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Substance name: Anhydrous Brucine
Chemical formula: C23H26N2O4
Common uses: Laboratory research, alkaloid studies, poison research
Appearance: White or colorless crystalline solid
Odor: Mild, somewhat bitter
Synonyms: None in regular use, as brucine usually applies directly to this compound
Toxicity: Very high; oral ingestion can result in severe poisoning with symptoms similar to those of strychnine
Health hazards: Acute exposure may cause convulsions, respiratory failure, and death; chronic exposure is linked to lasting neurological effects
Routes of exposure: Inhalation, ingestion, skin absorption, and eye contact
Eye hazards: Dust can cause pain, irritation, and potential corneal damage
Environmental hazards: Highly toxic to aquatic life; bioaccumulates in certain species
Classifications: Accorded high toxicity by health and environmental agencies worldwide
Main ingredient: Brucine, nearly pure (CAS No. 357-57-3)
Impurities: Minor secondary plant alkaloids depending on source, but usually occurs highly purified in commercial and research grades
Inhalation: Move person to fresh air, provide artificial respiration if breathing stops, seek immediate medical attention
Skin contact: Remove contaminated clothing and rinse skin with running water for at least 15 minutes; avoid further exposure and consult a physician
Eye contact: Immediately flush eyes with water for an extended period; keep eyelids apart and seek urgent medical advice
Ingestion: Do not induce vomiting; rinse mouth if conscious and transport to emergency healthcare as rapid absorption increases risk of death
Suitable extinguishing media: Use carbon dioxide, dry powder, or alcohol-resistant foam
Hazardous combustion products: Nitrogen oxides, carbon oxides, and toxic fumes
Precautions: Wear self-contained breathing apparatus and protective clothing; approach from windward to reduce inhalation risks
Additional dangers: May emit corrosive vapors and rapidly intensify burns in fires involving other chemicals
Spill response: Evacuate area, ventilate, collect dust without creating aerosols, and dispose of immediately in accordance with hazardous waste regulations
Protective equipment: Nitrile gloves, lab coat, safety goggles, and respirator if airborne powder is present
Decontamination: Wash affected area with plenty of water and control runoff to prevent environmental release
Handling: Only work in ventilated fume hoods, avoid contact with skin and eyes, keep containers tightly sealed, and store away from food or drink
Hygiene: Prohibit eating, drinking, or smoking near the substance; enforced handwashing after use
Storage: Store at room temperature in a dry, well-ventilated area, away from incompatible compounds such as acids and strong oxidizers
Labeling: Clear labeling for high toxicity minimizes confusion during emergencies
Engineering controls: Laboratories need exhaust hoods and good airflow systems that minimize dust buildup
Personal Protective Equipment (PPE): Gloves, lab coats, chemical-grade goggles, and sometimes full-face respirators
Exposure limits: Not specifically regulated by OSHA or ACGIH but recommended to keep airborne concentrations as low as possible, since even trace amounts pose health risks
Physical state: Solid, crystalline
Color: White or slightly gray
Odor: Mild, bitter
Melting point: Roughly 178 - 180°C
Solubility: Soluble in alcohol and slightly in water
Boiling point: Decomposes before boiling
Other characteristics: Degrades in light and air, so best stored away from both
Chemical stability: Stable under normal storage conditions, but sensitive to light, acids, and oxidizers
Reactivity: Reacts with strong acids, alkalies, and oxidants
Hazardous decomposition products: Toxic nitrogen oxides and carbon monoxide released with heat or combustion
Incompatible materials: Avoid all sources of heat, sparks, mineral acids, and strong oxidants
Acute toxicity: LD50 in animals reported as extremely low; causes convulsions, CNS stimulation, and death from respiratory paralysis
Chronic risks: Surviving acute poisoning may lead to lasting neurological problems and muscle damage
Sensitization: Documented allergen with potential for severe reaction in some individuals
Carcinogenicity/mutagenicity: No direct evidence links brucine to cancer, but its structural similarity to strychnine and neurotoxicity increase overall risk
Typical symptoms: Tremors, hyperreflexia, severe agitation, labored breathing, muscle rigidity, and seizures
Toxicity to aquatic organisms: Highly damaging, particularly to fish and amphibians at low concentrations
Persistence: Does not readily break down in water or soil; introduces long-term risk to affected environments
Bioaccumulation: Certain species concentrate alkaloids in tissue, comprising food chain safety
Mobility: Moves in water and poses groundwater contamination risks
Hazardous waste: Treat as acutely hazardous; do not attempt landfill or drain disposal
Preferred method: Incinerate with chemical scrubbers or send to specialized chemical waste facilities
Legal requirements: Follow all local, regional, and national regulations for hazardous and toxic chemicals
Hazard class: Considered Category 6.1 Toxic Substances under international law
Packing group: High hazard, special packaging required to prevent rupture and minimize exposures
Transport description: Requires labeling, documentation, and tracking because emergency response teams need advance notice in case of accident
Status: Regulated as a toxic and hazardous chemical in almost all jurisdictions
Worker protections: Strict control on workplace exposure, reporting, and permissible quantity for use and storage
Import/export restrictions: Many countries ban or severely restrict non-research possession or transport
Reference frameworks: Included on lists governing hazardous chemical safety, such as the United Nations’ GHS and many national poison control registries
