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Product Name: Colchicine
Chemical Name: N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide
Synonyms: Colchicinum, Colcrys
CAS Number: 64-86-8
Recommended Use: Treatment of gout, research, laboratory use
Manufacturer: Reference on packaging
Emergency Contact: Refer to institutional emergency plan
Classification: Acute Toxicity (Oral) Category 2, Skin Irritation Category 2, Eye Irritation Category 2A
Signal Word: Danger
Hazard Statements: Toxic if swallowed, toxic in contact with skin, may cause damage to organs through prolonged or repeated exposure
Pictograms: Skull and crossbones, exclamation mark, health hazard
Routes of Exposure: Inhalation, skin contact, ingestion
Symptoms: Nausea, vomiting, abdominal pain, multi-organ dysfunction, respiratory distress, potential death if untreated
Chemical Formula: C22H25NO6
Purity: Typically >98% for laboratory use
Components: Colchicine (active ingredient)
Impurities: Trace alkaloids, solvents from synthetic process
Inhalation: Move to fresh air, keep at rest, monitor respiratory function, call medical help
Skin Contact: Remove contaminated clothing, rinse skin for at least 15 minutes, wash thoroughly, seek medical attention
Eye Contact: Rinse eyes cautiously with water for several minutes, remove contact lenses if present, continue rinsing, seek immediate medical help
Ingestion: Rinse mouth, do not induce vomiting, offer water if conscious, urgent medical attention required
Most Important Symptoms: Nausea, abdominal pain, severe gastrointestinal distress, cardiovascular and renal toxicity, rapid onset of symptoms
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide
Unsuitable Media: Direct water stream on containers may spread fire
Hazards from Combustion: Produces carbon oxides, nitrogen oxides, methyl ether fumes
Protective Equipment: Self-contained breathing apparatus, full protective gear
Special Procedures: Avoid fumes, use water to cool containers, contain run-off
Personal Precautions: Evacuate area, avoid breathing dust, wear gloves and eye protection, use respirator if dust forms
Environmental Precautions: Prevent entry into drains, soil, waterways
Cleanup Methods: Scoop up spilled solid carefully and place in properly labeled container, ventilate area, wash spill site with soap and water after cleanup
Handling: Use within a chemical fume hood, avoid dust generation, minimize contact, avoid ingesting or inhaling
Storage Conditions: Store in cool, dry, well-ventilated area, tightly sealed container, protected from light and incompatible materials (strong oxidizer agents)
Incompatibilities: Strong oxidizing agents, acids/bases
Safe Practices: Label containers clearly, restrict access to trained personnel, use secondary containment
Exposure Limits: No established OSHA/ACGIH limits, handle as highly toxic
Engineering Controls: Chemical fume hood required, local exhaust recommended
Personal Protective Equipment: Nitrile/lab-grade gloves, long-sleeved lab coat, chemical splash goggles, NIOSH-approved respirator for dusts/fumes
Hygiene Measures: Remove and wash contaminated clothing before reuse, wash hands thoroughly after handling, no eating/drinking/smoking in work area
Appearance: Yellow-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH (solution): Slightly acidic
Melting Point: 155°C – 157°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Evaporation Rate: Not determined
Solubility: Easily soluble in water, methanol, ethanol, chloroform
Partition Coefficient (log Kow): ~0.2
Vapor Pressure: Negligible
Density: 1.33 g/cm³
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Thermal Decomposition: Releases toxic fumes at high temperatures
Hazardous Reactions: Reacts with strong oxidizers
Conditions to Avoid: Heat, moisture, incompatible materials
Polymerization: Will not occur
Incompatible Materials: Oxidizing agents, acids, bases
Acute Toxicity (Oral): LD50 (oral, rat): ~6 mg/kg
Acute Toxicity (Dermal): Data limited, considered similar to oral
Inhalation Toxicity: No robust animal data, likely toxic by inhalation
Skin/Eye Damage: Causes serious irritation and possible chemical burns
Chronic Exposure: Bone marrow suppression, neuropathy, leukopenia
Carcinogenicity: Not classified by IARC/NTP/OSHA
Mutagenicity: Evidence from animal tests for chromosomal changes
Other Effects: May suppress fertility, highly toxic in overdose
Ecotoxicity: Highly toxic to aquatic organisms, long-term adverse effects in aquatic environments
Mobility: Reasonable mobility in soil, leaching risk to groundwater
Persistence/Degradability: Degrades slowly in environment, potential for bioaccumulation limited
Bioaccumulation: Log Kow suggests not expected to bioaccumulate significantly
Additional Information: Do not allow product or runoff to reach waterways, inform authorities if spill reaches environment
Waste Disposal: Dispose as hazardous chemical waste, use incineration in authorized facilities
Container Disposal: Triple rinse with compatible solvent, offer for recycling if possible
Precautions: Avoid release to environment, comply with local, state, and federal regulations
Recommended Procedures: Label as "hazardous toxics", notify waste handler of nature of material
UN Number: UN 2811
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (contains Colchicine)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Marine Pollutant: Yes
Special Precautions: Secure containers, clearly label, emergency procedures required during transport
Regulations: Subject to requirements of DOT, IATA, IMDG for hazardous substances
TSCA: Listed
EU Classification: Highly toxic, dangerous for the environment
SARA 302/313: Not listed
OSHA: Regulated as acutely toxic substance
WHMIS (Canada): Class D1A (very toxic), D2B (toxic)
REACH: Subject to restrictions under Annex XVII as toxic chemical
Other Regulations: Comply with country-specific hazardous material regulations, labelling requirements, workplace exposure monitoring
