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Product Name: Dexametasona
Chemical Name: 9-fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
Synonyms: Dexamethasone
CAS Number: 50-02-2
Recommended Use: Pharmaceutical ingredient, research chemical, corticosteroid medication
Supplier: Major pharmaceutical manufacturers, distributors, research laboratories
Emergency Contact: Local poison control center, medical emergency services, facility safety officer
Classification: Not classified as hazardous under GHS for general handling; possible hazardous effects under prolonged exposure or in large doses
Primary Health Hazards: May cause harm to organs through prolonged or repeated exposure, respiratory tract irritation, eye and skin irritation if handled in bulk
Route of Exposure: Inhalation, ingestion, skin and eye contact
Acute Effects: Headache, dizziness, skin rash, nausea, allergic reactions
Chronic Effects: Immunosuppression, hormonal disturbance, Cushing’s syndrome, adrenal suppression in case of misuse
Environmental Hazards: May pose low risk to aquatic environments with large accidental release
Pictograms: Exclamation mark, health hazard, environment (signal words: Caution, Warning)
Dexametasona (Active Ingredient): Approximately 99% purity
Chemical Formula: C22H29FO5
Other Ingredients: Pharmaceutical excipients, fillers (if in finished dosage forms)
Impurities: Trace synthesis byproducts, less than 1% total
Concentration Range: Used in concentrations from micrograms to milligrams depending on product application
Inhalation: Move exposed persons to fresh air, seek medical attention if symptoms develop
Skin Contact: Wash affected area with soap and water, remove contaminated clothing, consult doctor if rash or irritation appears
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes, remove lenses if present, keep eyelids open, seek medical help
Ingestion: Do not induce vomiting, rinse mouth with water, let medical professionals manage severe cases or accidental overdose
Most Important Symptoms: Allergic manifestations, difficulty breathing, fatigue, unusual sweating, swelling, gastrointestinal symptoms
Notes to Physician: Treat based on clinical judgment, monitor for signs of corticosteroid overdose
Suitable Extinguishing Media: Water spray, foam, dry chemical powder, carbon dioxide
Unsuitable Extinguishing Media: Direct stream of water on burning powder
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, hydrogen fluoride, possible organic compounds
Advice for Firefighters: Use full protective gear, self-contained breathing apparatus, avoid inhalation of smoke or fumes
Specific Hazards: May produce irritating or toxic gases during combustion
Special Procedures: Keep containers cool by spraying with water from safe distance to prevent rupture
Personal Precautions: Wear appropriate protective equipment (gloves, goggles, mask), ventilate area
Methods for Cleaning Up: Collect powder or spilled material with damp disposable towel, transfer to labeled waste container, avoid dust generation
Environmental Precautions: Prevent entry into drains, sewers, soil, and water bodies
Reference to Other Sections: See protection, handling, and disposal guidance for further measures
Noteworthy Procedures: Use HEPA filter vacuum if needed, avoid sweeping dry powder
Precautions for Safe Handling: Use in a well-ventilated area, avoid contact with skin and eyes, prevent dust formation
Storage Conditions: Store in tightly sealed containers, away from light, heat, and moisture
Incompatible Materials: Strong oxidizing agents, acids, alkalis
Handling Practices: Use gloves, wash hands after handling, employ closed handling systems if possible, minimize spillage risk
Special Considerations: Store separately from food and beverages
Occupational Exposure Limits: Not established by OSHA or ACGIH for Dexametasona, apply pharmaceutical exposure guidelines
Engineering Controls: Use process enclosures, local exhaust ventilation, fume hoods
Personal Protective Equipment: Safety goggles, chemical-resistant gloves, lab coat, appropriate respirator for bulk handling
Hygiene Measures: Prohibit eating, drinking, or smoking during use, wash hands thoroughly
Environmental Controls: Control emissions at source, provide spill kits or absorbents near workstations
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not determined
pH: Not applicable (insoluble in water), typically neutral in solution
Melting Point: 262-264°C
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not established
Evaporation Rate: Not applicable
Solubility: Insoluble in water, soluble in ethanol, methanol, chloroform
Partition Coefficient (Log Kow): 1.83—2.1
Vapor Pressure: Negligible at room temperature
Density: Approximately 1.3 g/cm³
Viscosity: Not applicable (solid form)
Chemical Stability: Stable under normal temperature and pressure
Reactivity: Low chemical reactivity under recommended storage and handling
Conditions to Avoid: Excessive heat, open flame, direct sunlight, sources of moisture
Incompatible Materials: Strong acids, strong bases, oxidizing materials
Hazardous Decomposition Products: Fumes of carbon oxides, fluorine compounds
Polymerization: Will not occur under normal circumstances
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Low toxicity by oral and dermal routes in small therapeutic amounts, toxic at large doses
Skin Irritation: Mild to moderate in sensitive individuals
Eye Irritation: May cause temporary discomfort or redness
Chronic Exposure: Prolonged intake or exposure can lead to immunosuppression, bone thinning, hormonal imbalance
Sensitization: Reports of rare allergic reactions that can include swelling, rash, breathing difficulty
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, or OSHA
Mutagenicity: No evidence of mutagenic potential in standard assays
Reproductive Toxicity: Possible risk of harm to fetus in pregnant individuals if used in high doses or extended periods
Aquatic Toxicity: Not considered highly toxic, persistent corticosteroid activity may affect aquatic organisms in significant spills
Persistance and Degradability: Slow degradation in soil and water, stable under environmental conditions
Bioaccumulation Potential: Low tendency to bioaccumulate in aquatic and terrestrial life
Mobility in Soil: Low water solubility limits mobility but may bind to soil particles
Other Adverse Effects: Disruption of hormone activity in sensitive species if continuously released
Product Disposal: Dispose of pharmaceutical waste according to local, state, and federal regulations
Contaminated Packaging: Rinse and dispose using chemical waste procedures or approved waste contractor
Precautions: Do not discharge into surface water, groundwater, soil, or drains
Recycling: Not suitable for chemical recycling
Community Guidance: Use authorized incineration or high-temperature disposal methods
UN Number: Not classified as dangerous goods according to UN Orange Book
Transport Hazard Class: Not regulated for ground, air, or sea transport
Packing Group: Not applicable
Special Precautions: Ship in sealed, labeled containers, protect from moisture and direct sunlight during transit
Environmental Hazards: Not marine pollutant
Safety, Health, and Environmental Regulations: Dexametasona is regulated as a pharmaceutical by health authorities (FDA, EMA, WHO); handled as hazardous substance if in bulk under OSHA or local regulations
USA: Not listed under SARA, CERCLA, TSCA as a hazardous chemical; subject to DEA scheduling and prescription control
Europe: Subject to REACH registration and pharmaceutical directives
Labeling Requirements: Pharmaceutical labeling must include risk advice, handling precautions, health warnings
Other Regulatory Listings: Occupational limits may apply for workers handling active ingredients at manufacturing scale; consult local labor regulations for additional requirements
