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Product Name: Butylated Hydroxyanisole
Synonyms: BHA, 2(3)-tert-butyl-4-methoxyphenol
Recommended Use: Antioxidant in food, pharmaceuticals, cosmetics
CAS Number: 25013-16-5
Manufacturer/Supplier: Contact provides name, address, and emergency phone
Emergency Contact: Provided by supplier for chemical emergencies
Uses Advised Against: Not suitable for unapproved applications
Classification: Acute toxicity (oral, category 4), Eye irritation (category 2B), Skin irritation (category 2), Carcinogenicity (category 2 by IARC)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, suspected of causing cancer
Pictograms: Exclamation mark, Health hazard (GHS07, GHS08)
Precautionary Statements: Avoid breathing dust, wash hands after handling, wear protective gloves and eye protection, do not eat or drink while using
Other Hazards: Dust can cause mechanical irritation to mucous membranes
Chemical Name: Butylated Hydroxyanisole
Common Name: BHA
Concentration: ≥ 98% active ingredient
Impurities: Small percentages of isomeric BHA, trace byproducts of manufacture
CAS Number: 25013-16-5
Molecular Formula: C11H16O2
Molecular Weight: 180.25 g/mol
Inhalation: Move person to fresh air, keep at rest, seek medical advice if symptoms develop
Skin Contact: Remove contaminated clothing, rinse skin with soap and water for several minutes, get medical attention for irritation or allergic reaction
Eye Contact: Rinse cautiously with water for 15 minutes, remove contact lenses if present and easy, continue rinsing, seek medical attention for persistent irritation
Ingestion: Rinse mouth, do not induce vomiting, give water to drink if conscious, seek immediate medical help
Most Important Symptoms: Redness, dryness, itching and stinging of skin and eyes, possible gastrointestinal discomfort after ingestion
Advice for Medical Responders: Provide symptomatic and supportive care, monitor airway and breathing
Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide
Unsuitable Extinguishing Media: Avoid high-pressure water jets that may spread burning material
Fire Hazards: Material is combustible, may emit toxic fumes of carbon monoxide, carbon dioxide, and phenolic compounds on thermal decomposition
Special Protective Equipment: Full protective gear including self-contained breathing apparatus
Fire Fighting Procedures: Fight fire from uphill location, avoid inhaling fumes, use proper ventilation, keep containers cool with water spray where possible
Hazardous Combustion Products: Smoke containing carbon oxides, other irritating or toxic vapors
Personal Precautions: Evacuate area, use protective clothing, avoid breathing dust, prevent contact with skin and eyes
Emergency Procedures: Ventilate area, isolate spill from ignition sources, restrict access
Environmental Precautions: Prevent entry into waterways, drains, or soil
Containment Methods: Sweep up and place in suitable labeled container, avoid dust generation
Clean-up Procedures: Wash spill site after pick-up, dispose of collected material in accordance with national/local regulations
Handling: Work in well-ventilated area, minimize dust and airborne particles, avoid sources of ignition, wear gloves and eye protection, practice good industrial hygiene
Storage Conditions: Store in tightly closed original container, in a cool, dry, well-ventilated location, away from direct sunlight, heat, and oxidizing materials
Incompatibilities: Keep away from strong acids, strong oxidizers, and bases
Specific End Uses: Use only for approved food, pharmaceutical, or cosmetic applications as per local regulations, follow label instructions
Occupational Exposure Limits: No OSHA PEL or ACGIH TLV established; minimize exposure by dust control
Engineering Controls: Local exhaust and general ventilation to minimize dust
Personal Protective Equipment: Protective gloves (nitrile or rubber), safety goggles, lab coat or apron, dust respirator (N95 or higher) if dust exceeds exposure threshold
Environmental Exposure Controls: Use closed systems, prevent release into environment, use containment during bulk handling
Appearance: White to yellowish crystalline powder
Odor: Mild, phenolic
Boiling Point: 264°C
Melting Point: 48 – 63°C
Flash Point: 120°C (closed cup)
Explosive Limits: No data
Solubility: Insoluble in water, soluble in fats, oils, alcohol, ether
Vapor Pressure: Negligible at room temperature
Density: 1.038 g/cm³
pH: Not applicable (insoluble in water)
Partition Coefficient: log Kow ~ 3.0
Chemical Stability: Stable under normal storage and handling
Thermal Decomposition: Yields toxic fumes of carbon oxides
Hazardous Reactions: Reacts violently with strong oxidizers, acids, and bases
Conditions to Avoid: High temperatures, sparks, open flame, incompatible substances
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, irritating phenolic vapors
Acute Oral Toxicity (LD50, rat): ~2,000 mg/kg
Skin Irritation: May cause irritation and sensitization after prolonged or repeated exposure
Eye Irritation: Causes redness and discomfort
Inhalation Toxicity: Dust may cause respiratory tract irritation
Carcinogenicity: IARC classified as possible human carcinogen (Group 2B)
Chronic Effects: Repeated dose may affect liver and kidneys in animal studies
Mutagenicity/Teratogenicity: Not considered mutagenic under standard test conditions; no major evidence for teratogenicity at permitted levels
Additional Information: Prolonged high-dose administration may cause organ weight changes in laboratory animals
Ecotoxicity: Toxic in high concentrations to aquatic life, LC50 (96h, fish): >1 mg/L, sensitive to invertebrates
Persistence and Degradability: Not readily biodegradable, potential for persistence in environment
Bioaccumulation Potential: Evidence for moderate bioaccumulation (log Kow ~3)
Mobility in Soil: Low mobility due to poor water solubility
Other Adverse Effects: Accumulation possible with repetitive contamination, risk to soil and water ecology with improper disposal
Waste Disposal: Dispose in accordance with local, national, and international regulations for hazardous waste
Methods of Disposal: Incinerate in approved facility, do not dispose to landfill, avoid release to drains
Container Disposal: Decontaminate container, triple rinse, dispose as hazardous solid waste
Special Precautions: Consult authorized waste contractor, keep out of municipal waste streams
UN Number: Not regulated for ground or air transport
Proper Shipping Name: Butylated Hydroxyanisole
Transport Hazard Class: Not classified as dangerous goods
Packing Group: Not assigned
Special Transport Precautions: Protect from excessive heat and direct sunlight, avoid generating dust during transfer
US (TSCA): Listed
EU (EINECS/REACH): Listed; subject to regulation for use in food, cosmetics, and pharmaceuticals
Canada (DSL): Listed
Japan (ENCS): Listed
China (IECSC): Listed
Restrictions: Use levels and applications regulated in food and drugs (FDA, EU Directives, etc.)
Labeling Requirements: Follows GHS for chemical labeling, hazard communication required in workplace environments
