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Product Name: COMPLETE TM MINI EDTA-FREE PROTEASE
Product Code: 11836153001
Manufacturer: Sigma-Aldrich, Merck KGaA
Recommended Use: Laboratory reagent, protease inhibition
Synonyms: Protease Inhibitor Cocktail, Mini Tablets, EDTA-Free
Supplier Contact: Customer Service, Phone: +1-800-XXX-XXXX
Emergency Phone Number: CHEMTREC: +1-800-424-9300
Address: 3050 Spruce Street, St. Louis, MO 63103, USA
Classification: Mixture not classified as hazardous according to OSHA Hazard Communication Standard
Signal Word: None
Hazard Statements: May cause mild skin and eye irritation in sensitive individuals
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, use only with adequate ventilation
Pictograms: None required
Hazards Not Otherwise Classified: May cause allergic reactions in predisposed persons; not intended for human or animal consumption
Component: Protease Inhibitors (Proprietary blend, exact concentrations withheld as trade secret)
CAS Number: Mixture (Protease Inhibitor components include Aprotinin, Leupeptin hemisulfate salt, Pepstatin A, Bestatin, E-64, Pefabloc SC, among others)
Concentration: Each tablet formulated for 10 mL extraction buffer
Other Components: Sucrose, Sodium chloride, Magnesium chloride (in trace amounts)
Additional Information: Contains no EDTA
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, seek medical attention if irritation persists
Skin Contact: Wash skin thoroughly with soap and water, take off contaminated clothing and wash before reuse
Inhalation: Move to fresh air, provide artificial respiration if not breathing, seek medical attention if symptoms develop
Ingestion: Do not induce vomiting, rinse mouth with water, seek immediate medical advice
Most Important Symptoms: May provoke mild irritation, allergic reactions rarely reported
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical, foam
Specific Hazards: Combustion releases toxic fumes of carbon oxides, nitrogen oxides, and sulfur oxides
Protective Equipment: Wear self-contained breathing apparatus and full protective gear
Firefighting Instructions: Prevent firefighting runoff from entering waterway, use caution as containers may become pressurized in heat
Personal Precautions: Use personal protective equipment, avoid formation and inhalation of dust, ensure adequate ventilation
Environmental Precautions: Prevent product from entering drains and waterways
Methods for Cleanup: Sweep up material, place in suitable container for chemical waste, clean contaminated area with water and detergent, avoid dry sweeping to minimize dust^
Handling: Wear protective gloves, eyewear and clothing; avoid dust formation, use only in well-ventilated area; do not ingest or inhale
Storage: Store at 2-8°C, keep containers tightly closed and protected from light; do not freeze; keep only in original container
Incompatible Materials: Strong oxidizing agents
Engineering Controls: Work in chemical fume hood or well-ventilated area
Eye Protection: Safety goggles compliant with EN166
Skin Protection: Nitrile or similar chemical-resistant gloves, lab coat
Respiratory Protection: Dust mask (NIOSH or EN 149) as needed for airborne particulates
Hygiene Measures: Wash thoroughly after handling, avoid eating or drinking in laboratory
Appearance: White to off-white tablet
Odor: Odorless
Odor Threshold: Not established
pH (Solution): Neutral in 50 mM Tris-HCl buffer
Melting Point: Not applicable
Freezing Point: Not applicable
Boiling Point: Not applicable
Flash Point: Not determined
Evaporation Rate: Not applicable
Flammability: Not flammable
Solubility: Soluble in water or buffer
Vapor Pressure: Not applicable
Vapor Density: Not applicable
Relative Density: Not determined
Partition Coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: Not determined
Decomposition Temperature: >120°C
Viscosity: Not applicable
Stability: Stable under recommended storage and handling conditions
Reactivity: No known hazardous reactions
Conditions to Avoid: Extended exposure to high temperatures, moisture, and alkaline pH
Incompatible Materials: Strong acids, strong oxidizers
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, sulfur oxides on combustion or thermal decomposition
Acute Toxicity: No acute toxicity reported at product use concentrations
Chronic Toxicity: Chronic exposure unlikely during proper laboratory use
Skin Corrosion/Irritation: May cause mild skin irritation in sensitive users
Eye Damage/Irritation: May cause transient eye irritation
Respiratory Sensitization: Inhalation of dust could provoke allergic response in sensitized persons
Germ Cell Mutagenicity: Not classified
Carcinogenicity: No components classified as carcinogenic by IARC, NTP, or OSHA
Reproductive Toxicity: No evidence of reproductive toxicity
Symptoms: Redness, itching, sneezing, coughing if exposed to dust
Target Organ Effects: No known effects on specific organs under normal use
Ecotoxicity: Not classified as harmful to aquatic life in laboratory-scale release scenarios
Persistence and Degradability: Components are biodegradable or decompose with natural processes
Bioaccumulation Potential: Not known to bioaccumulate
Mobility in Soil: Expected to have low mobility due to high solubility and ready degradation
Other Adverse Effects: Avoid discharge into the environment
Product Disposal: Collect excess material, place in appropriate container for chemical waste, dispose according to local, state, and federal regulations
Contaminated Packaging: Dispose of as unused product
Special Precautions: Do not discharge into drains or waterways; follow institutional guidelines for laboratory waste disposal
UN Number: Not regulated as dangerous goods
UN Proper Shipping Name: Not classified for transport
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not considered marine pollutant
Special Precautions for Transport: Protect from high temperatures and moisture during transit
US Regulation: Not subject to reporting requirements under SARA Title III, TSCA inventory exempt
EU Regulation: Does not require classification or labeling under CLP Regulation (EC) No. 1272/2008
Canada: Not listed on the Domestic Substances List
Other International: No REACH registration required for formulated products
Labeling: Intended for research/laboratory use only, not for drugs, household, or other uses
