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Product Name: Amyloglucosidase
Synonyms: Glucoamylase, AMG
CAS Number: 9032-08-0
Recommended Use: Enzymatic hydrolysis of starch into glucose, common in food, beverage, and fermentation industries
Supplier Details: Manufacturer and distributor contact details included on packaging label
Emergency Contact: Local, regional, and national poison control centers and manufacturer’s emergency telephone number
Classification: Respiratory sensitizer (Category 1), Eye Irritation (Category 2A), Skin Sensitization (Category 1)
Signal Word: Warning
Hazard Statements: May cause allergy or asthma symptoms or breathing difficulties if inhaled; may cause eye irritation; may cause an allergic skin reaction
Precautionary Statements: Avoid inhalation of dust, use personal protection as specified; seek medical attention if exposed
Label Elements: Hazard pictograms, including exclamation mark and health hazard symbol
Other Hazards: Dust formation may irritate mucous membranes and trigger allergic responses across sensitive populations
Common Name: Amyloglucosidase
Chemical Identity: Enzyme preparation produced by Aspergillus niger or similar microorganisms
Concentration: Active enzyme content ranges typically between 10,000 – 350,000 U/g, commonly diluted with inert carriers such as maltodextrin or sodium chloride
Impurities: Trace fermentation byproducts, possible stabilizers or preservatives, proprietary excipients depending on formulation
Other Components: Food-grade stabilizers, buffer salts, minimal water content in liquid formats, negligible non-enzyme protein
Inhalation: Move to fresh air and keep at rest in a comfortable position; provide oxygen or artificial respiration if symptoms persist; seek medical advice if respiratory issues or allergic reactions develop
Eye Contact: Rinse the affected eye(s) with plenty of water for at least 15 minutes, holding eyelids open; remove contact lenses promptly if present and easy to do so; consult a physician if irritation persists
Skin Contact: Remove contaminated clothing, wash the skin thoroughly with soap and water; pay attention to any development of rashes or redness; consult medical assistance if allergic dermatologic responses occur
Ingestion: Rinse mouth out with water, drink small quantities of water if conscious; do not induce vomiting; monitor for allergic or gastrointestinal symptoms; seek medical advice depending on discomfort severity
Symptoms and Effects: Sensitization through skin or inhalation, coughing, eye watering, redness, possible swelling where contact occurred
Notes to Physician: Treat symptomatically, monitor for allergic or respiratory effects; supportive care tailored to observable symptoms
Suitable Extinguishing Media: Use water spray, CO₂, dry chemical powder, or foam, according to environmental context and availability
Special Hazards: Product itself does not burn easily; dust in air may form combustible mixtures; thermal decomposition can release carbon oxides and minor nitrogen oxides
Protective Equipment for Firefighters: Wear full protective gear and positive pressure self-contained breathing apparatus; prevent inhalation of combustion byproducts
Firefighting Procedures: Evacuate nonessential personnel, avoid stirring up dust during response, isolate runoff to prevent environmental contamination
Personal Precautions: Use respiratory protection and gloves; avoid generating and inhaling dust; ensure adequate ventilation in affected area
Environmental Precautions: Prevent entry into drains, sewers, and surface water; contain spill to smallest area possible
Cleanup Methods: Use damp methods or vacuum with high-efficiency filters for dry material; wash spill area thoroughly after removal; dispose of cleanup materials according to local regulations
Other Considerations: Isolate area, restrict unnecessary access, report large releases to responsible authorities if required by regulation
Handling: Minimize dust formation through handling practices, close containers immediately after use; use local exhaust ventilation in dust-prone settings; avoid direct contact with eyes, skin, or clothing
Storage: Store in tightly closed, labeled containers; keep at recommended temperatures, usually refrigeration between 2–8°C for optimal shelf life; protect from excessive heat, sunlight, and moisture
Packaging: Maintain containers in upright, sealed position; label clearly with hazard and identification information
Incompatible Materials: Strong oxidizing agents, strong acids and bases; avoid uncontrolled blending with other enzyme powders or chemicals
Engineering Controls: Maintain proper enclosure and local exhaust ventilation in work area; use HEPA filtration where aerosol or dust can form
Personal Protection: Wear safety glasses with side shields or goggles, chemical-resistant gloves such as nitrile, lab coats or coveralls, and particulate-filtering respirators (e.g. N95, FFP2) if airborne enzyme dust is likely
Hygiene Measures: Wash hands and face before eating or drinking; change out of and wash contaminated clothing after job completion; do not eat, drink, or smoke in processing areas
Exposure Limits: No OSHA PEL or ACGIH TLV established for amyloglucosidase; control exposure as low as reasonably achievable; some manufacturers recommend internal guideline levels in the range of <60 ng/m³ for occupational enzyme dust exposure
Appearance: Light beige to brown powder or aqueous liquid, depending on supplied form
Odor: Faint, fermentative odor in higher concentrations
pH: Typically 4.0–6.0 in aqueous solutions
Boiling Point: Not applicable for solid enzyme; >100°C for aqueous solutions
Melting Point: Not measurable (thermolabile protein denatures before melting)
Solubility: Soluble in water, forms colloidal solution; insoluble in organic solvents
Density: 1.1 to 1.3 g/cm³ for powder, varies for liquids
Other Data: Enzyme activity rapidly falls off above 60°C; stable at recommended cold storage conditions below 8°C
Chemical Stability: Stable under recommended storage and handling conditions; activity decreases gradually with time, temperature, and exposure to shear
Reactivity: May react with strong acids and bases leading to denaturation; reacts with oxidizing agents, losing activity
Hazardous Decomposition Products: Burning or decomposition produces carbon oxides, nitrogen oxides, and minor organic byproducts
Conditions to Avoid: High temperature, freezing-thawing cycles, prolonged exposure to moisture, direct sunlight
Incompatible Materials: Strong oxidants, acid chlorides, peroxides
Acute Toxicity: Oral and dermal toxicity is low; not considered acutely toxic by ingestion in mammals in routine industrial concentrations
Skin and Eye Irritation: Prolonged or repeated exposure can cause irritant and allergic reactions; dust may irritate eyes or sensitive skin
Respiratory Sensitization: Repeated inhalation of dust or aerosols can trigger asthma-like symptoms in sensitized workers; occupational asthma recognized in enzyme exposure
Other Chronic Effects: No evidence of carcinogenicity, mutagenicity, or reproductive toxicity in available studies;
Medical Conditions Aggravated by Exposure: Individuals with existing allergies, respiratory diseases, or skin sensitivity
Ecotoxicity: Not classified as harmful to aquatic organisms at typical concentrations; large releases may impact local microorganism populations due to proteinaceous nature
Persistence and Degradability: Biodegrades rapidly due to proteinaceous composition; does not bioaccumulate
Mobility: Loosely bound in soil, readily soluble in water; unlikely to persist or migrate far in the environment
Bioaccumulation Potential: No accumulation observed or expected in aquatic or terrestrial species
Other Adverse Effects: No significant ozone depletion, photochemical ozone creation, or endocrine disruption concern reported
General Disposal: Dispose of enzyme powder or solution through landfill, incineration, or treatment at industrial wastewater plants in line with local environmental regulations
Packaging Disposal: Rinse thoroughly before recycling or disposal; treat containers as chemical waste if not cleaned
Precautions: Personnel handling waste must wear recommended protective equipment to avoid exposure
Hazardous Waste Classification: Not classified as hazardous waste under most jurisdictions; confirm with local regulatory authorities
Methods Recommended: Neutralization through high temperature or industrial composting in case of large volumes
UN Number: Not regulated as dangerous goods by ADR/RID, IMDG, or IATA
Proper Shipping Name: Non-hazardous biological enzyme preparation
Transport Hazard Class: None assigned
Packing Group: No packing group defined
Special Precautions: Avoid damage and wetting of packaging during transport; ship with coolant if temperature-controlled shipping recommended
Environment Hazards: Not considered a marine pollutant
International Inventories: Listed on several country chemical inventories under enzyme or food additive categories
OSHA Status: No specific requirements under US OSHA Hazard Communication Standard but some enzyme dusts flagged as respiratory sensitizers
EU Regulations: Under REACH, identified as low risk, may fall under food or feed additive rules; classified as respiratory sensitizer per CLP
TSCA: Technical enzyme blends listed for industrial uses
Other Regulation: Occupational exposure guidelines available in some industries; user must review specific country or state requirements
Labeling: Label with pictograms, hazard, precautionary, and identification statements in line with region of use
