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Amberlyst A-21: Reshaping Practical Chemistry since the Mid-20th Century

Historical Development

Amberlyst A-21 didn’t come about overnight. The story began in the 1940s, when scientists searching for cleaner water and less cumbersome chemical processes started tinkering with crosslinked polymers. They were after something reliable to help industries churn out chemicals with fewer headaches. Early polystyrene-based resins set the tone, but most either broke down directly or brought along unwanted byproducts, throwing operations off balance. Mid-century saw a real push for “functionalized” polymers, and companies like Rohm and Haas dug into the challenge. They pushed beyond what mixing resins in a lab flask could do — they targeted controlled reactions, hoping for selective and reusable tools, and that is how Amberlyst A-21 finally found its niche. The development unlocked routes for everything from de-acidifying reaction mixtures to preparing drugs and food ingredients safely. Chemistry labs and industrial plants picked up on it because their own problem-solving required less aggressive chemicals and easier cleanup. This lineage of resin technology has anchored large swaths of chemical manufacturing ever since.

Product Overview

Amberlyst A-21 isn’t just another laboratory bottle gathering dust on a shelf. This resin is a workhorse packed with amine groups. The macroreticular, bead-like material shows up as small spheres, which pour and settle like sand but pack major chemical punch. At its core, it’s polystyrene crosslinked with divinylbenzene, grafted with tertiary amine units. Scientists and engineers like it because it’s hefty enough to withstand cycling between acid and base, lasting through repeated washing and regeneration. Handling is straightforward — one can scoop, wash, stir, and filter it, and the beads hold their shape even as solutions churn by. That simplicity lends itself well to scale-up, which is why you see Amberlyst A-21 in everything from benchtop glassware to steel-packed columns. This isn’t just a “media” — it’s often the backbone of a whole process, frequently used precisely because it won’t contribute unwanted ions to a reaction mixture.

Physical & Chemical Properties

The first thing you notice about Amberlyst A-21 is its tan to yellow hue and the way its hard beads feel — not brittle, but tough. A significant amount of crosslinking grants durability, so the resin fends off solvents that tear lesser plastics apart. It’s got a decent level of porosity, letting ions and small molecules swing in and out, bumping into the amine groups anchored in its polymer matrix. Those tertiary amines are what grab onto acids, swapping out chloride ions for organic and inorganic acids alike, though they don’t grab so tightly that the resin can’t let go when it’s time for regeneration. Over my own years in the lab, I’ve watched people tip beakers full of wildly colored solutions through beds of Amberlyst A-21, only to see them come out looking clean, with unwanted acid stripped out, and the resin beads left largely unchanged. It shrugs off both strong bases and most organic solvents, lasting through dozens of cycles before fatigue or fouling sets in. All those interconnected pores do their job, but they can clog if fed with the wrong soup of reagents, so keeping the resin clean matters for longevity.

Technical Specifications & Labeling

The real measure of Amberlyst A-21 comes from details like total exchange capacity, moisture content, size distribution, and stability limits. Typical batch certificates from reputable sellers peg its exchange capacity in the 1.0–1.4 milliequivalent/gram range — high enough to tackle most medium-scale separations or acid scavenging in a batch. Moisture usually clocks in below 60 percent, which keeps the beads manageable and ready for dry loading. Operating temperatures cap out near 60–70°C for most work; push it higher, and you risk irreversible changes to the backbone or functional group breakdown. Packaging is straightforward but not overengineered, thanks to the beads’ hardiness. Regulatory labels stick to the essentials: warnings about dust, and instructions to keep the resin away from direct acids that can degrade it over repeated cycles. In practice, clear labeling of exchange capacity and physical form keeps users safer and more efficient, ensuring no one mistakes one functionalized resin for another — a real risk when shelves are packed with dozens of similar-looking jars.

Preparation Method

Making Amberlyst A-21 takes more than blending chemicals together. The process relies on polymerizing styrene with divinylbenzene to create a rigid, porous bead, then chloromethylating the finished polymer before introducing a tertiary amine group via amination. This multistep sequence ensures the beads carry active groups distributed throughout their internal structure, helping maximize contact with target acids. Control here matters: too heavy-handed with chloromethylating, and the resin turns brittle; too little, and you leave exchange sites underused. Over the years, manufacturing teams have dialed in conditions to hit the chemical sweet spot, giving end-users confidence about resin consistency from batch to batch. That reliability is why commercial operations order drum after drum: every bead works as advertised, sparking trust between those who make the resin and those running it in multimillion-dollar assemblies.

Chemical Reactions & Modifications

Amberlyst A-21 does more than spot-absorb acids; its rich amine chemistry makes it a flexible base or scavenger in synthesis. These amines readily neutralize strong acids and can also serve as supports to anchor catalysts, allowing for clever processing steps that previously meant messy filtrations or extensive solvent washes. Chemists sometimes tinker with the resin, swelling it in solvent, tweaking its form via blending with other supports, or even introducing secondary functional groups to sharpen selectivity. For instance, labs working on complex drugs use Amberlyst A-21 to mop up residual acids left after a step, skip tedious distillations, and protect precious products from breakdown. The resin also fits nicely in solid-phase chemistry, where its amines can trigger specific reactions, letting the whole support be filtered away from a finished product. It withstands a tour through organic and aqueous media equally well, seldom breaking fractions of its own backbone into solutions, which keeps contamination risk low. Over time, beads may foul from stuck reactants or byproducts, but they can be cleaned by caustic washes and reused, a practice which both cuts costs and reduces waste — an industrial must.

Synonyms & Product Names

While Amberlyst A-21 stands out, similar resins travel under other titles. Some call it a strongly basic anion-exchange resin, or refer to specific materials by manufacturer code — but in practice, most chemical supply houses stick to the Amberlyst family name followed by a number or code. Scientists sometimes swap between A-21 and rivals with similar chemistry if supply chains shift or prices pinch, but the underlying polymer and amine backbone rarely vary much in their practical role. It's always smart to check what’s in the bottle: synonyms abound in the chemical trade, but matching capacity and compatibility with a given process will always matter more to those who rely on it for safe, repeatable outcomes.

Safety & Operational Standards

Catching a lungful of resin dust makes for an unpleasant, sometimes harmful experience, and loading up a column with the dry beads can irritate skin or eyes if you’re careless. Good lab and plant protocol helps: workers wear gloves and goggles and keep resin handling within well-ventilated or enclosed setups. Proper training still beats any safety poster, since careless transfer between columns, or tossing used resin without neutralization, risks running afoul of occupational standards. Over the years, industrial users have learned to track resin condition, swap out exhausted beds, and treat spent material as potentially hazardous waste, all while meeting environmental norms. This care keeps both people and the wider workplace healthy and compliant, reinforcing the resin’s reputation as a tool, not a risk.

Application Area

Amberlyst A-21 covers a broad landscape of use. Pharmaceutical production leans on it for acid scavenging and cleanup, helping chemists avoid the kind of product contamination that derails patient safety. Water treatment plants run it to grab unwanted organics and control pH, while food processors use it to polish up flavors or purify sweeteners. Some research teams load up packed columns or use it in stirred tanks, letting reactions run cleanly to completion with quick filtering for easy product isolation. Anyone who's ever spent an afternoon unclogging glassware with old-fashioned filtration methods will know the relief that comes from watching clean product pour through a resin-prepared system. The steady drive toward “greener” manufacturing and fewer waste streams keeps extending its reach; for many, it marks the difference between a cumbersome, hazardous process and one you’d actually want to stake your career on.

Research & Development

Ongoing curiosity and need drive fresh uses for Amberlyst A-21. Over the last decade, environmental chemists have tested its ability to mop up novel contaminants, including pesticide residues and out-of-the-ordinary organic acids that aren’t handled well by old-style ion-exchangers. Academic research pushes into making the resin work with newer, more complex target molecules, tweaking functionality to ensure selectivity — and, critically, recyclability. Advances in polymer science might introduce even more robust bead architectures, blending in finer control of pore structure and group loading, not just for show, but to help industries reduce their water, solvent, and energy use. You’ll also find collaborations between industrial chemists and resin manufacturers, all hoping to fine-tune products for tough applications like continuous-flow synthesis or high-throughput cleanups in emerging drug development pipelines.

Toxicity Research

In my own workplace and across the chemical community, attention has zeroed in on potential long-term health risks — both to people and the environment — tied to synthetic polymers. Studies suggest that while Amberlyst A-21 is not a major source of toxicity itself, improperly disposed resins can cause local trouble if not contained. Leaching of trace components or accidental burning could release hazardous substances, prompting more rigorous disposal standards and lifecycle assessments. Teams with the right analytical chops have run eluates through mass spectrometers, finding little evidence for significant leaching of hazardous monomers when the resin sees normal working conditions. Yet, regulatory bodies continue to call for careful scrutiny and environmental risk assessment, wary of microplastic-type scenarios that have plagued so many other synthetic materials. Most labs and process plants work within these guardrails, using tough protocols for resin unloading and regeneration, protecting both workers and the locations where treated water and spent solutions end up.

Future Prospects

The pressure on chemicals manufacturing to clean up its act intensifies year after year, and Amberlyst A-21 sits at the intersection of performance and responsible design. Future improvements, as seen through recent conference circuit reports and patent applications, point to resins that shrug off fouling for even longer cycles, and deliver pinpoint selectivity for emerging contaminants. Laboratories look to materials like Amberlyst A-21 as platforms for modular chemistry, tailoring the resin surface to handle entirely new classes of acids or support enzymatic and catalytic reactions never dreamed of sixty years ago. Production plants want more process reliability and easier reuse, especially as regulations tighten on disposal and lifecycle management. Manufacturers lean into advances in polymer control, dreaming up beads with more robust crosslinking and tighter pore size distribution, not as a marketing angle, but as a real answer to persistent scale-up bottlenecks. All this suggests the utility of Amberlyst A-21 will only grow, with more fields tapping its blend of robustness, selectivity, and safety. As industries continue to push for higher quality and lower impact, the humble amine resin transforms from a simple acid scavenger to an enabler of cleaner, more sustainable chemistry.




What are the main applications of Amberlyst A-21 Ion-Exchange Resin?

A Workhorse in Chemical Processing

Amberlyst A-21 resin isn’t some obscure lab material only researchers use once a year. Chemical plants run on efficiency, and this resin really pulls its weight. One of its most important applications comes in removing acidic impurities from reaction mixtures. I once toured a pharmaceutical facility where batches of drug ingredients passed through columns packed with Amberlyst A-21. The operators explained that it snags unwanted acid by swapping ions so production can stay clean, and yields don’t drop. That simplicity saves energy and sidesteps heavy metals found in many older acid-neutralizing agents.

Big Role in Sugar and Food Purification

Food manufacturers expect high purity, especially in sweeteners. The resin’s amine groups latch onto organic acids, clearing out stuff you don’t want ending up in a serving of table sugar. Processors like to use it since it doesn’t add color or flavor of its own—just pulls out the things that cause off-tastes or cloudiness. If you look around a sugar plant, the resin often works beside other filters, quietly supporting food safety and clear taste. According to Dow, the company behind the Amberlyst brand, the food industry trusts it because it stands up to repeated washings and tough sanitation rules.

Essential in Water Treatment Systems

Every drop of water that goes into a tablet or an injectable medicine needs to meet strict guidelines. Hospitals, clinics, and pharmaceutical plants turn to ion-exchange resins, like Amberlyst A-21, for water treatment because it removes weak acids and dissolved organic compounds. In practice, this means safer products and longer-lasting pipelines. Plant engineers have told me they prefer these resins for their consistent performance over many cycles, with regular regeneration using mild chemicals instead of something hazardous.

Cleaner Reactions in Synthesis and Catalysis

Synthetic chemistry relies on a solid base to neutralize or pick up acids formed during reactions. Catalysts anchored to a support make separation easier, and this resin fits the bill. In research and in scale-up, chemists mix Amberlyst A-21 into a batch, and after it mops up excess acids, it’s filtered out—no elaborate setups needed. I remember using it for creating flavor compounds in the lab. Once our reaction wrapped up, the resin sunk to the bottom, and pulling it out took less effort than fiddling with liquid bases and endless washes. Fewer side reactions cropped up, making for a cleaner product.

Potential Solutions in Environmental Cleanup

Runoff and waste streams in industry can contain all sorts of organic acids, posing a risk to local water. Resins like Amberlyst A-21 step in by exchanging ions, so environmental groups and remediation firms put them to work in filter beds. Field case studies show they’re reliable for grabbing contaminants without breaking down quickly, even when put up against harsh industrial environments. In regions with tough environmental regulations, these resins offer a way to meet targets without introducing new pollutants.

Looking Forward

Ion-exchange resin technology, especially materials like Amberlyst A-21, stands out for its balance of performance and practicality. It supports industries that drive our economy—from fine chemicals to food to clean water. The real test isn’t theory; it’s the way operators, engineers, and researchers trust it to make products better and clean up tough messes. Solutions aren’t always glamorous, but the benefits reach our kitchens, our medicine cabinets, and the environment around us.

What is the chemical composition and structure of Amberlyst A-21?

Digging into the Resin’s Backbone

Amberlyst A-21 doesn’t look like something that would grab headlines. In the lab, it shows up as tan-colored beads, easy to handle, easy to weigh. Yet, for those of us working with synthetic chemistry, the value it brings can’t be understated.

The Real Stuff: Structure and Chemistry

A-21 belongs to the family of polystyrene-based ion exchange resins. The backbone is made up of polystyrene chains cross-linked with a bit of divinylbenzene. These polymers don’t dissolve; they form a strong, yet porous structure. That rigidity means it won’t mush up under pressure or in most solvents. The cross-linking isn’t just about toughness, either. It controls pore size, which directly impacts how reactants reach the active sites sitting inside those beads.

Instead of sulfonic or carboxylic acids common in many other resins, Amberlyst A-21 carries dimethylamino functional groups attached to the benzene rings. The technical chemistry behind the linkage: tertiary amine groups grafted onto the resin through alkyl chains. If you examine the structure, you see a polystyrene skeleton with —N(CH3)2 sprouting every so often. Those amines are what set this bead apart.

Why Structure Matters in Real Life

During my time working up organic syntheses, I’ve relied on A-21 to mop up excess acids and scavenge electrophiles. Having a solid phase scavenger like this saves headaches. You don’t need to add more water and create a two-phase mess. Instead, toss in the beads and let them do the work—then filter and move on.

Strong base resins run into trouble with hydrolysis and lose their strength over repeated use. Amberlyst A-21 holds up better thanks to the tertiary amines, which swing between being nucleophilic enough to react but not so basic they’ll disintegrate in water or alcohols. The chemical stability traces right back to the resin structure—the cross-linked matrix protects the functional groups, even after repeated exposure to acids, solvents, or mild heat.

The Story in the Data

Scientific sources note the resin contains about 5-10% divinylbenzene as the cross-linker, which balances mechanical stability and accessibility to reactive groups. The exchange capacity—usually in the range of 1.0-1.5 meq/g—plays a big role in how much acid you can actually scavenge before the resin stops working.

Polystyrene resins have a long track record in chemistry. Their durability isn’t just lab folklore. Polystyrene holds up against organic solvents: ethers, alcohols, even chlorinated compounds. The success in chromatography and batch cleanups often comes from the smart pairing of backbone and pendant group.

Risks and Responsible Use

Cross-contamination isn’t unheard of. During a scale-up for a pharmaceutical ingredient, we found that not all commercial batches of Amberlyst A-21 perform the same. Impurities or inconsistent cross-linking lead to beads breaking down or channels clogging. Manufacturers publish specifications, but I always recommend validating a new source at a small scale.

Environmental safety matters here, too. Disposing of spent resin takes extra care—a mix of organic residues and non-biodegradable polymer poses a waste management challenge. Regulations limit landfill options, so chemists often rely on approved disposal partners to handle large quantities.

Pushing Forward

Switching to greener alternatives seems distant for strong, reliable resins like Amberlyst A-21. So far, no plant-based substitute comes close for stability, ease of use, or chemical resistance. The future direction likely doesn’t abandon these resins, but pushes for innovations in recycling and recovery.

Understanding the chemical skeleton and how the amines shape its behavior leads to better choices in the lab. Fighting reaction byproducts with a resin that won’t quit—this is where good chemistry meets practical, real-world problem-solving.

What are the recommended storage and handling conditions for Amberlyst A-21?

Understanding Amberlyst A-21

Amberlyst A-21 is a polymer resin widely used as a weakly basic ion-exchange agent in chemical processing. Its unique structure, based on polyacrylic backbone bound to amino functional groups, means it finds work in deacidification and other applications involving organic solutions. From years on the lab bench and time in chemical storerooms, one thing stands out: how you store and handle this resin can either support reliable results or introduce unexpected headaches.

Keep it Dry and Cool

Moisture plays havoc with many ion-exchange resins, including Amberlyst A-21. Any exposure to water vapor encourages the resin to absorb moisture, jeopardizing its performance in non-aqueous systems and raising risks of clumping. Select a storage spot away from steam pipes, wash stations, or other areas prone to condensation. A temperature between 2°C and 40°C matches manufacturer guidelines and also lines up with my own experience—colleagues who stacked it near heat sources often faced diminished shelf life.

Storing the resin in tightly sealed containers helps keep the ambient humidity away. Best practice in our lab usually involved using original factory packaging or placing the product immediately in robust, well-labeled jars. Double-bagging inside heavy-duty polyethylene adds further protection, especially in climates prone to high humidity.

No Sunbathing for Amberlyst A-21

Direct sunlight degrades the resin’s structure over time. I’ve seen more than a few shipments gone chalky from sitting by sunlit windows. Always keep containers in shaded storage, whether they’re on shipping docks or on shelves. Even those short morning rays count—UV exposure slowly ages the resin and quietly saps performance.

Safe Handling at the Workbench

Use gloves and safety goggles during transfers. The granulated form of Amberlyst A-21 can generate dust, and its amine groups can cause mild irritation. If you ever spill resin onto a bench or floor, sweep or vacuum it up rather than wet-mop; water only makes it stickier and harder to collect. Working in a ventilated area helps, too, in case of accidental dust generation.

It matters what solvents contact the resin before use. Amberlyst A-21 holds up well in alcohols, ethers, and many organic solvents, but strong acids or oxidizing agents wreck its structure. I’ve seen melted samples from forgetting this simple precaution. So double-check compatibility before adding it to any novel reaction mixture.

Storing Used and Spent Resin

Spent resin can hold onto process residues—sometimes corrosive or toxic. Separate containers for used resin and clear labeling reduce cross-contamination. In industrial settings I’ve observed, it’s common to rinse spent resin with an appropriate solvent first, then seal it tightly for disposal according to local regulations. Never mix waste streams unless you know exactly how materials will interact.

Looking After Quality—and Yourself

By following these commonsense guidelines, you prevent most issues with Amberlyst A-21. Storing it dry, cool, and out of sunlight shields your investment and your results. Good labeling, sensible container choices, and careful bench handling—these practices keep everyone in the lab safe, and keep the resin ready for action when you need it.

How do you regenerate or clean Amberlyst A-21 after use?

The Messy Reality of Used Resin

Amberlyst A-21 doesn’t stay squeaky clean after pulling amines or free bases out of a batch. Over a busy week in the lab, I’ve pulled out beds caked with traces of organics, odd color changes, and the unmistakable signs that the beads are no longer pulling their weight. Tossing them never helps budgets, so the question everyone ends up asking: how do you get this resin back to business?

Lift Out the Junk: Step Up the Cleaning

Picture the resin as a kitchen sponge after a marathon of cooking—gummed up and in need of more than a rinse. Just flushing water through doesn’t do much. Instead, start with flushing the bed with a load of deionized water, pushing out as much leftover product as you can. Without this first step, any further effort just spreads the mess.

Next, an ethanol wash makes a real difference. From my own runs, ethanol (or methanol if that’s what’s around) clears out stubborn organics. Run enough through so the runoff looks clear. You’re not just chasing color here; you want no whiff of old product left behind.

Regeneration: The Key Step

Over time, the resin’s basic amine sites get tied up with acids or product molecules. Getting those sites free again means a solid wash with a dilute mineral acid—hydrochloric or sulfuric acid, usually in the 2 to 5% range. I’ve measured out enough beakers of 2 M HCl to know: pour it through slowly, keeping an eye on the pH. Once it drops to around 2–3, most bound product breaks loose.

Don’t let the resin stew in acid for too long, or it might start to break down. Once acidity shows up in the draining liquid, rinse out the acid with more water until the pH drifts up near neutral. The cleaned resin should feel a little slippery, a sign the surface is stripped of grime.

Back to Work

The final step isn’t glamorous but makes all the difference. Pass a dilute sodium hydroxide solution through to reactivate the functional groups. Wait until the pH tips past 10, which tells you the resin’s ready for its base-exchange duties all over again. If the resin handled a lot of color or odd smells—from my own misadventures with aromatic amines—a round with a bit of bleach or hydrogen peroxide can strip out those stubborn stains. Rinse well; you don’t want oxidizer hanging around.

Why Take the Trouble?

Many labs write off resin beds too early, burning through supplies. Regeneration cuts costs and trim waste, which matters as research shifts toward green chemistry. By learning the signs of spent versus salvageable resin, you save money and keep your methods sharp. Make a habit of tracking each cycle; if a resin batch ever slips below performance standards, consider swapping out rather than propping up the exhausted media.

Final Thoughts: Keep It Practical

Understanding the cleaning chemistry goes beyond the bottle directions. Each regeneration is a balance. Go slow, monitor the pH, use enough wash to clear the byproducts, and don’t shortcut the rinses. Proper care means resin can see dozens of cycles, not just a handful. That saves budgets and keeps workflows steady.

Drawing from experience keeps the process safe and predictable, and it keeps the hardware out of landfills longer. Not every batch needs bleach or a heavy-duty fix, but every routine needs attention to detail. That’s how you keep Amberlyst A-21 on the job.

What is the typical ion-exchange capacity of Amberlyst A-21 resin?

Why Ion-Exchange Capacity Matters in Everyday Chemistry

People in labs reach for ion-exchange resins like Amberlyst A-21 because they have jobs to do—removing unwanted ions or scavenging contaminants in water, chemicals, or pharmaceuticals. Knowing how much stuff a resin can actually swap out isn’t trivia. It’s the line between a process running smoothly and equipment fouling, or product purity missing its mark. For Amberlyst A-21, the number that comes up most often is around 1.2 meq/g of dry resin. That’s milliequivalents, and for folks outside the science field, it basically reflects how many “seats” this resin has for grabbing hold of amine-bound ions. Compare that to other weakly basic resins, and it holds its own.

Real-World Numbers from Industry

Manufacturers like DuPont and professional resellers consistently cite Amberlyst A-21’s capacity ranging from 1.2 up to about 1.3 meq/g (dry basis). I’ve seen specs at 1.15 as well, depending on production batches and the exact test setup. It’s a good idea not to push those limits unless you’re fine with frequent resin changeouts or process hiccups. For operators in pharma or specialty chemicals, this means predicting exactly how much resin is needed for a batch, without wasting time or money. I’ve worked with process engineers who keep spreadsheets, tracking run histories. That 1.2 meq/g number drives their choices about filter sizing and even how often they switch out beds. Skimping leads to clogging, resin exhaustion, and the kind of troubleshooting that nobody wants late on a Friday.

Trouble Spots and What Can Go Wrong

Ion-exchange sounds technical, but it boils down to simple math and hard realities. Any plant tech who’s dealt with amine-type resins knows about what happens if you load up too much calcium, magnesium, or even weird organics—performance tanks. Amberlyst A-21 can start strong at 1.2 meq/g, but dirty water, high temperature, or oxygen in the wrong spot slowly chews away at those active sites. If nobody checks total exchange capacity once in a while, all the nice printed specs in the binder become useless. I’ve seen systems work great for months, then slip beneath required purity just because the resin load quietly faded without anyone testing.

Potential Paths Forward

Aging plants and tighter discharge limits mean the margin for error shrinks every year. Running regular resin capacity tests with column titration beats reading spreadsheets or assuming every batch leaves the factory fresh. Operators can improve performance by avoiding overloading cycles, providing proper regeneration (using the right acid or base), and filtering out oxidants and suspended solids before water ever touches the resin bed.

Decisions about which resin to use won’t hinge just on exchange capacity—but knowing the ballpark for Amberlyst A-21 gives buyers and engineers a grounded place to start. With 1.2 meq/g as a real-world reference, nobody’s left guessing, and process reliability gets a solid shot.

Amberlyst A-21 Ion-Exchange Resin
Names
Preferred IUPAC name Poly{[(2-hydroxypropyl)dimethylammonium] methylstyrene chloride}
Other names Amberlyst A21
Amberlyst™ A21
Amberlyst A-21
Amberlyst A-21 resin
Amberlyst IRA-67
Rohm and Haas A-21
Macron A21
Pronunciation /ˈæm.bər.lɪst ˌeɪ ˈtwɛnti wʌn ˌaɪ.ɒn ɪksˈʧeɪndʒ ˈriː.zɪn/
Identifiers
CAS Number 110617-16-8
Beilstein Reference 3928221
ChEBI CHEBI:53233
ChEMBL CHEMBL2108700
ChemSpider 24681309
DrugBank DB13879
ECHA InfoCard 100.131.322
EC Number 'EC 500-120-0'
Gmelin Reference 1808733
KEGG C01435
MeSH Amberlyst A-21 Ion-Exchange Resin
PubChem CID 24869944
RTECS number OV4385000
UNII UNII: 70P6RH1MFW
UN number UN3077
CompTox Dashboard (EPA) DTXSID1020635
Properties
Chemical formula (C8H8NCH3)n
Appearance Off-white spherical beads
Odor Slightly amine-like
Density 0.93 g/mL
Solubility in water Insoluble in water
log P 0.10
Vapor pressure Vapor pressure: negligible
Acidity (pKa) Weakly basic (pKa ≈ 10)
Basicity (pKb) Basicity (pKb): 4.6
Magnetic susceptibility (χ) -9.04 × 10⁻⁶ cm³/mol
Refractive index (nD) 1.05
Dipole moment Dipole moment: 0.00 D
Thermochemistry
Std molar entropy (S⦵298) 179 J/mol·K
Hazards
Main hazards May cause an allergic skin reaction.
GHS labelling GHS07, Warning, H317, P261, P272, P280, P302+P352, P333+P313, P363, P501
Pictograms GHS07, GHS09
Signal word Warning
Hazard statements H317: May cause an allergic skin reaction.
NFPA 704 (fire diamond) 1-1-0
Flash point Flash point: >100°C (>212°F)
LD50 (median dose) > 10 g/kg (rat, oral)
NIOSH NA848
PEL (Permissible) PEL (Permissible) : Not established.
REL (Recommended) 1 – 2 mL resin per g substrate
IDLH (Immediate danger) Not established
Related compounds
Related compounds Amberlyst 15
Amberlite IRA-400
Amberlyst A-26
DOWEX 1X8
Amberlite IRA-67