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Product Name: Angiotensin-Converting Enzyme
Common Synonyms: ACE, Peptidyl-dipeptidase A
Chemical Family: Enzyme, Protein
Recommended Use: Laboratory reagent, diagnostic use
Supplier: Specify individual laboratory or supplier address and emergency contact information
Emergency Phone Number: Refer to regional poison control centers or relevant authority
CAS Number: 9015-82-1
UN Number: Not regulated for transport
EC Number: 232-722-1
Other Identifiers: Found in clinical and research settings
GHS Classification: Not classified as hazardous according to GHS criteria
Hazard Statements: May cause mild skin, eye, or respiratory irritation upon direct contact
Precautionary Statements: Avoid inhalation of powder or dust, prevent contact with skin and eyes, ensure use in ventilated area
Pictograms: None
Signal Word: None
Target Organs: None identified for routine laboratory exposure
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Chronic Effects: Not established for low-concentration use; unknown long-term risks
Chemical Name: Angiotensin-Converting Enzyme
Molecular Formula: Varies (proteinaceous mixture), typically C2929H4520N780O898S40 per literature
Concentration: Lab-grade: typically ≥90% pure
Impurities: Carrier proteins (if lyophilized), buffer salts, trace water
Physical State: Lyophilized powder or liquid solution
Lot-Specific Information: Refer to product label or certificate of analysis
Major Ingredient: Peptidyl-dipeptidase A
Inhalation: Move affected person to fresh air; seek medical attention if symptoms develop
Skin Contact: Wash with soap and plenty of water for at least 15 minutes; remove contaminated clothing
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes; consult a physician
Ingestion: Rinse mouth with water; never give anything by mouth to an unconscious person; seek medical attention
Symptoms to Expect: Mild respiratory, skin, or eye irritation
Notes to Physician: Symptomatic treatment only, no specific antidote known
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical, foam
Special Hazards Arising from Substance: Combustion may produce carbon oxides, nitrogen oxides, sulfur oxides
Protective Equipment: Firefighters should wear full protective clothing including self-contained breathing apparatus
Precautions: Keep containers cool with water spray to prevent overheating
Unusual Fire Hazards: Powdered protein dust can form explosive mixtures in air, handle accordingly
Personal Precautions: Evacuate unnecessary personnel; use personal protective equipment (lab coat, gloves, safety goggles)
Environmental Precautions: Avoid release into drains and aquatic environments
Clean Up Method: Sweep up gently to avoid creating dust, place in a sealed container for disposal
Decontamination: Wash area with water and detergent; ventilate the area
Special Equipment: Use HEPA-filtered vacuum for cleaning powder spills
Handling: Handle inside chemical fume hood or well-ventilated location; minimize dust generation; avoid contact with skin and eyes
Storage Conditions: Store in a tightly closed container, desiccated, at -20°C unless otherwise specified; protect from moisture and light
Compatibility: Keep away from acids, oxidizers
Hygiene Practices: Remove contaminated clothing before leaving work area; wash hands thoroughly after handling
Engineering Controls: Use inside certified fume hood; ensure adequate general ventilation
Personal Protective Equipment:
Appearance: White to off-white lyophilized powder or clear/colorless solution
Odor: None or mild protein odor
pH: Often supplied in formulation buffer (pH 7.0–8.0); product-dependent
Melting Point: Not applicable (denatures before melting)
Boiling Point: Not applicable (biological macromolecule)
Solubility: Soluble in water and aqueous buffers
Vapor Pressure: Not applicable
Relative Density: Not determined
Other Properties: Stable as directed under storage conditions; may degrade rapidly at room temperature or under extreme pH
Chemical Stability: Stable under recommended storage conditions
Incompatible Materials: Strong acids, alkalies, oxidizers
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides during combustion
Hazardous Reactions: None known under normal use
Polymerization: Will not occur
Conditions to Avoid: Temperature extremes, moisture, direct sunlight, strong mechanical agitation
Acute Toxicity: No acute toxicity data available for laboratory exposure
Routes of Exposure: Inhalation, skin, eyes, ingestion
Potential Effects: Short-term irritation of eyes, skin, or respiratory tract; may cause allergic reactions in sensitized individuals
Chronic Effects: No known long-term health effects, protein nature reduces systemic toxicity risk
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a carcinogen
Reproductive Toxicity: No evidence or studies available
Mutagenicity: No evidence or studies available
Ecotoxicity: Not expected to be harmful in small quantities typical of laboratory use
Bioaccumulation: Not expected, enzymatic proteins are biodegradable
Mobility in Soil: Rapidly degraded by soil microorganisms
Aquatic Toxicity: Minimal environmental hazard if disposed according to regulations
Other Adverse Effects: No chronic ecological effects known at laboratory concentrations
Waste Disposal Method: Collect solid or liquid waste into sealed, labeled containers
Regulatory Status: Not classified hazardous under most regional waste regulations
Sewage Disposal: Avoid disposal via sink or drain; handle according to local, regional, and national laws
Special Instructions: Consult environmental health and safety office before large-volume disposal
UN Number: Not regulated
Proper Shipping Name: Not assigned
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: None required
Special Transport Precautions: Ship as temperature-sensitive material with proper cushioning against breakage
DOT, IATA, IMDG: No special restrictions for laboratory-scale transportation
OSHA Status: Not listed as a hazardous chemical in laboratory settings
TSCA Inventory: Not applicable as an enzyme for research
SARA Title III: Not regulated
California Prop 65: Not listed
WHMIS Status: Not controlled
REACH Regulation: Exempt for research-use protein reagent
Labeling Requirements: Lab-specific, standard research reagent labeling
Other Regulations: Keep in compliance with institutional biosafety and chemical hygiene plans
