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Product Name: Bromobutane
Chemical Name: 1-Bromobutane
Synonyms: n-Butyl bromide, Butane, 1-bromo-
CAS Number: 109-65-9
EC Number: 203-688-6
Molecular Formula: C4H9Br
Recommended Use: Laboratory chemicals, synthesis intermediate
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Emergency Overview: Colorless liquid, strong odor, potentially hazardous by inhalation, skin contact, or ingestion
Hazard Classification: Flammable liquid, acute toxicity (oral, inhalation, dermal), skin and eye irritant, possible reproductive toxin
Hazard Pictograms: Flame, exclamation mark, health hazard symbol
Signal Word: Danger
Hazard Statements: Causes skin irritation, serious eye irritation, harm if swallowed or inhaled, suspected of damaging fertility or the unborn child, may cause drowsiness or dizziness, highly flammable liquid and vapor
Precautionary Statements: Avoid breathing fumes/vapors, wash exposed skin thoroughly after handling, use explosion-proof equipment, protect from static discharge, store in a well-ventilated area, keep away from ignition sources
Routes of Exposure: Inhalation, skin contact, ingestion, accidental eye contact
Target Organs: Central nervous system, liver, kidneys, mucous membranes
Chemical Name: 1-Bromobutane
CAS No.: 109-65-9
Concentration: >99%
Impurities: May contain trace halogenated butanes, trace water
Additional Components: None reported
General Advice: Seek immediate medical attention if feeling unwell; show this safety sheet to health professionals.
Inhalation: Move person to fresh air, keep at rest, maintain an open airway, seek medical care if symptoms linger.
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, seek medical advice if irritation develops or persists.
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present, continue rinsing, consult a medical professional.
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical assistance.
Most Important Symptoms/Effects: Respiratory irritation, dizziness, headaches, nausea, skin redness or blistering, eye irritation.
Notes for Physician: Treat symptomatically, monitor respiratory and cardiac function, support vital functions.
Suitable Extinguishing Media: Dry chemical, alcohol-resistant foam, carbon dioxide; water may be ineffective but can cool containers.
Unsuitable Extinguishing Media: Direct stream of water on burning liquid.
Specific Hazards: Vapors may form explosive mixtures with air, toxic gases (hydrogen bromide, carbon monoxide) released if burned.
Special Protective Equipment: Self-contained breathing apparatus, full protective gear.
Firefighting Instructions: Remove containers if safe to do so, stay upwind, keep fire-exposed containers cool, prevent runoff from entering drains.
Hazardous Combustion Products: Hydrogen bromide, carbon dioxide, carbon monoxide, small amounts of other toxic vapors.
Personal Precautions: Evacuate area, ensure adequate ventilation, eliminate ignition sources, wear appropriate PPE.
Environmental Precautions: Prevent leakage or spillage into drains, watercourses, and soil.
Containment: Stop leak if safe, dike for later disposal with non-combustible absorbent materials.
Cleanup Methods: Soak up with sand, vermiculite, or earth, collect spillage in containers for disposal, flush area with water afterward.
Other Information: Report releases to local health, fire, and environmental authorities as required.
Handling: Avoid inhalation, skin and eye contact, do not breathe vapors, use in well-ventilated places, ground containers and transfer equipment.
Storage: Keep tightly closed, store in cool, dry, well-ventilated area away from incompatible substances, segregate from oxidizing agents and acids.
Other Precautions: Use non-sparking tools, monitor containers for integrity, label storage clearly, limit access to trained personnel.
Occupational Exposure Limits: Not established specifically; control exposures well below levels causing symptoms.
Engineering Controls: Local exhaust ventilation, eye wash stations, safety showers.
Personal Protective Equipment: Chemical-resistant gloves (nitrile), safety goggles, flame-retardant lab coats or coveralls, face shields when splashing possible.
Respiratory Protection: Suitable organic vapor respirators if controls are inadequate.
Hygiene Measures: Wash hands thoroughly after use, do not eat or drink near the material, remove contaminated clothing immediately.
Environmental Controls: Avoid release to the environment, use containment trays if possible.
Appearance: Clear, colorless liquid
Odor: Strong, sweetish
Odor Threshold: Not available
pH: Not applicable
Melting Point/Freezing Point: -112°C
Boiling Point: 101°C
Flash Point: 24°C (closed cup)
Evaporation Rate: Not measured
Flammability: High
Upper/Lower Flammability or Explosive Limits: Lower 1.6%, Upper 8.0% (v/v)
Vapor Pressure: 21 hPa at 20°C
Vapor Density: 4.9 (air = 1)
Density: 1.27 g/cm³
Solubility: Insoluble in water, miscible with alcohol, ether, chloroform
Partition Coefficient (log Kow): 2.4
Auto-ignition Temperature: 360°C
Decomposition Temperature: Not determined
Viscosity: Not determined
Chemical Stability: Stable under recommended storage conditions.
Possibility of Hazardous Reactions: Excessive heat or contact with alkali metals, strong bases, strong oxidizers may cause violent reactions.
Conditions to Avoid: Heat, sparks, flames, sources of ignition, moisture.
Incompatible Materials: Strong oxidizing agents, alkali metals, strong acids and bases.
Hazardous Decomposition Products: Hydrogen bromide gas, carbon oxides, irritating fumes.
Acute Toxicity: Oral LD50 (rat): 2000 mg/kg. Inhalation LC50 not precisely measured, but harmful at moderate concentrations.
Routes of Exposure: Skin contact, eye contact, inhalation, ingestion.
Symptoms: Dizziness, fatigue, headache, respiratory tract irritation, nausea, vomiting, central nervous system depression.
Skin Corrosion/Irritation: Causes irritation on prolonged or repeated exposure.
Serious Eye Damage/Irritation: May cause pain, redness, and blurred vision.
Respiratory Sensitization: Not classified — repeated exposure may aggravate asthma or existing respiratory disorders.
Carcinogenicity: Not listed as a carcinogen by NTP, IARC, or OSHA.
Reproductive Toxicity: Studies indicate possible developmental toxicity in high doses in animals.
Chronic Effects: Prolonged exposure may cause damage to the nervous system and risk of organ toxicity.
Ecotoxicity: Harmful to aquatic life, particularly fish and invertebrates, due to toxicity and persistence.
Persistence and Degradability: Not readily biodegradable, potentially persistent in soil and water.
Bioaccumulative Potential: Moderate, due to log Kow value; may accumulate in aquatic organisms over time.
Mobility in Soil: Low to moderate, volatile compound; potential for vapor phase migration.
Other Adverse Effects: May contribute to ozone depletion in the upper atmosphere, avoid uncontrolled environmental releases.
Waste Treatment Methods: Collect and arrange for disposal at a licensed hazardous waste facility or incineration under controlled conditions.
Contaminated Packaging: Rinse containers to remove all residue, puncture to prevent reuse, send as hazardous waste.
Special Precautions: Do not dispose of via household waste, minimize discharge into sewers or the environment, comply with all local, regional, and national regulations regarding chemical disposal.
UN Number: 1126
Proper Shipping Name: N-Butyl Bromide
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: II
Labels: Flammable liquid
Marine Pollutant: Yes
Special Transport Precautions: Secure tightly, segregate from incompatible goods, ensure containers are clearly labeled and protected from damage, follow International Maritime Dangerous Goods (IMDG) and International Air Transport Association (IATA) guidelines.
Regulations: Subject to chemical safety legislation under OSHA Hazard Communication Standard, EPA Clean Water Act section 311, CERCLA hazardous substance list.
Inventory Status: Listed under TSCA, EINECS, DSL/NDSL and AICS inventories.
Restrictions: Potential sales/use restrictions in some jurisdictions due to toxicity and flammability.
Workplace Labeling: Labels must clearly state hazard classification, PPE, and emergency procedures.
Other Information: Refer to local, regional, and international guidelines for workplace and environmental safety regulation updates.
