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Product Name: Arsenic (III) Oxide
Synonyms: Arsenous oxide, white arsenic, diarsenic trioxide
Chemical Formula: As2O3
CAS Number: 1327-53-3
Recommended Uses: Glass manufacturing, wood preservatives, pigments, pesticides, chemical research
Manufacturer/Supplier: See label or local distributor
Emergency Contact: Local poison control center, 24hr emergency hotline as provided on label
Classification: Acute toxicity (oral, inhalation, dermal) – Category 2, Carcinogenicity – Category 1A, Hazardous to Aquatic Environment – Chronic Category 1
Signal Word: Danger
Hazard Statements: Fatal if inhaled, swallowed, or absorbed through skin. Causes cancer. Causes damage to organs through prolonged or repeated exposure. Very toxic to aquatic life with long lasting effects.
Pictograms: Skull and crossbones, health hazard, environment
Health Effects: Irritation of respiratory tract, skin and eyes; symptoms of poisoning include nausea, vomiting, abdominal pain, and peripheral neuropathy
Routes of Exposure: Inhalation, skin absorption, ingestion
Target Organs: Liver, kidneys, skin, nervous system
Chronic Exposure Risks: Increased cancer risk (lung, skin), anemia, peripheral vascular disease
Chemical: Arsenic (III) Oxide
Common Name: White arsenic
CAS Number: 1327-53-3
Concentration: > 99%
Impurities: Trace metal contaminants (lead, antimony, iron in very low concentrations)
Inhalation: Remove person to fresh air. Seek medical attention immediately. Apply artificial respiration if breathing stops.
Skin Contact: Remove contaminated clothing. Rinse skin immediately with plenty of water for at least 15 minutes. Seek medical attention.
Eye Contact: Rinse thoroughly with water for at least 15 minutes, keeping eyelids open. Seek immediate medical assistance.
Ingestion: Do not induce vomiting. Rinse mouth with water. Seek emergency medical help immediately.
Acute Symptoms: Headache, confusion, convulsions, abdominal pain, diarrhea, vomiting, rapid heartbeat
Advice for Medical Staff: Treat as arsenic poisoning. Monitor kidney and liver function. Consider chelation therapy as directed by poison control professionals.
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam; do not use water directly on substance.
Specific Hazards: Decomposes on heating to produce highly toxic arsenic fumes and oxides.
Protective Equipment: Positive-pressure self-contained breathing apparatus, full protective gear including chemical-resistant suit.
Advice for Firefighters: Avoid inhalation of vapors and dust. Use water spray to keep containers cool but avoid direct water stream.
Hazardous Combustion Products: Arsenic oxides, toxic metal fumes
Personal Precautions: Wear lab coat, gloves, eye protection, and approved respirator. Keep unnecessary personnel away. Do not touch or walk through spilled material.
Environmental Precautions: Prevent entry into drains, sewers, and watercourses. Notify appropriate authorities if significant quantities enter environment.
Cleanup Method: For small spills, use HEPA-filter vacuum or wet method to avoid dust. For larger spills, use non-combustible absorbent material, then place in suitable closed container for disposal.
Decontamination: Wash contaminated area with soap and water. Ventilate area thoroughly.
Handling: Use only in a chemical fume hood or well-ventilated area. Avoid generating dust, breathing vapors, and contact with skin or clothing. Wash thoroughly after use.
Storage: Store in tightly closed, clearly labeled containers. Keep containers in a cool, dry, well-ventilated place, away from acids, strong oxidizers, and moisture. Restrict access to trained personnel only.
Incompatibilities: Reacts with acids, oxidizing agents, and strong bases.
Storage Temperature: Ambient, away from sources of ignition and incompatible substances.
Occupational Exposure Limits: OSHA PEL: 0.01 mg/m3 (as As), NIOSH REL: 0.002 mg/m3, ACGIH TLV: 0.01 mg/m3
Engineering Controls: Use local exhaust ventilation or chemical fume hood to reduce airborne levels below permissible limits.
Personal Protection: NIOSH-approved respirator, safety goggles, face shield, chemical-resistant gloves (nitrile, PVC), full-body covering, and lab apron.
Hygiene Measures: Do not eat, drink, or smoke during use. Wash hands before eating and after handling. Remove contaminated clothing and wash before reuse.
Appearance: White, crystalline powder
Odor: Odorless
Molecular Weight: 197.84 g/mol
Melting Point: 312 °C
Boiling Point: 465 °C (sublimes)
Solubility: Slightly soluble in cold water, more in hot water; soluble in acids, insoluble in alcohol
Vapor Pressure: 2.7 mm Hg at 312 °C
Density: 3.87 g/cm3
pH: 5.9 (0.1M aqueous solution)
Partition Coefficient (Log Kow): -2.2
Stability: Stable under recommended storage conditions in dry air.
Hazardous Reactions: Reacts violently with strong oxidizers, acids, and strong bases, producing toxic arsenic gases.
Conditions to Avoid: Moisture, exposure to air, contact with incompatible materials.
Decomposition Products: Arsenic oxides, toxic fumes
Polymerization: Will not occur
Acute Toxicity: Oral LD50 (rat): 15 mg/kg; Inhalation LC50 (rat, 1h): 30 mg/m3
Routes of Exposure: Ingestion, inhalation, dermal absorption
Symptoms: Severe headache, dizziness, abdominal pain, vomiting, diarrhea, confusion, shock, convulsions
Chronic Effects: Cancer (lung, skin, bladder), liver toxicity, peripheral neuropathy, anemia, skin changes (hyperkeratosis, pigmentation)
Carcinogenicity: Classified as known human carcinogen by IARC, NTP, OSHA
Mutagenicity: Evidence in test systems for genetic mutations
Developmental Toxicity: Possible fetal toxicity based on animal studies
Target Organ Toxicity: Liver, kidneys, skin, nerves, respiratory tract
Ecotoxicity: Highly toxic to aquatic organisms and plants; severe risk of bioaccumulation in aquatic food chains.
Persistence and Degradability: Does not degrade, remains stable in environment, can persist in groundwater and soil for decades.
Bioaccumulation Potential: High; accumulates in fish, higher trophic animals, and plants.
Mobility in Soil: Moderate; can migrate through groundwater especially in acidic soils.
Aquatic Toxicity Data: LC50 (fish, 96h): 0.77 mg/L. EC50 (daphnia, 48h): 0.54 mg/L
Hazard to Birds and Mammals: Documented mortality and reproductive toxicity, especially in aquatic systems.
Waste Treatment Methods: Collect residue and contaminated materials in sealed, labeled containers. Dispose of as hazardous waste according to federal, state, and local regulations.
DO NOT: Flush to sewer, landfill, or allow product to enter environment.
Recommended Disposal: Incineration in authorized hazardous waste facility or safe chemical stabilization/neutralization followed by disposal.
Contaminated Packaging: Treat containers as hazardous waste, decontaminate prior to recycling or disposal.
UN Number: UN 1557
Proper Shipping Name: Arsenic trioxide
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Environmental Hazards: Marine pollutant
Special Precautions: Ensure packaging integrity, proper labeling, no transport with food, feed, or incompatible chemicals
Transport Regulations: Subject to IATA, IMO, DOT, ADR, RID requirements
US Regulations: SARA 302 (Extremely Hazardous Substance), SARA 313, CERCLA, TSCA listed; OSHA regulated carcinogen.
EU Regulations: Classified as carcinogen and aquatic toxin by ECHA; subject to REACH registration.
Canada: WHMIS D1A/B, D2A; DSL listed.
Other International Standards: IARC Group 1 (Carcinogenic to humans), GHS classification aligns globally.
Labeling Requirements: Danger, toxic, keep away from children, handle only with proper PPE
Restrictions: Restricted for use except by certified professionals in permitted facilities
