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Material Safety Data Sheet (MSDS) – Cryostor(R) Cell Cryopreservation Media

Identification

Product Name: Cryostor(R) Cell Cryopreservation Media
Synonym: Cell preservation solution
Recommended Use: Laboratory cell preservation
Supplier: Biolife Solutions Inc.
Contact: Emergency and information contact numbers supplied on primary labeling
Product Code: As indicated on packaging documentation
Emergency Phone: Refer to regional poison control center or company-provided number
Intended Users: Laboratory professionals trained in biological substance handling

Hazard Identification

GHS Classification: Not hazardous under normal laboratory use
Signal Word: None required
Pictograms: None
Potential Health Effects: Minor skin or eye irritation with direct, extended contact; avoid ingestion or inhalation; unlikely to cause significant acute health effects in typical settings
Precautionary Statements: Avoid unnecessary contact with skin and eyes; use standard laboratory safety measures
Hazard Statements: Not considered hazardous by OSHA or EU regulation 1272/2008/EC
Other Hazards: Direct contact may cause mild transient irritation due to chemical nature of preservatives (e.g., DMSO)

Composition / Information on Ingredients

Key Ingredients: Dimethyl sulfoxide (DMSO), buffered saline solutions, human serum albumin or recombinant analogs (component lists may vary by catalog number)
Chemical Identity: DMSO: CAS 67-68-5, Albumin (human or recombinant): CAS varies by source
Concentration: DMSO (5%–10%); Albumin or synthetic proteins (1%–10%); other buffers and salts (0.1%–5%)
Impurities: Quality controlled to limit biologically significant contaminants; supplied sterile-filtration grade
Additional Notes: Free of animal-origin components unless labeled; check lot-specific certificates for exact composition profiles

First Aid Measures

Skin Contact: Wash thoroughly with soap and water; remove contaminated clothing
Eye Contact: Rinse eyes cautiously with water for several minutes; seek medical attention for persistent irritation
Inhalation: Move person to fresh air; seek medical attention if symptoms persist
Ingestion: Rinse mouth with water; do not induce vomiting; seek medical guidance
Signs/Symptoms: Mild irritation, redness, transient discomfort

Fire-Fighting Measures

Flammability: Non-flammable aqueous solution
Suitable Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide as appropriate for the surrounding material
Hazardous Combustion Products: Limited; may emit carbon oxides or sulfur oxides if heated excessively
Special Protective Equipment: Standard fire-fighting gear; self-contained breathing apparatus as a precaution with large quantities
Explosion Data: Not explosive

Accidental Release Measures

Personal Protection: Use gloves, eye protection, and lab coats
Spill Containment: Stop leak if safe; absorb with inert material (e.g., paper towels, absorbent pads)
Clean-Up Procedure: Wipe up, place in closed container for disposal; disinfect spill area with suitable cleaner
Ventilation: Ensure adequate air circulation
Environmental Protection: Prevent large quantities from entering drains or open water sources

Handling and Storage

Handling Precautions: Avoid contact with skin, eyes, and clothing; use in a controlled laboratory environment
Storage Conditions: Store between -20°C and -80°C or as specified; avoid repeated freeze-thaw cycles
Incompatible Materials: Strong oxidizing agents; check for incompatibility before mixing with other chemicals
Instructions for Open Containers: Reseal tightly after use; label with date opened
Safe Transfer: Use pipettes or dispensers; minimize splash risk

Exposure Controls and Personal Protection

Engineering Controls: Use biological safety cabinet or fume hood in case of aerosol risk
Eye Protection: Safety goggles or face shield
Glove Type: Nitrile or latex gloves
Clothing: Standard lab coat
Hygiene Measures: Wash hands after handling; do not eat or drink in laboratory
Exposure Limits: DMSO: ACGIH TLV not established, follow institutional guidelines

Physical and Chemical Properties

Appearance: Colorless to pale yellow, clear liquid
Odor: Characteristic mild, related to DMSO
pH: 6.8–7.4
Melting Point/Freezing Point: Below -10°C (due to DMSO and buffer)
Boiling Point: Not applicable (aqueous solution)
Flash Point: Not applicable
Solubility: Completely soluble in water
Vapor Pressure: Negligible at room temperature
Density: 1.05–1.10 g/cm³

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions
Reactivity: Will not polymerize; stable under normal laboratory conditions
Materials to Avoid: Strong acids, alkalis, and oxidizers
Conditions to Avoid: Excess heat, direct sunlight, repeated freeze-thawing
Hazardous Decomposition Products: Under fire conditions, could form carbon or sulfur oxides

Toxicological Information

Acute Toxicity: Low; DMSO can cause skin to become more permeable; limited toxicity for typical lab use
Chronic Effects: No known long-term risks at occupational exposure levels
Sensitization: No known sensitizing effects
Carcinogenicity: Components not listed as carcinogenic by IARC, NTP, or OSHA
Reproductive/Developmental Toxicity: Not expected at concentrations used; DMSO has shown minimal effects at much higher exposures
Routes of Exposure: Skin, eyes, ingestion, and inhalation
Symptoms: Redness, irritation, very mild discomfort

Ecological Information

Ecotoxicity: Not toxic in dilute laboratory applications
Persistence and Biodegradability: DMSO and albumin degrade rapidly in environmental settings
Mobility in Soil: High; will dilute and disperse easily
Bioaccumulation: Components do not bioaccumulate
Aquatic Toxicity: Low risk at controlled laboratory release levels
Other Adverse Effects: Prevent large volumes from entering waterways to avoid unexpected effects

Disposal Considerations

Waste Disposal Method: Dispose in accordance with local, state, and federal regulations
Container Disposal: Rinse and recycle or dispose as hazardous laboratory waste
Recommended Procedure: Consult institutional hazardous waste guidelines; do not pour into drains
Incineration: Permissible for large volumes, if allowed by authority
Precautions: Always wear gloves and eye protection during disposal

Transport Information

UN Number: Not regulated for ground or air transport
Proper Shipping Name: Not classified as dangerous goods
Hazard Class: None assigned
Packing Group: Not applicable
Environmental Hazards: None significant in shipped quantities
Special Precautions: Ship with temperature control, use leak-proof secondary containment

Regulatory Information

Safety, Health, and Environmental Regulations: Product complies with OSHA, EU CLP (EC 1272/2008), and GHS standards as a non-hazardous preparation
SARA Title III Section 313: Not subject to reporting
TSCA Inventory: All components listed
DSL/NDSL (Canada): All components listed or exempt
EINECS/ELINCS (EU): Components compliant
Labeling Requirements: Manufacturer includes precautionary and safe handling recommendations
REACH Registration: In compliance where required