© 2026 Nanjing Finechem Holdings Co., Ltd,
All Right Reserved
Product Name: Ascentis C18 HPLC Column
Product Number: Varies by specification (example: 581324-U, 581325-U, etc.)
Manufacturer: MilliporeSigma (division of Merck KGaA, Darmstadt, Germany)
Recommended Use: High Performance Liquid Chromatography (HPLC) for laboratory separation and analysis
Supplier Address: 3050 Spruce St, St. Louis, MO 63103, USA
Contact Information: Customer Service: +1-800-325-3010 / Emergency Phone: CHEMTREC +1-800-424-9300
GHS Classification: Not classified as a hazardous chemical product under GHS criteria
Label Elements: No pictogram, signal word, or hazard statements required
Physical Hazards: Contains stainless steel hardware; care needed to prevent cuts or punctures
Health Hazards: Silica-based C18 stationary phase poses minimal risk when housed in the column shell; dust exposure unlikely during intended use
Other Hazards: Spent columns may retain hazardous sample residues from previous analyses (organic solvents, biological samples, etc.)
Column Hardware: 316 or 304 stainless steel (CAS: 12597-68-1)
Stationary Phase Substance: Silica, surface modified with octadecyl (C18) groups (CAS: 7631-86-9 for silica)
Bonded Phase Content: Monofunctional and/or trifunctional C18 organosilane
Ingredient Percentage: Stainless steel ~90-98%; Silica/C18 ~2-10% (varies depending on packing type and pore volume)
Impurities: Contains no dangerous impurities at relevant concentrations
General Advice: Remove contaminated clothing and seek medical attention for persistent symptoms
Inhalation: Unlikely exposure; move to fresh air if dust from packing is released by column breakage
Skin Contact: Wash area with soap and water after direct contact with column bed material
Eye Contact: Rinse cautiously with water for at least 15 minutes following any exposure to column material; seek medical attention for irritation
Ingestion: Not a typical exposure route; if ingested, rinse mouth and obtain medical care
Suitable Extinguishing Media: Use media appropriate for surrounding fire: foam, CO₂, dry chemical, water spray
Unsuitable Media: None known
Special Hazards: Stainless steel shell can retain heat and may project if exposed to extremely high temperatures; thermal decomposition produces oxides of silicon and carbon from bonded phase
Protective Equipment: Firefighters should use self-contained breathing apparatus and full protective gear
Combustion Products: Carbon oxides, silicon oxides, metal oxides
Personal Precautions: Wear appropriate protective clothing, gloves, and eye protection
Environmental Measures: Prevent waste from entering drains or watercourses
Containment: Collect broken columns and spilled material using non-sparking tools; gather in a suitable container for proper disposal
Cleanup Methods: Sweep up and contain spilled packing material or residue; ventilate area if fine dust is present
Safe Handling: Avoid dropping or subjecting columns to extreme mechanical shock; minimize direct handling of exposed packing if column hardware is compromised
Technical Measures: Operate within recommended pressure and pH limits specified by manufacturer
Safe Storage Conditions: Store columns tightly capped in cool, dry, well-ventilated areas; avoid excessive heat, direct sunlight, and freezing; prevent contact with strong acids or bases
Incompatible Materials: Strong oxidizing agents; store away from acidic or basic vapors
Engineering Controls: Use in laboratory with local exhaust ventilation if unauthorized release occurs
Personal Protective Equipment: Wear safety goggles, laboratory gloves, and lab coat
Respiratory Protection: Not required under normal operation; if dust exposure risk arises (e.g., column packing exposed), use NIOSH-approved respirator
Exposure Limits: No occupational exposure limits apply to finished column; silica dust (if released) OSHA PEL: 6 mg/m³ (total dust)
Appearance: Stainless steel tube with end fittings, packed with white or off-white particulate material
Odor: Odorless
Melting Point: Stainless steel >1300°C; silica ~1700°C; not relevant to normal product use
Boiling Point: Not applicable
Solubility: Insoluble in water or solvents
Vapor Pressure: Not applicable
Density: Stainless steel hardware: ~8 g/cm³; silica bed: ~2 g/cm³
pH: Not applicable; surface C18 phase stable in pH 2-8 (varies)
Flash Point: Not flammable
Chemical Stability: Stable under recommended storage conditions
Reactivity: Not reactive with water or most solvents
Possible Hazards: Contact with strong acids or bases can degrade bonded phase and packing
Hazardous Reactions: No known hazardous polymerization
Decomposition Products: Thermal decomposition may produce silicon dioxide, carbon oxides
Acute Toxicity: No toxicity expected from column hardware or sealed stationary phase
Chronic Effects: Chronic inhalation or dermal exposure to silica dust may cause respiratory irritation or silicosis (exposure risk only if packing is released)
Routes of Exposure: Inhalation, skin, and eye exposure possible only in the event of shell breach
Known Carcinogenicity: IARC classifies respirable crystalline silica as carcinogenic, but column form eliminates exposure
Other Health Effects: No mutagenic, teratogenic, or reproductive effects expected
Aquatic Toxicity: Not expected to be hazardous to aquatic environments in column form; spilled silica can cause particulate load
Persistence/Degradability: Silica is highly stable and non-biodegradable; C18 alkyl groups degrade slowly
Mobility in Soil: Low, insoluble in water and not bioaccumulative
Other Adverse Effects: Large spills of packing material could create localized particulate hazards to soil or waterways
Disposal Methods: Dispose of as laboratory waste in accordance with local, state, and federal regulations
Product Disposal: Intact columns and spent material should be collected for professional chemical waste management; avoid landfill if possible
Contaminated Packaging: Triple rinse and dispose of as laboratory equipment; treat as hazardous if exposed to toxic analytes or solvents
Special Precautions: Label waste containers detailing prior use if column has been exposed to hazardous substances
UN Number: Not regulated under ADR/RID, IMDG or IATA for transport
Proper Shipping Name: Not regulated
Hazard Class: None
Packing Group: None
Special Transport Precautions: Protect from mechanical damage, moisture, and extreme temperatures during transport
Environmental Hazards: None known; verify status if column used with hazardous materials
TSCA: All ingredients listed or exempt
REACH Status: Not classified as a substance or mixture under REACH; contained articles not subject to registration
OSHA Status: Not hazardous as finished product
SARA Title III: Not subject to reporting under Sections 302, 304, 313
California Prop 65: Column as shipped does not contain listed substances; risk may arise if silica dust is generated
EU Hazard Code: Not classified
Other Requirements: Product intended for laboratory or professional use only; not for human or veterinary therapeutic use
