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Chemical Name: Chrysine
Synonyms: 5,7-Dihydroxyflavone
Chemical Formula: C15H10O4
Physical Appearance: Pale yellow crystalline solid
Common Uses: Used mainly in research, found in honey, bee propolis, and certain plants, often investigated for antioxidant and health-related properties.
CAS Number: 480-40-0
Hazard Classification: No major legislation classifies chrysine as hazardous in typical quantities, but laboratory-scale handling calls for respect.
Hazard Statements: Dust may irritate respiratory tract, eyes, or skin on prolonged contact.
Signal Word: None usually provided under standard lab conditions, but eye and skin irritation gets a mention.
GHS Pictograms: Ordinary research settings list no pictogram, yet working with unknowns involves staying vigilant.
Main Ingredient: Chrysine at high purity
Impurities: Trace amounts can include botanically-derived analogues, depending on source.
Mixtures: Research grade chrysine typically sold as a single ingredient.
Eye Contact: Rinse eyes promptly with plenty of water; keep eyelids apart and continue flushing for at least 15 minutes.
Skin Contact: Wash with soap and water; remove contaminated clothing to prevent irritation.
Inhalation: Move to fresh air if inhaling significant dust, and seek help if coughing or trouble breathing continues.
Ingestion: Rinse mouth with water; if symptoms appear or large amounts are swallowed, seek medical advice.
Suitable Extinguishing Media: Use dry powder, carbon dioxide, or foam.
Special Hazards: Combustion can generate irritating or toxic fumes—think carbon oxides, not just simple smoke.
Protective Equipment: Firefighters need self-contained breathing apparatus and protective clothing to minimize inhalation and skin exposure.
Explosion Risk: No unusual risk, yet powders always carry the potential for fine dust fires in enclosed spaces.
Personal Experience: Even substances lacking strong flammability ratings deserve vigilance; research laboratory fires often start where you least expect.
Personal Precautions: Don a dust mask, gloves, and eye protection—sweeping up powders often kicks particulates into the air.
Environmental Precautions: Contain any spillage to prevent it entering water systems, especially when working in tight laboratory quarters.
Clean-up Methods: Sweep up carefully without raising dust, collect in a sealable container for proper disposal, and ventilate the area until the air clears.
Shared Labs: Everyone in the workspace must know the substance you’re cleaning, as even minor spills can trigger allergy or irritation in sensitive colleagues.
Handling: Minimize dust generation, keep containers tightly closed, and always use personal protection if handling quantities larger than a few milligrams.
Storage Conditions: Store in a cool, dry, and well-ventilated place, away from moisture and direct sunlight.
Incompatible Materials: Avoid storing with strong oxidizers or bases.
Lab Lessons: Once, a vial of chrysine left uncapped in a humid room caked up and became tough to dissolve—a little care in dry storage saves research headaches.
Engineering Controls: Fume hood or exhaust ventilation when weighing or transferring powders.
Personal Protective Equipment: Eye protection, lab coat, Nitrile gloves, and dust mask when working with fine powder.
Hygiene Measures: Wash hands before breaks and after handling, and never eat or drink in work areas.
Monitoring: Direct exposure limits rarely set for chrysine, but smart researchers monitor the overall load of particulate matter in air.
Appearance: Pale yellow powder or crystals
Odor: Nearly odorless
Melting Point: Roughly 285 to 287°C
Solubility: Sparingly soluble in water, more so in organic solvents like ethanol and DMSO
Vapor Pressure: Negligible under normal lab conditions
Molecular Weight: 254.24 g/mol
Density: Approximately 1.54 g/cm³
Remark: Inconsistent solubility frustrates many first-timers—planning your solvent system in advance is part of responsible research.
Chemical Stability: Stable under standard lab settings, though exposure to air and moisture over time can degrade purity.
Reactivity: Limited in most ambient conditions; reacts with strong oxidizers.
Hazardous Decomposition: Heating to decomposition releases carbon oxides.
Storage Mishaps: Forgotten vials exposed to the open air often show changes in color, a warning that something's altering in the compound itself.
Acute Toxicity: No solid data for humans, low acute toxicity in animal studies, but effects remain incompletely studied.
Routes of Exposure: Skin, eye, inhalation of dust, and accidental ingestion.
Irritation: Can cause temporary irritation especially to eyes and mucous membranes.
Chronic Effects: Little data; long-term risks, including reproductive or carcinogenic risks, lack enough study for clear statements.
Self-Protection: No matter how ‘non-toxic’ a plant-derived compound seems, caution beats regret every time.
Ecotoxicity: No significant issues identified for small-scale research; large discharges to water or soil should never be routine.
Persistence and Degradability: Likely degrades over time under sunlight and microbial action.
Bioaccumulation: Unlikely based on structure and low environmental persistence, but detailed bioaccumulation data stays scarce.
Good Practices: Never wash lab residues down the drain without assessing the batch size—collect and dispose as chemical waste.
Waste Handling: Treat as non-hazardous organic laboratory waste in most settings, but comply with regional disposal rules.
Container Disposal: Rinse containers thoroughly before discarding, and send to specialized chemical waste handlers if in doubt.
Lab Lowdown: Every university lab I’ve worked in collected all organics—no matter their perceived safety. Regulations trump opinion, every time.
UN Number: Not assigned for small quantites used in research.
Transport Hazard Class: Not regulated as a dangerous good for standard research shipments.
Packing Group: Not required.
Transportation Advice: Ship in well-sealed, labeled containers; avoid temperature extremes which can alter compound integrity.
Shipping: Academic courier services prefer double-containment and clear labeling; customs delays often come from unclear documentation even for benign compounds like chrysine.
Classification: Not a controlled or scheduled substance under most jurisdictions.
Local Laws: Each country sets its own reporting thresholds for new chemicals; researchers should check institutional guidelines.
Lab Policy: Even minor compounds need tracking—misplaced vials and unlabeled containers cause headaches when audits roll around.
