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Product Name: Cycloheximide
Chemical Formula: C15H23NO4
CAS Number: 66-81-9
Synonyms: Actidione, Naramycin A
Manufacturer: Prominent chemical suppliers with distribution through laboratory and industrial supply channels
Recommended Use: Research and laboratory applications, protein synthesis inhibition
GHS Classification: Acute toxicity, Oral (Category 2); Acute toxicity, Inhalation (Category 2); Skin irritation (Category 2); Eye irritation (Category 2A)
Signal Word: Danger
Hazard Statements: Fatal if swallowed, inhaled, or in contact with skin; causes skin and serious eye irritation
Pictograms: Skull and crossbones, exclamation mark
Precautionary Statements: Do not breathe dust, avoid contact with skin and eyes, wash thoroughly after handling, use only outdoors or in well-ventilated areas, wear protective gloves and eye protection
Other Hazards: Toxic to aquatic life, prolonged exposure can lead to systemic toxicity and damage vital organs
Chemical Name: Cycloheximide
Concentration: ≥98% (research grade)
Chemical Family: Glutarimide antibiotics
Impurities/Additives: Typically contains trace organic solvents from synthesis, strict quality testing eliminates hazardous co-contaminants before commercial packaging
EC Number: 200-636-0
Relevant Impurities: Free of stabilizers, colorants, or masking agents; formulation and purity based on supplier audit reports
Inhalation: Remove to fresh air, monitor for respiratory distress, seek immediate medical attention, provide artificial respiration if not breathing
Ingestion: Rinse mouth, do not induce vomiting, call poison control center or physician immediately
Skin Contact: Remove contaminated clothing, wash skin with plenty of water and soap for 15 minutes, obtain urgent medical care
Eye Contact: Thoroughly rinse with water for 15 minutes, hold eyelids apart, remove contacts if present and easy to do, immediate ophthalmologist attention important
Advice to Doctor: Treat symptomatically, monitor liver and kidney function, specialist toxicology supervision strongly advised after significant exposure
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Specific Hazards from Combustion: Toxic fumes of nitrogen oxides, carbon monoxide, carbon dioxide may form
Firefighter Precautions: Wear self-contained breathing apparatus, full protective gear
Unusual Fire Hazards: Dust formation increases risk of explosivity in confined or poorly ventilated spaces
Instructions: Cool fire-exposed containers with water spray, fight fire from safe distance, limit spill runoff to prevent entry into waterways
Personal Precautions: Avoid dust generation, ventilate area, keep unprotected people away, use recommended PPE including gloves and tight-fitting goggles
Containment: Prevent leakage into drains, soil, and surface waters using diking or absorbent materials
Clean-Up Methods: Collect spilled material by damp-brushing or vacuuming with HEPA filter, place waste in labeled containers for disposal following local regulations
Environmental Precautions: Avoid release into the environment, toxic to aquatic organisms even in low concentrations
Handling: Work in fume hood or well-ventilated area, avoid generation of dust, keep away from heat, sparks, and open flame, always wear PPE including gloves, lab coat, and respirator where warranted
Hygiene Measures: Wash hands and face thoroughly after use, remove contaminated clothing before entering eating or communal areas
Storage: Store in tightly sealed, original containers in cool, dry, and ventilated area, keep away from sources of ignition, incompatible chemicals, and direct sunlight, designate toxin storage area, restrict access to authorized personnel
Engineering Controls: Use local exhaust ventilation, fume hoods required for weighing and handling operations, maintain negative pressure room where possible
Personal Protective Equipment (PPE): Chemical-resistant nitrile or neoprene gloves, safety goggles or full-face shield, flame-resistant lab coat, NIOSH-approved respirator if airborne concentrations approach permissible limits
Occupational Exposure Limits: No established OSHA or ACGIH limits for cycloheximide, handle as highly hazardous substance
Environmental Controls: Procedures in place to capture and treat all lab exhaust, avoid use in areas with recirculated air without suitable engineering barriers
Appearance: White to off-white crystalline powder
Odor: Odorless or mild earthy scent
Molecular Weight: 281.35 g/mol
Melting Point: 119 – 121°C
Solubility: Soluble in ethanol, methanol, DMSO; slightly soluble in water (10 mg/mL at 20°C)
Boiling Point: Decomposes before boiling
Vapor Pressure: Not significant at ambient temperature
Partition Coefficient (log Kow): 1.5
pH (1% aqueous solution): Approximately neutral
Stability in Light: Sensitive to prolonged exposure, degrades slowly
Chemical Stability: Stable under standard laboratory conditions, avoid contact with oxidizing agents and strong acids
Reactivity: Not reactive with common construction or storage materials
Hazardous Decomposition Products: Thermal decomposition releases hazardous carbon and nitrogen oxides
Conditions to Avoid: Excessive heat, direct sunlight, high humidity can degrade material and diminish efficacy
Polymerization: Not reported to undergo hazardous polymerization under normal storage or use
Acute Toxicity: Oral LD50 (mouse): 2.5 mg/kg; highly toxic via all routes
Potential Health Effects: Ingestion, inhalation, and skin absorption can cause rapid systemic poisoning with nausea, vomiting, ataxia, lethargy, hypotension, and respiratory distress
Chronic Exposure: Prolonged or repeated exposure can cause agranulocytosis, organ damage, teratogenic effects documented in animal models
Carcinogenicity: Not listed as carcinogen by IARC, NTP, or OSHA
Sensitization: No documented cases of skin or respiratory sensitization
Target Organs: Liver, kidneys, central nervous system
Symptoms of Exposure: Confusion, weakness, gastrointestinal disturbances, convulsions in severe cases, fatal poisoning documented with laboratory accidents
Toxicity for Aquatic Organisms: Extremely toxic to fish and aquatic invertebrates, acute EC50 (Daphnia magna) 0.1 mg/L
Persistence and Degradability: Not readily biodegradable, persists in soil and water for weeks under some conditions
Bioaccumulation: Low predicted potential based on log Kow value
Environmental Fate: Rapid inactivation likely in sunlight and under strongly basic conditions, significant risk to non-target organisms near disposal areas
Mobility: Low volatility, moderate binding to soil particles, significant leaching possible in sandy soils or high rainfall areas
Waste Treatment Methods: Treat as hazardous chemical; incinerate with flue gas scrubbing or send to specialized hazardous waste facility only
Container Disposal: Triple rinse containers before disposal, puncture to prevent reuse, label as hazardous waste
Regulatory Requirements: Obtain and comply with local environmental permits, document all waste handling and transport
Recommended Practices: Avoid sewer or public landfill disposal, use designated toxic waste streams, record-keeping of destruction/transfer required
UN Number: UN 2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (Cycloheximide)
Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Labels: Toxic, Handle with care
Special Provisions: Packages require hazard documentation, trained handlers, notification of authorities in case of transportation incidents
Transport in Bulk: Restricted; consult local laws for maximum container volumes and segregation rules
TSCA Status: Listed
REACH Registration: Contact supplier for latest compliance
EPA Regulations: Listed as toxic; subject to strict reporting and spill notification laws
SARA Section 313: Subject to reporting under community right-to-know
WHMIS Classification (Canada): D1A, D2B (very toxic), E (corrosive)
OSHA: Regulated under Hazard Communication Standard
Other Information: Use controlled access, regular employee health monitoring, comprehensive chemical hygiene plan driven by local occupational health and safety authority
