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Product Name: Chloroform-D
Chemical Name: Deuterochloroform
CAS Number: 865-49-6
Manufacturer: Standard laboratory chemical suppliers
Recommended Use: NMR solvent, research applications
Emergency Telephone: Listed by supplier or national poison control center
Classification: Acute toxicity (oral, dermal, inhalation), Skin and eye irritant, Carcinogenicity, Mutagenicity, Reproductive toxicity
Signal Word: Danger
Hazard Statements: Harmful if swallowed or inhaled, Suspected of causing cancer, Causes skin and eye irritation, May damage organs through prolonged or repeated exposure
Pictograms: Skull and crossbones, Exclamation mark, Health hazard
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Symptoms: Dizziness, nausea, headache, liver and kidney damage if exposure is repeated or high
Target Organs: Liver, kidneys, central nervous system
Chemical Formula: CDCl₃
Common Name: Deuterochloroform, Chloroform-D
Synonyms: Chloroform-d1, Trichloromethane-d
Concentration: >99%
Impurities: May include trace standard chloroform, water < 0.02%
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, seek medical attention
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water for at least 15 minutes, get medical help
Inhalation: Move to fresh air immediately, keep breathing comfortably, provide oxygen if breathing is difficult, call medical services
Ingestion: Rinse mouth with water, do not induce vomiting, seek professional medical help immediately
Most Important Symptoms: Drowsiness, dizziness, confusion, respiratory depression, risk of liver and kidney damage
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam
Unsuitable Media: Do not use water jets
Hazardous Combustion Products: Phosgene, hydrogen chloride, carbon oxides
Protective Equipment: Firefighters should wear self-contained breathing apparatus (SCBA) and protective clothing
Special Precautions: Approach from upwind, contain runoff to prevent contamination of water sources, cool containers with water spray from a safe distance
Personal Precautions: Evacuate unnecessary personnel, ventilate area, avoid sources of ignition
Protective Equipment: Use chemical-resistant gloves, goggles, lab coat, suitable respirator
Environmental Precautions: Prevent from entering drains, sewers, or waterways, contain spill using inert absorbents
Cleanup Methods: Absorb with sand or vermiculite, collect in sealed container for proper disposal, decontaminate area with detergent and water to remove residues
Handling: Use in a chemical fume hood, avoid inhaling vapors or direct contact, keep away from sparks or flames, use non-sparking tools, never pipette by mouth
Storage: Store in tightly closed amber glass containers in a cool, dry, well-ventilated area, segregate from incompatible materials such as bases and oxidizers, label containers clearly, keep away from sunlight and sources of heat, ensure secondary containment to prevent leaks
Engineering Controls: Use only in a certified chemical fume hood, provide eyewash stations and safety showers, maintain adequate ventilation
Exposure Limits: OSHA PEL: 2 ppm TWA, ACGIH TLV: 10 ppm TWA
Personal Protective Equipment: Nitrile gloves, chemical splash goggles, lab coat, suitable respirator for high concentrations or poor ventilation
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing before leaving area, do not eat, drink, or smoke in work areas
Appearance: Clear, colorless liquid
Odor: Sweet, ether-like
Odor Threshold: 80–130 ppm
pH: Not applicable
Melting Point: -63°C
Boiling Point: 61°C
Flash Point: Not flammable under typical laboratory conditions
Evaporation Rate: Rapid
Flammability: Not classified as flammable but can release toxic gases if involved in fire
Vapor Pressure: 197 mbar at 20°C
Vapor Density: 4.12 (air = 1)
Relative Density: 1.49 (water = 1)
Solubility: Miscible with most organic solvents, slightly soluble in water
Partition Coefficient (log Kow): 1.97
Auto-ignition Temperature: 982°C
Decomposition Temperature: Unstable in sunlight, decomposes producing phosgene
Chemical Stability: Stable under recommended storage, unstable exposed to light, heat, or bases
Reactivity: Reacts with strong bases, strong oxidizers, alkali metals
Hazardous Decomposition Products: Hydrogen chloride, carbon monoxide, carbon dioxide, phosgene gas
Polymerization: Does not polymerize
Conditions to Avoid: Sunlight, high temperatures, contact with open flame, incompatible materials such as alkalis and strong oxidizers
Acute Toxicity: Oral LD50 (rat): 695 mg/kg, Inhalation LC50 (rat, 4h): 47700 mg/m³
Skin Corrosion/Irritation: Causes moderate skin irritation
Serious Eye Damage/Irritation: Causes moderate eye irritation
Respiratory Sensitization: May cause respiratory tract irritation
Carcinogenicity: Listed by IARC as Group 2B (possibly carcinogenic to humans)
Reproductive Toxicity: Possible risk of harm to unborn child
Repeated Dose Toxicity: Chronic liver and kidney damage reported in animal studies
Symptoms Related to Exposure: Nausea, headache, fatigue, central nervous depression, risk of unconsciousness with high levels
Toxicity to Aquatic Life: LC50 (fish, 96h): 18– 44 mg/L, toxic to aquatic organisms
Persistence and Degradability: Moderate persistence, degrades slowly in soil and water
Bioaccumulative Potential: Low potential for bioaccumulation
Mobility in Soil: Leaches into groundwater, moderate mobility
Other Adverse Effects: Ozone depletion potential, contributes to atmospheric pollution
Waste Treatment Methods: Incinerate in chemical incinerator equipped with afterburner and scrubber, must follow federal, state, and local regulations
Container Disposal: Rinse containers three times with suitable solvent and render them unusable, dispose of at licensed hazardous waste site
Avoid Release: Do not allow material to reach soil, sewers, or waterways
UN Number: UN 1888
Proper Shipping Name: Chloroform
Transport Hazard Class: 6.1 – Toxic substances
Packing Group: III
Labels: Toxic
Environmental Hazards: Not a marine pollutant (per international regulations), but harmful to aquatic life
Special Precautions: Handle inside secondary containment, ensure container integrity during transport, comply with local and international shipping laws
OSHA: Regulated as a hazardous substance, enforce strict workplace controls
SARA Title III: Listed in Section 313 (Toxic Chemical Release Inventory)
TSCA: Listed in Toxic Substances Control Act Inventory
REACH: Subject to restrictions in the European Union
WHMIS (Canada): Class D2A (Very toxic material causing other toxic effects)
Other Regulations: Covered under Clean Air Act for ozone-depleting substances, complies with local, state, and national chemical safety and environmental laws
Worker Protection: Employers must provide training and access to safety data, monitor exposure levels, maintain emergency response plans
