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Product Name: Cholera Toxin
Chemical Family: Bacterial Protein Toxin
Synonyms: Vibrio cholerae Enterotoxin
CAS Number: 9012-63-9
Manufacturer: Research supply company or relevant laboratory
Product Use: Laboratory reagent, research applications
Contact Information: Refer to supplier address and emergency phone number as listed on packaging
Hazard Classification: Acute Toxicity (Oral, Inhalation, Dermal), Eye Damage/ Irritation, Specific Target Organ Toxicity
GHS Label Elements: Skull and crossbones, Exclamation mark
Signal Word: Danger
Hazard Statements: Toxic if swallowed, in contact with skin or if inhaled. Causes serious eye damage. May cause damage to organs.
Precautionary Statements: Avoid all routes of exposure. Wear appropriate protective gear. Seek immediate medical advice if exposed.
Chemical Name: Cholera Toxin
Chemical Formula: C57H97N17O30S
Purity: Often 80-98% (depending on supplier)
Impurities: Usually contains residual buffer salts, traces of Vibrio cholerae proteins
Component: Multi-subunit protein complex, includes A and B subunits
General: Remove from exposure and move to fresh air or clean environment.
Inhalation: Move to fresh air immediately. If difficult to breathe, provide oxygen and seek medical attention quickly.
Skin Contact: Rinse off with plenty of water while removing contaminated clothing. Seek medical help if irritation or symptoms develop.
Eye Contact: Rinse immediately with large quantities of water for at least 15 minutes. Ensure eyelids are held open and seek medical advice.
Ingestion: Do not induce vomiting. Rinse mouth thoroughly. Get immediate medical support.
Note To Physician: Treat symptomatically, monitor for systemic toxicity, provide supportive care as required.
Flammability: Not flammable, but decomposition may produce hazardous gases.
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical or foam.
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides
Special Protective Equipment for Firefighters: Use full protective gear and self-contained breathing apparatus.
Precautions: Avoid inhalation of gases and dusts created during fire. Evacuate area if necessary.
Personal Precautions: Avoid dust formation and direct contact. Ventilate contaminated space. Use personal protective equipment.
Environmental Precautions: Prevent further leakage or entry into waterways, drains, or sewers.
Methods for Clean Up: Use inert material to pick up spilled toxin. Place in marked container for safe disposal. Decontaminate area using approved disinfectant.
Emergency Procedures: Isolate area and prevent unauthorized access.
Handling: Avoid inhalation, contact with skin, eyes, and clothing. Always practice good industrial hygiene and use containment equipment. Handle inside biological safety cabinet if available.
Storage: Store refrigerated (typically at 2–8°C), protected from light and away from food, animals, and incompatible materials.
Incompatibilities: Avoid exposure to strong acids, bases, and oxidizing agents.
Packaging Materials: Use only containers designed to prevent leaks and contamination.
Exposure Limits: No established occupational exposure limits. Treat as a highly hazardous agent.
Engineering Controls: Work in ventilated spaces, preferably in a certified fume hood or biosafety cabinet. Use proper containment for experimental work.
Personal Protective Equipment (PPE): Wear laboratory gloves (nitrile or equivalent), lab coat, safety goggles or glasses, and mask or respirator as appropriate. Ensure eyewash stations and safety showers remain accessible.
Hygiene Measures: Wash hands and exposed skin thoroughly after handling, before eating or drinking, and after removing PPE.
Appearance: Lyophilized powder or crystalline solid, white to off-white
Odor: Odorless
Solubility: Soluble in water, phosphate-buffered saline
pH: Neutral to slightly basic (reconstituted aqueous solution)
Molecular Weight: Approximately 84 kDa (hexameric complex)
Melting Point: Decomposes before melting
Boiling Point: Not applicable
Flash Point: Not applicable
Chemical Stability: Stable under recommended storage conditions.
Reactive With: Strong acids, bases, oxidizers
Decomposition Products: Hazardous gases including CO, CO2, NOx, SOx may form during fire or extreme thermal decomposition.
Polymerization: Does not undergo hazardous polymerization.
Acute Toxicity: Highly toxic protein toxin; LD50 (mouse, intraperitoneal) estimated at about 10 μg/kg.
Routes of Exposure: Inhalation, ingestion, dermal, ocular
Symptoms: Severe diarrhea, vomiting, dehydration, abdominal cramps, shock, death in acute exposures
Chronic Effects: Unknown, but not classified as a carcinogen
Target Organs: Intestines, cardiovascular system
Aquatic Toxicity: Avoid release in environment; based on protein nature, may present hazard to aquatic organisms.
Persistence and Degradability: Biodegradable under suitable environmental conditions.
Bioaccumulative Potential: Not expected to bioaccumulate.
Mobility in Soil/Water: Mobile in water; binds poorly to soil.
Other Information: Proper disposal prevents ecological risk.
Waste Disposal: Dispose of as hazardous biological waste in accordance with institutional and local regulations. Use autoclaving or incineration for biological inactivation.
Contaminated Packaging: Treat empty containers with same precaution as product; dispose through approved facilities.
Precautions: Avoid release to environment. Document all disposal activities as required by law.
UN Number: UN 3462
Proper Shipping Name: Toxins, extracted from living sources, solid, n.o.s.
Hazard Class: 6.1 (Toxic Substances)
Packing Group: I (highest hazard level)
Transport Labels: Toxic, Biological Hazard
Special Precautions: Ensure secure, labeled packaging. Comply with International Air Transport Association (IATA), International Maritime Dangerous Goods (IMDG), and relevant national transport regulations.
Transport Documents: Include safety data and emergency procedures in shipment documentation.
Relevant Regulations: Controlled under national/international regulations for toxins (e.g., CDC, WHO, United States Select Agent Program).
Inventory Listings: Not listed in common chemical inventories (e.g., TSCA, EINECS), but regulated as a select agent.
Labeling: Requires hazard and biohazard symbols, risk and safety phrases according to OSHA, GHS, and local authorities.
Restrictions: Distribution and usage restricted to trained personnel, research institutions, with required permits
Other Requirements: Maintain thorough records of acquisition, usage, storage, and disposal for audit and compliance purposes.
