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Common Name: Coomassie Brilliant Blue G-250
Chemical Family: Triphenylmethane dye
Chemical Formula: C47H48N3O7S2
Appearance: Deep blue to violet powder
Odor: No significant odor
Primary Uses: Used mostly in protein staining, particularly with Bradford assays
Users: Researchers, lab technicians, students, professionals working with proteins in biochemistry and molecular biology environments
Hazard Classification: Eye and skin irritant
Acute Effects: Contact may trigger mild to moderate irritation, especially if powder reaches mucous membranes
Chronic Risks: Prolonged inhalation of dust may irritate respiratory tract; hazardous mainly in unguarded bulk handling
Signal Word: Warning
Pictograms: Exclamation mark for irritation
Most Common Exposure Routes: Inhalation, skin contact, eye contact, accidental ingestion
Main Ingredient: Coomassie Brilliant Blue G-250 (CAS 6104-59-2)
Concentration: Generally available at greater than 98% purity
Impurities: Trace levels of salts or synthesis byproducts may exist based on the grade
Eye Contact: Immediate rinsing with plenty of water for several minutes, removal of contact lenses if present, and medical attention if irritation persists
Skin Contact: Rinse with soap and water, remove contaminated clothing
Inhalation: Move person to fresh air, observe for respiratory discomfort, seek medical assistance if symptoms remain
Ingestion: Rinse mouth with water, do not induce vomiting, call a physician if feeling unwell
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical powder, or carbon dioxide
Combustion Products: Burning may produce carbon oxides, nitrogen oxides, sulfur oxides
Advice for Firefighters: Wear self-contained breathing apparatus, protective clothing for fire and chemical exposure
Specific Hazards: Powder is combustible; avoid dust accumulation near ignition sources
Personal Precautions: Use gloves, lab coats, safety goggles, and dust masks if available
Spill Containment: Avoid raising dust, sweep with damp cloth or use HEPA filter vacuum
Cleaning Procedures: Collect residue in sealed containers, wash area with water and detergent
Environmental Precautions: Prevent entry into drains or waterways, especially in concentrated quantities
Handling: Use in well-ventilated areas, avoid direct contact with skin, eyes, and clothing
Manual Techniques: Transfer with minimum dust release, keep containers tightly closed
Storage: Store at room temperature in tightly-sealed containers, away from food, acids, oxidizers, and sources of ignition
Special Notations: Label storage space and keep out of reach of minors not trained in lab safety
Engineering Controls: Laboratory fume hoods or local exhaust ventilation help decrease airborne dust
Protection: Gloves (nitrile or latex), safety glasses or face shields, disposable lab coats
Respiratory: NIOSH-approved dust mask if dusting becomes a concern
Hygiene Practices: Wash hands after use, do not eat, drink, or smoke during or after handling
Physical State: Solid powder
Color: Blue to purple
Odor: Nearly odorless
Solubility: Soluble in water and slight in ethanol or methanol
Melting Point: Information often not broadly specified but stable under standard laboratory conditions
Boiling Point: Not applicable
Flash Point: Not considered highly flammable but fine powder form increases risk near ignition sources
pH (aqueous solution): Slightly acidic
Chemical Stability: Stable under regular storage and handling
Conditions to Avoid: Strong oxidizers, strong acids, direct sources of heat and ignition
Hazardous Decomposition: Burning releases carbon, nitrogen, sulfur oxides
Incompatibilities: Strong oxidizing agents, strong acids
Acute Toxicity: Data specific to humans is scarce, but low toxicity typical at laboratory exposure levels
Skin/Eye Irritation: Mild to moderate irritant
Carcinogenic Status: Not classified as carcinogenic by established agencies
Long-Term Exposure: Prolonged exposure can cause dermatitis in sensitive users, repeated inhalation of dust should be avoided
Sensitization: Typically rare
Aquatic Toxicity: Moderate hazard to aquatic organisms at high concentrations
Degradability: Not readily biodegradable, persistent nature highlights the importance of proper waste management
Bioaccumulative Potential: Limited data, persistence suggests possible accumulation risk over extended releases
Waste Management: Collect and dispose through approved chemical waste processing, avoid general sewage or landfill disposal
Container Disposal: Triple rinse and deface container labels
Regulatory Status: Do not treat as ordinary waste, due to environmental persistence
Advice for Laboratories: Coordinate with institutional environmental health and safety offices for large-scale disposal
Transport Classification: Not regulated as a hazardous material in small, laboratory-scale quantities
Packing Instructions: Use sealed, correctly labelled containers, package to prevent dust and pigment release
Special Handling: Maintain documentation about dye content in transported goods
Regulatory Listings: Typically listed under general laboratory chemical regulations for non-volatile dyes
Workplace Labels: Label for proper handling precautions, avoid transfer to food or medical containers
Additional Precautions: Provide training to users about the risks of fine particulate chemicals, highlight persistence in the environment
