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Product Name: Chloroform-d
Chemical Name: Deuterochloroform
Synonyms: CDCl3, Chloroform-D, Methylidyne trichloride-d
CAS Number: 865-49-6
Molecular Formula: CDCl3
Recommended Use: Laboratory solvent, used in NMR spectroscopy
Manufacturer Information: Major chemical suppliers, contact data on invoice or label
Emergency Phone Number: Provided by supplier or CHEMTREC: 1-800-424-9300
Hazard Classification: Acute toxicity (Oral, Dermal, Inhalation), Skin irritation, Eye irritation, Carcinogenicity, Specific target organ toxicity (repeated exposure)
GHS Label Elements: Danger
Hazard Statements: Harmful if swallowed, in contact with skin, or if inhaled; Suspected of causing cancer; Causes serious eye irritation; Causes skin irritation; May cause damage to organs through prolonged or repeated exposure (liver, kidneys, central nervous system)
Precautionary Statements: Avoid breathing dust, fumes, gas, mist, vapors, sprays; Wear appropriate protective equipment; Wash hands thoroughly after handling; Use only outdoors or in a well-ventilated area; Keep away from open flames, heat, and sources of ignition
Routes of Exposure: Inhalation, Skin contact, Eye contact, Ingestion
Chemical Name: Deuterochloroform
Concentration: Greater than 99%
CAS Number: 865-49-6
Impurities: Possible trace amounts of undeuterated chloroform, iron-compounds, and residual moisture below 0.05%
Stabilizer: Some lots may contain 0.03% silver or another stabilizer to limit decomposition
Inhalation: Remove person to fresh air immediately; keep at rest in a comfortable position for breathing; contact physician if symptoms develop (coughing, headache, dizziness, drowsiness)
Skin Contact: Remove contaminated clothing; wash affected skin with plenty of soap and water for 15 minutes; get medical attention if irritation occurs
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing; seek medical help for persistent irritation
Ingestion: Rinse mouth; never give anything by mouth to an unconscious person; do not induce vomiting; get medical advice immediately
Most Important Symptoms/Effects: Central nervous system depression, liver and kidney impairment, confusion, nausea, diarrhea, respiratory distress
Flammability: Not highly flammable, but can emit toxic fumes when heated
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray
Unsuitable Media: Do not use a direct water jet; may spread spilled material
Specific Hazards During Fire: Gas releases of phosgene, hydrogen chloride, and carbon monoxide possible
Special Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective gear
Hazardous Combustion Products: Phosgene, chlorine, hydrogen chloride, carbon oxides
Additional Information: Containers exposed to fire may burst or explode, move them from fire area if it can be done without risk
Personal Precautions: Evacuate non-essential personnel; ventilate area; avoid breathing vapor and skin contact; wear required PPE
Environmental Precautions: Prevent entry into sewers, soil, surface water, or drains
Methods for Cleanup: Use inert absorbent material (sand, earth, vermiculite); collect in sealed containers for disposal; clean spill site with water and detergent; avoid direct discharge into the environment
Additional Advice: Isolate area upwind, contain spill, dispose according to regulations
Cleanup Crew PPE: Chemical splash goggles, impervious gloves, apron, vapor respirator if necessary
Handling: Avoid inhaling vapors or mists; avoid contact with skin and eyes; only use in a chemical fume hood; keep container tightly closed; do not eat, drink, or smoke near product
Storage Conditions: Keep away from heat sources, open flames, and incompatibles (acids, alkali metals, oxidizers); store in cool, dry, well-ventilated area; protect from light by using amber glass containers; maintain temperature between 15-25°C
Incompatibilities: Alkali, strong bases, ammonia, oxidizing agents, acids, powdered metals
Special Storage Instructions: Label area clearly, check container integrity regularly, keep absorption materials on hand
Occupational Exposure Limits: OSHA TWA (ppm): 2 ppm (9.78 mg/m3), ACGIH TWA: 10 ppm (49 mg/m3)
Engineering Controls: Work in certified chemical hood, local exhaust recommended
Personal Protective Equipment: Splash goggles, lab coat, gloves (nitrile or neoprene), chemical-resistant apron; NIOSH/MSHA approved vapor respirator if limits exceeded or in confined spaces
Hygiene Measures: Do not handle without proper protective gear; wash hands after handling; wash contaminated clothing before reuse
Appearance: Colorless volatile liquid
Odor: Slightly sweet, ether-like odor
Odor Threshold: 85 ppm
Melting Point: -64°C (-83°F)
Boiling Point: 61.2°C (142°F)
Density: 1.49 g/cm3 at 20°C
Vapor Pressure: 160 mmHg at 20°C
pH: Not applicable (neutral liquid)
Solubility: Low solubility in water (approx. 8 g/L); miscible with most organic solvents
Flash Point: None (not classified as flammable)
Partition Coefficient (Log Kow): 1.97
Auto-ignition Temperature: Approx. 982°C
Decomposition Temperature: Decomposes above 400°C
Evaporation Rate: Higher than ether
Viscosity: Approx. 0.57 mPa·s at 25°C
Chemical Stability: Stable under recommended storage and handling; decomposition risk increases with light, moisture, and heat
Reactivity: Can react with strong bases, alkali metals, sodium, potassium, and oxidizers
Hazardous Reactions: Reacts with water or moist air slowly, can generate hydrochloric acid; forms phosgene when decomposed or combusted
Hazardous Decomposition Products: Hydrogen chloride, phosgene, chlorine, carbon monoxide, carbon dioxide
Conditions to Avoid: Prolonged exposure to high temperatures, sunlight, and incompatible chemicals
Incompatibilities: Alkalis, aluminum, potassium, sodium, magnesium, strong oxidizers and acids
Acute Toxicity: Oral LD50 (rat): 695 mg/kg; Inhalation LC50 (rat, 4h): 47700 mg/m3
Chronic Toxicity: Repeated exposure affects liver, kidneys, and central nervous system; may cause cancer in animals (IARC Group 2B: Possibly carcinogenic to humans)
Skin/Eye Irritation: Causes irritation with redness, itchiness, tearing
Sensitization: Not classed as a sensitizer
Mutagenicity: Mutagenic effects documented in some in vitro studies
Carcinogenicity: Classified as a possible human carcinogen (IARC 2B); ACGIH A3: Confirmed animal carcinogen
Reproductive Toxicity: Evidence of fetal toxicity in laboratory animals
Symptoms of Overexposure: Drowsiness, headache, nausea, dizziness, liver and kidney dysfunction, unconsciousness at high concentrations
Toxicity to Aquatic Life: LC50 (Fish, 96 hr): approx. 18-97 mg/L; EC50 (Daphnia, 48 hr): 28 mg/L
Persistence and Degradability: Not readily biodegradable; slowly degrades under sunlight and microorganisms
Bioaccumulative Potential: Moderate (Log Kow 1.97)
Mobility in Soil: High volatility, can easily evaporate to air; limited adsorption in soil
Other Adverse Effects: Ozone depleting substance; do not release to environment; report accidental releases as appropriate
Additional Information: Acts as a groundwater contaminant if spilled or leaked
Disposal Methods: Incinerate at a licensed chemical waste incinerator with afterburner and scrubber; do not pour into drains, sewers, or typical municipal waste systems
Contaminated Packaging: Rinse thoroughly with water, dispose as hazardous chemical waste
Special Instructions: Dispose of product and packaging in accordance with all federal, state, and local regulations
RCRA Status: Listed hazardous waste; EPA waste code U044 (for chloroform), treat deuterochloroform similarly
Precautions: Use appropriate PPE for handling hazardous waste, document disposal as required under applicable rules
UN Number: UN 1888
Proper Shipping Name: Chloroform-d (Deuterochloroform)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Labels Required: Toxic (6), Environmental Hazard
Marine Pollutant: Yes
Land, Air, and Sea Transport Rules: Must comply with DOT, IATA, IMDG, ADR regulations; use approved containers, declare quantity and hazard class on paperwork
Additional Transport Instructions: Protect from physical damage during transport, secure load, comply with local requirements for hazardous goods
US Regulations: Subject to OSHA Hazard Communication Standard; listed in SARA 302, 313 and CERCLA sections; regulated under Clean Air Act and Safe Drinking Water Act as a hazardous substance
Canadian Regulations: Listed on DSL/NDSL; controlled product under WHMIS (Class D-1A, D-2A)
EU Regulations: Covered by REACH and CLP regulations; required labeling for toxic, environmental hazard
International Inventories: Present on TSCA, EINECS/ELINCS, AICS, ENCS, and other national inventories
Other Regulations: California Proposition 65 (cancer warning); restrict use, report amounts as required by law
