Evacuate area of unnecessary personnel. Make sure to use appropriate protective gear including gloves, goggles, and chemical-resistant clothing. Avoid breathing vapors or mist.
Environmental Precautions: Prevent product from entering drains, waterways, or soil. Notify authorities if large spills threaten environmental health.
Methods for Cleanup: Absorb spill with inert material like sand or earth. Collect in a tightly sealed container for disposal. Ventilate area thoroughly and wash site after cleanup.
Handling: Always wear chemical-resistant gloves, lab coat, splash goggles, and work in a well-ventilated space, preferably with a fume hood. Avoid all unnecessary exposure and never eat, drink, or smoke near the substance. Open containers carefully to reduce splash and vapor release.
Storage: Store in a cool, dry, properly labeled container kept tightly closed. Keep away from sources of heat, sparks, flames, and direct sunlight. Segregate from incompatible substances like acids, bases, and strong reducing agents.
Engineering Controls: Local exhaust ventilation or a chemical fume hood should run during use. Limit vapor and mist concentrations below recommended thresholds.
Personal Protective Equipment: Wear nitrile or neoprene gloves, chemical-resistant splash goggles, and full-length lab clothing. Respiratory protection may become needed for spills or high vapor concentrations; always rely on a properly fitted respirator with designated chemical cartridges.
Hygiene Measures: Wash hands thoroughly after handling and before eating or drinking. Decontaminate gloves and clothing frequently.
Appearance: Transparent yellowish liquid
Odor: Faint, ester-like
Boiling Point: Roughly 97°C at lower pressure
Melting Point: Below room temperature, forms solid at low temperatures
Flash Point: Approximates 30°C, so treat as a significant fire hazard
Solubility: Miscible with common organic solvents such as acetone and dichloromethane; only slightly soluble in water
Vapor Pressure: Moderate; use care to limit vapor accumulation
Chemical Stability: Stable under recommended handling and storage conditions, sensitive to moisture, acids, strong bases, and reducing agents.
Conditions to Avoid: Excessive heat, open flames, sparks, direct sunlight, and contact with incompatible chemicals. Containers might build pressure over time.
Hazardous Decomposition: Thermal decomposition can produce nitric oxide, nitrogen dioxide, and carbon monoxide. Degradation may also create low molecular weight alcohols and toxic particulates.
Incompatible Materials: Strong acids, strong bases, reducing agents, amines, and some metals.
Routes of Exposure: Inhalation, dermal absorption, ingestion
Acute Effects: Breathing vapors or aerosol can cause respiratory tract irritation, nausea, and headaches. Direct skin exposure sometimes provokes burns, local redness, or allergic responses. Eye contamination leads to pain and severe irritation.
Chronic Effects: Sensitization after repeated skin contact appears in the literature. Animal studies show some evidence for liver and kidney stress at high doses.
Carcinogenicity: Not classified as carcinogenic, but no long-term human data exist.
Aquatic Toxicity: Literature points to moderate toxicity for aquatic invertebrates. Fish and algae could also be affected if levels in water rise.
Persistence and Degradability: Undergoes slow hydrolysis in water; sunlight accelerates breakdown but byproducts can be harmful. Improper disposal may leave residues in soil.
Bioaccumulation: Potential for significant accumulation in aquatic environments remains low, but monitoring is advisable where large quantities might reach the ecosystem.
Waste Treatment Methods: Collect waste in sealed chemical containers. Incinerate in accordance with local and national regulations at a licensed facility equipped to handle nitrogenous waste. Never allow residue to enter drains or natural watercourses.
Contaminated Packaging: Rinse well, then treat as hazardous waste. Use only approved local hazardous waste disposal operations.
Classification: Regarded as a hazardous material for all modes of transport by road, rail, air, and sea.
UN Number: 3242
Packing Group: II
Hazard Class: 3 (Flammable liquids)
Precautions: Keep upright, away from food or feedstuffs, and check for any leaks before shipping. Specialized containers and markings follow regulations in all countries shipping or importing.
Labelling Requirements: Mark all containers clearly according to national and international hazardous substances laws, including risk and safety phrases where required.
Occupational Exposure Limits: Not universally established; occupational best practice dictates stringent engineering controls, regular monitoring, and consistent use of PPE.
Inventory Status: Listed in chemical inventories like REACH and TSCA for laboratory and industrial use, with some import or export restrictions possible.
