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Product Name: Bacillus Licheniformis Protease
Synonyms: Alkaline Subtilisin Protease, Bacterial Protease
Recommended Use: Enzyme additive for detergents, textile processing, leather treatment, food processing, waste management
Supplier Details: Manufacturer’s name, address, and emergency contact number
CAS Number: 9014-01-1
EC Number: 232-752-2
Product Description: Powder or granule containing active enzyme derived from Bacillus licheniformis fermentation broth; off-white to light yellow in color, with slight characteristic odor.
GHS Classification: Respiratory Sensitizer (Category 1), Eye Irritant (Category 2), Skin Sensitizer (Category 1)
Hazard Statements: May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause skin and eye irritation. May cause allergic skin reactions.
Signal Word: Danger
Pictograms: Health hazard, Exclamation mark
Precautionary Statements: Avoid breathing dust or aerosols. Use protective eyewear, gloves, and mask. Wash hands thoroughly after handling.
Emergency Overview: Enzyme dust can provoke respiratory allergic reactions with repeated or prolonged exposure; irritation to eyes and skin possible on contact.
Component: Bacillus Licheniformis Protease
Chemical Formula: Protein hydrolyzing enzyme (complex protein and carbohydrates)
Concentration: Active enzyme content ranges 2%–10% w/w; rest is stabilizer, carriers (sodium chloride, dextrin, cellulose, or similar)
Impurities: Byproducts from fermentation such as peptides, residual medium components
Enzyme Activity: 100,000–500,000 U/g, depending on process
Inactive Ingredients: Dust-reducing agents, water of hydration
Toxic Impurities: None present in significant quantities as per product specifications
Inhalation: Move person to fresh air. Keep warm and at rest. Seek medical advice if symptoms persist such as wheezing, coughing, shortness of breath.
Skin Contact: Remove contaminated clothing. Wash skin with copious amounts of soap and water. If irritation or redness develops, consult physician.
Eye Contact: Rinse eyes immediately and thoroughly with plenty of water for at least 15 minutes. Remove contact lenses if present and easy to do so. Seek medical attention for persistent pain or redness.
Ingestion: Rinse mouth with water. Drink water to dilute. Do not induce vomiting unless directed by medical personnel. Get medical help for any unusual symptoms.
Protection for First Aiders: Wear gloves and mask to avoid secondary exposure to dust or powder during aid.
Suitable Extinguishing Media: Water spray, foam, dry powder, carbon dioxide
Unsuitable Media: None known for this enzyme
Specific Hazards: Proteinaceous powder can release irritating or toxic fumes (mainly carbon oxides, nitrogen oxides, ammonia) under fire conditions
Protective Equipment: Self-contained breathing apparatus (SCBA), full protective clothing to prevent skin and respiratory exposure
Special Precautions: Cool containers with water if exposed to fire. Prevent run-off from entering watercourses.
Personal Precautions: Avoid creating airborne dust. Ventilate area. Wear particulate respirator, protective gloves, goggles, disposable coveralls.
Environmental Precautions: Prevent entry of significant quantities into surface drains, sewers, soil, or waterways.
Containment: Clean up spill promptly. Cover with damp inert absorbent material such as sawdust or sand, scoop into labelled containers for disposal.
Cleaning Methods: Wash affected area with copious amounts of water and detergent. Avoid dry sweeping—prefer vacuum equipment with HEPA filter.
Disposal: Collect residues in designated containers for disposal according to local regulations.
Precautionary Handling: Use only with adequate ventilation. Do not inhale dust or mist. Avoid direct contact with eyes, skin, and clothing. Wear recommended PPE (dust mask, goggles, gloves, lab coat).
Hygiene Practices: Wash thoroughly after handling. Do not eat, drink, or smoke while working. Remove contaminated clothing immediately.
Storage Conditions: Store in original tightly sealed containers, in cool, dry, well-ventilated place away from incompatible materials and foodstuffs.
Temperature Range: Store between 2–15°C for optimal stability; avoid freezing and overheating. Protect from moisture and direct sunlight.
Incompatibilities: Strong acids, alkalis, and oxidizers can denature product.
Packaging Materials: Use moisture-proof, robust packaging to avoid accidental release.
Occupational Exposure Limits: No official TLV for enzymes; manufacturer recommends exposure not exceed 60 ng/m3 for airborne proteases.
Engineering Controls: Local exhaust ventilation, closed handling systems, dust capture at points of use.
Personal Protective Equipment: NIOSH-approved particulate respirator (N95 or higher), chemical-resistant gloves (nitrile, latex), safety goggles, protective clothing with long sleeves.
Other Protection: Eye-wash station and safety shower in work area.
Monitoring: Routine air monitoring in production areas with regular medical surveillance for respiratory sensitization.
Appearance: Off-white to light yellow powder or granules
Odor: Mild, proteinaceous
Odor Threshold: Not established
pH (1% Solution): 7–10, alkaline
Melting Point / Freezing Point: Decomposes on heating above 60°C
Boiling Point: Not applicable (decomposes)
Flash Point: Not applicable
Flammability: Not classified as flammable; dust may form explosive mixtures with air under rare circumstances
Solubility: Soluble in water
Vapor Pressure: Not applicable
Relative Density: 0.8–1.2 g/cm3
Other Data: Bulk density, particle size distribution available on specification sheet.
Chemical Stability: Stable under normal conditions if kept dry and below 25°C
Instability: Sensitive to moisture, high temperature, and extreme pH
Reactivity: Inactive in strong acids, alkalis, or when exposed to oxidizing agents
Hazardous Reactions: Will not polymerize
Decomposition Products: Carbon dioxide, water vapor, oxides of nitrogen and sulfur, minor ammonia formation by protein breakdown
Conditions to Avoid: High humidity, direct exposure to light, heat, incompatible substances
Acute Toxicity: Low oral toxicity in animal studies; LD50 (oral, rat) >2000 mg/kg
Inhalation: Dust may cause allergic reactions in sensitized individuals even at low concentrations; symptoms may include wheezing, chest tightness, cough, rhinitis
Skin: Possible irritation or allergic dermal response; not considered corrosive or acutely toxic through skin
Eyes: Causes mild to moderate irritation
Chronic Effects: Sensitization by repeated exposure with risk of occupational asthma
Carcinogenicity/Mutagenicity: No evidence in standard screening assays
Reproductive Toxicity: No known reproductive hazards documented
Ecotoxicity: Practically non-toxic to aquatic life at concentrations used; mainly protein and biodegradable by nature
Persistence and Degradability: Rapidly biodegradable in water and soil, degraded by microbial action
Bioaccumulation: Highly unlikely, breaks down into amino acids and peptides
Mobility: Highly soluble, mobile in aquatic environments until degraded
Other Harmful Effects: No potential for ozone depletion, global warming, or photochemical smog noted
Waste Disposal Methods: Dispose of concentrated enzyme or contaminated packaging as non-hazardous industrial waste in accordance with regional, national, and local regulations; incinerate only in approved facilities
Unused Product: Dilute with excess water and treat as biodegradable organic waste
Contaminated Packaging: Triple rinse containers, then recycle or dispose as non-hazardous waste
Precautions: Avoid uncontrolled release to drains, surface water, or soil
Special Instructions: National or regional enzyme disposal protocols apply, consult local waste authorities for specific guidance
UN Number: Not classified as hazardous for transport
Transport Hazard Class: Non-hazardous
Packing Group: Not assigned
Special Precautions: Keep containers tightly sealed; transport in cool, dry conditions
Proper Shipping Name: Enzymatic preparation, non-hazardous
Labeling: Product labeling provides GHS hazard pictograms, signal words, and safety statements as required
Classification under Chemical Regulations: Non-hazardous under US OSHA, EU CLP, Canadian WHMIS for most workplace applications—subject to dust exposure regulations
Other Regulations: Subject to workplace air quality standards for enzyme dusts and respiratory allergens. Not listed as a controlled substance under major chemical safety conventions.
Occupational Limits: Regulatory bodies recommend exposure below threshold levels for biological enzymes.
Inventory Status: Listed or notified on TSCA, EINECS/ELINCS, AICS, DSL, and other relevant national inventories
Additional Information: Safety data reviewed by in-house health and safety professionals, updated periodically in keeping with changes to regulations and scientific understanding.
