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Product Name: Antibiotic Antimycotic Solution
Synonyms: Penicillin-Streptomycin-Amphotericin B Solution
Recommended Use: Cell culture additive, controls bacterial and fungal contamination
Manufacturer Name: Refer to supplier label
Emergency Phone Number: Refer to local poison center or supplier contact
Product Code: Refer to packaging or ordering information
Relevant Identified Uses: Intended for laboratory or research use, not for human or animal therapeutic use
GHS Classification: Skin sensitizer (Category 1), Eye irritant (Category 2A), Toxic to aquatic life
Hazard Statements: Causes skin irritation, causes serious eye irritation, may cause allergic skin reaction, toxic to aquatic life with long-lasting effects
Pictograms: Exclamation mark, Environment
Signal Word: Warning
Precautionary Statements: Avoid breathing vapors or spray, wear gloves and eye protection, wash hands thoroughly after handling, avoid release to environment
Medical Conditions Aggravated: Allergic disorders, pre-existing skin or eye conditions
Penicillin G: Approx. 10,000 units/mL
Streptomycin sulfate: Approx. 10 mg/mL
Amphotericin B: Approx. 25 µg/mL
Water for Injection/Buffer: Remainder
CAS Numbers: Penicillin G: 61-33-6; Streptomycin sulfate: 3810-74-0; Amphotericin B: 1397-89-3
Percentages: Each ingredient concentration listed above typically reflects complete product formulation
Inhalation: Move person to fresh air, seek medical attention if symptoms develop such as coughing, dizziness, or irritation
Skin Contact: Remove contaminated clothing, wash skin with plenty of soap and water, seek medical help if rash or irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing for at least 15 minutes, obtain medical attention
Ingestion: Rinse mouth with water, do not induce vomiting unless instructed by medical personnel, contact poison control or seek immediate medical attention
Most Important Symptoms and Effects: Allergic reaction, skin rash, respiratory irritation, eye discomfort, gastrointestinal distress
General Advice: Never give anything by mouth to an unconscious person, keep affected individual under observation, provide medical professionals with product information
Suitable Extinguishing Media: Use carbon dioxide, dry chemical powder, water spray, or appropriate foam
Unsuitable Extinguishing Media: Strong water jets may scatter material
Specific Hazards: May produce hazardous decomposition products such as carbon oxides, nitrogen oxides, sulfur oxides upon combustion
Protective Equipment: Firefighters should wear self-contained breathing apparatus, full protective gear to prevent contact with skin and eyes
Other Information: Move containers away from fire area if it can be done safely, use water spray to keep containers cool in the event of fire
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, other toxic fumes
Personal Precautions: Evacuate area, ventilate space, avoid breathing vapors or mist, prevent contact with skin and eyes
Protective Equipment: Use chemical-resistant gloves, appropriate goggles, lab coat, and if needed, respirator approved for chemical exposure
Environmental Precautions: Prevent product from entering drains, surface water, or soil
Method for Containment and Clean-Up: Absorb spill using inert material (e.g., sand, silica gel, vermiculite), place collected material in a suitable chemical waste container, wash area thoroughly with water and detergent
Disposal of Contaminated Material: Dispose of in accordance with local, regional, and national regulations
Safe Handling Practices: Work in a well-ventilated area, avoid inhalation or ingestion, avoid skin and eye contact, do not eat, drink, or smoke while handling
Equipment and Procedures: Wear protective gloves, goggles, lab coat, and proper footwear, ensure eye wash and safety shower are accessible
Storage Conditions: Store at 2–8°C (refrigerator), protect from light and freeze, keep container tightly closed, keep away from heat and incompatible substances
Special Precautions: Keep away from children, restrict access to trained personnel
Engineering Controls: Use in chemical fume hood or with local exhaust ventilation, keep containment in place to minimize exposure
Respiratory Protection: Use a properly fitted respirator if respiratory risk exists or if required by conditions
Hand Protection: Latex, nitrile, or rubber gloves recommended
Eye Protection: Chemical splash goggles
Skin and Body Protection: Lab coat, apron, closed-toed shoes recommended
Hygiene Measures: Do not touch face, wash hands thoroughly after handling, remove contaminated clothing and wash before reuse
Form: Liquid solution
Color: Clear to light yellow
Odor: Faint, medicinal
pH: Typically ranges from 6.0 to 8.0
Melting and Boiling Point: Not applicable (aqueous solution)
Flash Point: Not determined (non-flammable aqueous solution)
Solubility: Completely soluble in water
Vapor Density: Not determined
Relative Density: Slightly higher than water
Evaporation Rate: Similar to water
Chemical Stability: Stable under normal storage and handling conditions at recommended temperature
Incompatible Materials: Strong oxidizers, acids, heavy metals
Conditions to Avoid: Freezing, excessive heat, direct sunlight
Hazardous Decomposition Products: May form toxic compounds such as carbon monoxide, carbon dioxide, nitrogen oxides, and sulfur oxides at high temperatures
Reactivity: No dangerous reactions known under regular use
Polymerization: Will not occur under normal conditions
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Effects: May cause allergic reaction, irritation to eyes, skin, or respiratory system
Chronic Effects: Prolonged or repeated exposure can lead to sensitization, particularly in individuals with allergies to antibiotics or antifungals
Oral Toxicity: Low due to dilute solution, but ingestion should be avoided
Skin Sensitization: May induce allergic dermatitis in susceptible individuals
Carcinogenicity: Ingredients not listed as human carcinogens by IARC, NTP, or OSHA
Mutagenicity: Not classified as mutagenic under normal laboratory use
Reproductive Toxicity: Not classified, but use caution if pregnancy is suspected
Target Organs: Skin, eyes, respiratory system, allergic responses may involve immune system
Additional Information: Those with known allergies to penicillins or amphotericin B should avoid handling
Environmental Fate: Antibiotic and antifungal components can be toxic to aquatic organisms, potential impact on beneficial environmental microbes
Persistence and Degradability: Components may not degrade rapidly under natural conditions, can persist in water or soil
Bioaccumulation Potential: Expected to be low, but potential exists for effects in aquatic environments
Ecotoxicity: Risk of negative effects on aquatic plants, invertebrates, and microbial communities
Mobility in Soil: Solution readily disperses in water, potential for leaching into groundwater exists if released in large amounts
Precautions: Avoid release to the environment, follow responsible disposal recommendations
Waste Disposal Methods: Dispose of according to local, state, and federal regulations, do not pour into drains or water sources
Contaminated Packaging: Dispose of as hazardous chemical waste, rinse empty containers with water before disposal if allowed by regulations
Sewage Disposal: Do not release instructional laboratory waste into regular sewage systems
Safe Handling of Waste: Use gloves and personal protection when handling discarded material
Suggested Treatment: Incineration in an approved chemical waste facility or other approved method
UN Number: Not regulated for transportation
Proper Shipping Name: Not classified as hazardous for transport
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Avoid accidental release during transport, secure containers properly
Special Precautions for User: Keep container upright and sealed, avoid exposure to extremes of temperature during transport
TSCA Status: Antibiotic and antifungal components covered for research use only
SARA Title III: Not listed as hazardous under Sections 302, 313
OSHA Classification: Hazardous due to sensitization and irritation potential
WHMIS Classification (Canada): D2B (Toxic material causing other toxic effects)
Labeling Requirements: Contains penicillin, streptomycin, and amphotericin B, handle according to laboratory safety protocols
Other Specific Regulations: Follow all applicable local, regional, and national environmental and safety legislation relevant to chemical handling and use
