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Product Name: Acrylamide
Chemical Formula: C3H5NO
Molecular Weight: 71.08 g/mol
Synonyms: 2-Propenamide, Acrylic amide
CAS Number: 79-06-1
Recommended Use: Polymer manufacture, laboratory reagent, electrophoresis
Manufacturer/Supplier Information: Manufacturer’s full name, emergency contact phone number, address, and local supplier details as applicable
Emergency Phone Number: Should be included based on local regulations and company policy for immediate consultation
Classification: Toxic if swallowed, by inhalation, or through skin; potential neurotoxin; suspected carcinogen; harmful to aquatic life
Label Elements: Skull and crossbones pictogram; hazard statements related to acute toxicity and chronic health effects; precautionary statements focusing on exposure minimization and prompt medical attention
Routes of Exposure: Inhalation, skin contact, ingestion, and eye contact
Main Hazards: Central and peripheral nervous system damage, irritation of eyes, skin, and respiratory tract, risk of cancer upon repeated or prolonged exposure, possible genetic defects
Symptoms: Staggering, muscle weakness, drowsiness, skin numbness (especially in fingers and toes), excessive sweating, slurred speech, tremor, headaches, and nausea
Target Organs: Nervous system, skin, eyes
Chemical Name: Acrylamide
Concentration: 98% or greater (for laboratory grade); lower concentrations for aqueous solutions depending on intended use
Other Components: Water or buffer solutions as diluents for some preparations; stabilizers to prevent unwanted polymerization
Impurities: Trace monomers and polymerization inhibitors commonly found in commercial acrylamide products
Threshold Limit Values: Reference to any known exposure limit set by OSHA, ACGIH, NIOSH, or other regulatory bodies
Inhalation: Move person to fresh air; keep at rest; seek medical attention for symptoms such as shortness of breath, drowsiness, or loss of coordination; provide artificial respiration if breathing has stopped
Skin Contact: Remove contaminated clothing; wash skin gently and thoroughly with soap and water for at least 15 minutes; do not delay medical attention if numbness, irritation, or burns develop
Eye Contact: Immediately flush eyes with water or saline for at least 15 minutes, holding eyelids open to ensure thorough rinsing; seek immediate ophthalmological evaluation
Ingestion: Do not induce vomiting; give water if victim is conscious; immediate medical intervention is important; never provide liquids to an unconscious person
Additional Notes: Monitor for neurological symptoms up to several hours or days after significant exposure; ensure proper PPE for anyone giving first aid
Suitable Extinguishing Media: Water spray, carbon dioxide, dry powder, foam depending on circumstances
Hazardous Combustion Products: Nitrogen oxides, carbon oxides, ammonia, potentially toxic acrylamide fumes
Specific Hazards: Dust or vapors may form explosive mixtures with air; acrylamide decomposes at high temperatures; containers may rupture under fire conditions
Protective Equipment: Self-contained breathing apparatus and full protective fire-resistant clothing; avoid inhaling gases from fire
Fire-Fight Procedures: Approach from upwind, contain contaminated runoff, isolate affected area; avoid water contamination
Personal Precautions: Evacuate non-essential personnel; wear gloves, protective clothing, and approved respirator
Environmental Precautions: Prevent entry into drains, soil, or water sources; acrylamide poses risks to aquatic environments
Spill Cleanup: Ventilate area; use HEPA-filtered vacuum or scoop up solids with non-sparking tools; minimize dust generation; collect in sealed, labeled containers for disposal under hazardous waste regulations; decontaminate spill area with dilute sodium hypochlorite
Disposal of Collected Material: Same procedures as for hazardous chemical waste apply
Notification Requirements: Report significant spills to local authorities as required by regulatory frameworks
Handling: Use only in chemically resistant, well-ventilated spaces; avoid all personal contact with powder and solutions; avoid inhalation of dust or vapors; keep away from sources of heat and ignition; do not eat, drink, or smoke while handling; wash hands thoroughly after use
Storage: Store in cool, dry, well-ventilated area in tightly closed containers; segregate from oxidizers, strong acids, bases, and reducing agents; project from direct sunlight, heat, and sources of mechanical shock
Special Precautions: Use only corrosion-proof containers with secondary containment; implement measures for spill detection and emergency response
Occupational Exposure Limits: OSHA PEL: 0.03 mg/m³ TWA (skin notation); ACGIH TLV: 0.03 mg/m³ TWA (skin)
Engineering Controls: Local exhaust ventilation, fume hoods, closed systems for transfer and handling processes
Personal Protection: Nitrile gloves, lab coat, chemical-resistant face shield, and splash goggles; full-face respirator with P100 filter for dusty or vapor-generating operations; impermeable apron and footwear for large quantity handling
Hygiene Measures: Wash hands, arms, and face before eating, drinking, smoking, or using restrooms; regularly inspect and clean protective equipment
Monitoring: On-site air sampling, biological monitoring for occupational health surveillance, regular workplace hazard assessments
Appearance: White, odorless crystalline solid
Odor Threshold: Very low; often undetectable at hazardous concentrations
pH (aqueous solutions): Neutral to slightly acidic depending on concentration
Melting Point: 84-85 °C
Boiling Point: 125 °C (decomposes)
Flash Point: 138 °C (closed cup)
Auto-ignition Temperature: Not easily ignited in powder form; decomposition temperature around 160°C
Solubility in Water: Highly soluble
Vapor Pressure: <0.01 mmHg at 20°C
Relative Density: 1.122 g/cm³ (20°C)
Partition Coefficient (n-octanol/water): -0.67
Evaporation Rate: Not significant under ambient conditions
Viscosity: Not relevant for solid
Chemical Stability: Stable under recommended storage and handling; sensitive to light and warmth which may increase polymerization rate
Conditions to Avoid: Heat, light, ignition sources, strong acids, bases, and oxidizing or reducing agents
Polymerization: Hazardous polymerization may occur upon heating or in the presence of initiators or contaminants
Incompatible Materials: Oxidizers, strong acids, copper, iron; spontaneous polymerization may result
Decomposition Products: Ammonia, nitrogen oxides, carbon monoxide, and toxic acrylamide fumes
Acute Toxicity: Oral LD50 (rat): ~124 mg/kg; skin LD50 (rabbit): ~400 mg/kg; inhalation LC50 (rat): ~400 mg/m³ (4 hr)
Chronic Effects: Neurotoxicity characterized by ataxia, muscle weakness, and neurological deficits after repeated exposure; carcinogenicity suspected by IARC (Group 2A, probable human carcinogen); evidence for reproductive and developmental toxicity in animals
Irritant Properties: Causes eye, skin, and respiratory tract irritation
Other Health Effects: Mutagenic effects observed in cell culture and animal testing; evidence for DNA damage and effects on reproduction in exposed animals
Medical Conditions Aggravated by Exposure: Pre-existing neurological, respiratory, or skin disorders
Ecotoxicity: Highly toxic to aquatic life, even at low concentrations; LC50 fish (96 hr): 130 mg/L (bluegill); Daphnia magna EC50 (48 hr): 98 mg/L
Persistence and Degradability: Degrades in the environment but with potential persistence in water and soils under some circumstances; breakdown products can retain toxicity
Bioaccumulation Potential: Low potential due to high water solubility but risk of exposure in aquatic food chains
Mobility in Soil: High; fast movement through soil can lead to groundwater contamination risk
Other Adverse Effects: Inhibition of biodegradation in wastewater treatment; chronic exposure can disrupt aquatic food chains
Waste Disposal Methods: Dispose in accordance with federal, state, and local hazardous waste regulations; do not release into sewers or public waterways; incinerate under controlled conditions or send to licensed hazardous waste facility
Contaminated Packaging: Decontaminate before reuse or disposal; puncture prevention and triple rinsing recommended; full labeling as hazardous waste
Special Precautions: Record-keeping of disposal batches, regular staff training, and contingency plans for accidental releases during handling or transport
UN Number: UN 2074
Proper Shipping Name: Acrylamide, solid
Transport Hazard Class: 6.1 (toxic substance)
Packing Group: III
Environmental Hazards: Considered hazardous to the aquatic environment; label with marine pollutant symbol where required
Special Precautions for Transport: Protect from heat, keep containers tightly sealed; secure to prevent overturn or spillage; emergency response instructions provided for all shipments
Regulatory Requirements: Comply with DOT, IATA, IMDG code as applicable to mode of transport and destination
Regulatory Status: Subject to control under OSHA Hazard Communication Standard, Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), Toxic Substances Control Act (TSCA), European REACH, Canadian WHMIS, and other country-specific regulations
Labeling Requirements: GHS-compliant labels required, including hazard pictograms, signal words, hazard and precautionary statements, and supplier details
Exposure Limits: OSHA, ACGIH, and NIOSH have established occupational exposure limits enforced by workplace health authorities
Inventory Status: Registered or listed on chemical inventories in United States, EU, Japan, Canada, Australia, Korea, and others
Community Right-to-Know: Mandatory public disclosure for certain quantities held under U.S. SARA Title III
Other Regulations: Restrictions on use in consumer products and food packaging; stricter rules for wastewater discharge and emissions to air
