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Product Name: Bromophenol Blue
Chemical Name: 3',3'',5',5''-Tetrabromophenolsulfonphthalein
Synonyms: Bromophenol sulfone phthalein, BPB
CAS Number: 115-39-9
Molecular Formula: C19H10Br4O5S
Recommended Use: Biochemical research, pH indicator, laboratory reagent
Supplier Information: Available from major laboratory chemical suppliers, typically through their chemical safety contact numbers and addresses
Emergency Contact: Reach out to supplier-specific emergency lines, hospital poison units, or local authorities as listed on the label
GHS Classification: Acute Toxicity-Oral (Category 5), Skin Irritation (Category 3), Eye Irritation (Category 2B)
Pictograms: Exclamation mark (as per GHS labelling)
Signal Word: Warning
Hazard Statements: May cause mild skin irritation, causes mild eye irritation, may be harmful if swallowed, causes respiratory tract irritation if dust is inhaled
Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, use protective gloves, eye protection, and face protection
Chemical Identity: Bromophenol Blue
Concentration: 99% or higher (for analytical grade); impurities less than 1%
Hazardous Components: None present above reporting thresholds in pure product
Impurities: Inorganic salts or organic process byproducts possible at trace levels
Inhalation: Move exposed individual to fresh air immediately, keep at rest and monitor for respiratory distress, medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, flush skin with copious water and mild soap, seek medical advice if irritation persists
Eye Contact: Rinse eyes with flowing water for 15 minutes while holding eyelids apart, remove contact lenses if present, medical attention if discomfort continues
Ingestion: Rinse mouth thoroughly, provide water if conscious, do not induce vomiting, call medical personnel right away
Acute/Delayed Symptoms: Watch for irritation, allergic reactions, or trouble breathing; act promptly and consult clinicians for further assessment
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam fire extinguishers for controlling flames
Specific Hazards: Product decomposition generates hazardous fumes, including hydrogen bromide, sulfur oxides, and carbon oxides
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear to avoid exposure to gases/fumes
Additional Information: Cool containers with water mist to prevent pressure build-up or explosion; avoid allowing runoff to enter drains
Personal Precautions: Wear dust mask, gloves, goggles, and protective clothing to avoid direct contact
Environmental Precautions: Prevent further leakage or spillage if safe to do so; keep out of drains, surface, and ground water
Methods for Clean-Up: Sweep up and place in properly labeled, sealed containers for disposal. Neutralize residue and use a damp cloth to clean affected surfaces. Ventilate area thoroughly after cleanup
Reference to Other Sections: Review exposure control, personal protection, and disposal sections for protective methods and disposal guidance
Handling: Use in ventilated areas, limit dust generation, avoid direct skin or eye contact, keep away from strong acids and oxidizers, follow established laboratory hygiene practices
Storage: Store in tightly closed containers, away from light, moisture, and incompatible materials; keep at ambient room temperature (<25°C) in a dry, well-ventilated location; ensure containers are clearly labeled and protected from physical damage
Incompatibilities: Avoid storing near strong bases, oxidizing agents, or reducing agents
Exposure Limits: No exposure limits set by OSHA, ACGIH, or NIOSH for Bromophenol Blue
Engineering Controls: Work in chemical fume hood if dust is generated; use local exhaust for large-scale processing
Personal Protective Equipment: Wear gloves resistant to chemicals (nitrile or equivalent), chemical splash goggles, laboratory coats, and dust masks or respirators when needed
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing, avoid eating or drinking in workspace, keep eyewash and safety shower accessible in laboratory
Appearance: Deep blue, purple, or reddish powder
Odor: Odorless
pH (as solution): 3.0 - 4.5 (at 1% solution)
Melting Point: 273–279°C (decomposition starts before complete melting)
Boiling Point: Not determined; decomposes on strong heating before boiling
Solubility: Low water solubility, soluble in alcohol and certain organic solvents
Specific Gravity: 1.67 (approximate)
Vapor Pressure: Not applicable at room temperature
Partition Coefficient (log Pow): Not available
Flash Point: Not flammable under standard laboratory conditions
Other Properties: Stable as a dry solid; color changes from yellow (acidic) to blue (basic) in solution as a function of pH
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not reactive under normal handling and storage as specified
Conditions to Avoid: Strong heat, contact with acids and bases, light, or moisture exposure
Incompatible Materials: Strong oxidizing agents, reducing agents, strong acids, and strong bases
Hazardous Decomposition Products: Hydrogen bromide, sulfur oxides, carbon oxides under fire conditions or strong thermal decomposition
Hazardous Reactions: Will not occur under most anticipated laboratory or industrial conditions
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Acute Toxicity: Low acute toxicity based on animal studies; oral LD50 (rat) estimated above 5000 mg/kg
Chronic Effects: No data available on long-term human exposure; no evidence of carcinogenicity, mutagenicity, or reproductive toxicity in available literature
Symptoms: Skin and eye irritation, possible gastrointestinal discomfort if ingested, respiratory irritation if dust is inhaled
Target Organs: Eyes, skin, respiratory tract
Sensitization: No sensitization reactions reported in standard studies
Further Data: Regular exposure assessments should be performed for laboratory and industrial staff working with the powder or solutions
Aquatic Toxicity: Not classified as acutely toxic to aquatic organisms; limited biodegradability in standard aquatic tests
Persistence and Degradability: Likely persistent in soil and sediment; slow biodegradation in aquatic environments
Bioaccumulation: No evidence of significant bioaccumulation; studies show low bioconcentration potential
Mobility: May migrate in water systems if released; binds moderately to soils and sediments
Other Adverse Effects: Product components do not contain ozone-depleting substances or persistent organic pollutants as defined by international conventions
Waste Disposal Methods: Collect any spills and waste in tightly sealed containers, label for hazardous chemical disposal, send to approved chemical treatment or incineration facility
Contaminated Packaging: Rinse containers, minimize residue, and follow hazardous waste regulations for disposal of packaging
Sewage Disposal Restrictions: Do not release into sewers, drains, or natural waterways
Disposal Guidance: Consult local, regional, and national regulations for proper disposal procedures; engage licensed hazardous waste handlers where required
UN Number: Not classified as dangerous goods for transport
UN Proper Shipping Name: Not regulated
Transport Hazard Classes: None
Packaging Group: None assigned
Environmental Hazards: Not identified as marine pollutant
Special Precautions: Avoid extreme heat and direct sunlight during transport; store upright and secure containers against breakage or leakage
DOT/IATA/IMDG Guidelines: Non-hazardous for air, land, and sea transport under current hazardous chemical classifications
OSHA Hazards: Target organ effects possible, skin and eye irritant
SARA 302/304/311/312/313: Not listed or regulated
TSCA Status: Listed on United States Toxic Substances Control Act inventory
REACH Status (EU): Registered/Pre-registered for chemical safety assessment requirements
WHMIS Classification (Canada): D2B: Toxic Material Causing Other Toxic Effects (based on irritation)
California Proposition 65: Not included in Proposition 65 list of chemicals known to cause cancer, birth defects, or other reproductive harm
International Inventories: Included in chemical substance inventories for main regulatory regions (Australia AICS, Canada DSL, EU EINECS/ELINCS, Japan ENCS, etc.)
Other Regulatory Requests: Standard laboratory safety and environmental practices are mandatory; consult national authorities for up-to-date compliance obligations
