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Material Safety Data Sheet (MSDS) – Capsaicin

Identification

Product Name: Capsaicin
Chemical Formula: C18H27NO3
CAS Number: 404-86-4
Synonyms: 8-Methyl-N-vanillyl-6-nonenamide
Recommended Use: Chemical reagent, pharmaceutical intermediate, pesticide formulation
Manufacturer Details: Refer to product packaging for supplier information
Contact for Emergency: Call local poison control and emergency response hotlines

Hazard Identification

Classification: Acute toxicity (Oral, Inhalation, Dermal), Eye irritation, Skin irritation
GHS Label Elements: Signal word: Danger; Pictograms: Skull and crossbones, Exclamation mark
Hazard Statements: Toxic if swallowed; Causes skin and eye irritation; May cause respiratory irritation
Precautionary Statements: Avoid all contact; Wear protective gear; Wash hands thoroughly after handling; Use in well-ventilated spaces
Routes of Exposure: Inhalation, skin, eye, ingestion
Target organs: Respiratory system, skin, eyes

Composition / Information on Ingredients

Chemical Name: Capsaicin
Chemical Purity: 95% minimum
Impurities: Dihydrocapsaicin, Nordihydrocapsaicin (trace amounts)
Other Constituents: None declared beyond trace solvents

First Aid Measures

Eye Contact: Flush with water for at least 15 minutes; seek medical attention if irritation persists
Skin Contact: Remove contaminated clothes, wash with soap and water; if irritation or burning continues, get medical help
Inhalation: Remove to fresh air, seek medical attention if breathing remains difficult
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical attention
Most acute symptoms: Burning pain, redness, coughing, watery eyes, trouble breathing

Fire-Fighting Measures

Suitable Extinguishing Media: Use alcohol-resistant foam, dry chemical, or carbon dioxide
Specific Hazards: Vapors may cause respiratory irritation; may emit toxic fumes under fire (nitrogen oxides, carbon monoxide)
Special Firefighting Equipment: Full protective suit, self-contained breathing apparatus
Firefighting Guidance: Avoid direct contact, move containers from fire area if safe, cool with water spray

Accidental Release Measures

Personal Precautions: Evacuate area, ventilate, avoid breathing dust or fumes, wear gloves and eye protection
Environmental Precautions: Prevent runoff from entering waterways or soil
Spill Cleanup: Use absorbent material, collect for proper disposal, wash area with soap and water

Handling and Storage

Handling: Keep away from heat, open flame, and incompatible materials; avoid dust generation; avoid contact with skin and eyes; wash hands thoroughly
Storage Conditions: Store in a cool, dry, well-ventilated location; keep container tightly closed; segregate from oxidizers and strong bases

Exposure Controls and Personal Protection

Engineering Controls: Mechanical ventilation, fume hood recommended; emergency eyewash stations
Personal Protective Equipment: Chemical-resistant gloves, safety goggles, lab coat, appropriate respirator for dust or vapor
Hygiene Measures: Wash hands and face after handling; no eating, drinking, or smoking in work area

Physical and Chemical Properties

Appearance: Off-white to pale yellow crystalline powder
Odor: Pungent, sharp
Melting Point: 62-65°C
Boiling Point: 210°C at 760 mmHg
Solubility: Slightly soluble in water, soluble in ethanol and organic solvents
Flash Point: 113°C
Vapor Pressure: 7.05×10⁻⁶ mmHg at 25°C
Density: 1.006 g/cm³
pH (1% solution): Not available

Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions
Conditions to Avoid: Heat, open flames, sunlight, incompatible chemicals
Incompatible Materials: Strong acids, strong bases, strong oxidizers
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides
Polymerization: Does not occur under normal handling

Toxicological Information

Acute Toxicity: LD50 (oral, rat): 47.2 mg/kg; LD50 (dermal, rabbit): 512 mg/kg
Potential Health Effects: Irritant to skin, eyes, mucous membranes, respiratory tract; severe burning sensations; cough, nausea, watery eyes; prolonged exposure can cause dermatitis and neurological symptoms
Chronic Effects: Prolonged skin exposure may lead to desensitization
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, or OSHA
Other Information: Sensitization possible on repeated contact

Ecological Information

Aquatic Toxicity: Harmful to aquatic organisms at high concentrations
Persistence/Degradability: Biodegradable over time, slow breakdown in water
Bioaccumulation: Low potential under normal environmental exposure
Mobility in Soil: Limited mobility due to low water solubility
Other Adverse Effects: Can irritate wildlife upon direct contact

Disposal Considerations

Waste Disposal Methods: Consign to hazardous waste disposal facility in accordance with local regulations
Container Disposal: Triple-rinse, puncture, and dispose of empty containers as hazardous waste
Precautions: Do not release into environment or water bodies; comply with all national and local regulations

Transport Information

UN Number: 2811
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (contains capsaicin)
Transport Hazard Class: 6.1 (Toxic Substances)
Packing Group: III
Special Precautions for Transport: Protect from physical damage and temperature extremes; label packages clearly
Marine Pollutant: Not classified
Transport Regulations: Subject to international and national transport rules

Regulatory Information

Inventory Status: TSCA listed, REACH registered
OSHA Hazards: Irritant, acute health hazard
SARA Title III: Not subject to reporting requirements
California Proposition 65: Not listed
Other Regulations: Observe all national and regional health, safety, and environmental regulations; consult official agencies for restrictions or additional requirements